Results 101 to 110 of about 6,830 (257)

Identification of Genes Potentially Regulated by Human Polynucleotide Phosphorylase (hPNPaseold-35) Using Melanoma as a Model [PDF]

, 2013
Human Polynucleotide Phosphorylase (hPNPaseold-35 or PNPT1) is an evolutionarily conserved 3′→5′ exoribonuclease implicated in the regulation of numerous physiological processes including maintenance of mitochondrial homeostasis, mtRNA import and aging ...
Bacolod, Manny D., Das, Swadesh K., Dasgupta, Santanu, Emdad, Luni, Sokhi, Upneet K.   +4 more
core   +2 more sources

Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation

WIREs RNA, Volume 16, Issue 2, March/April 2025.
GEMIN5 structural domains. Overview of GEMIN5's role in snRNP assembly and translation regulatory events. ABSTRACT GEMIN5 is a predominantly cytoplasmic protein, initially identified as a member of the survival of motor neurons (SMN) complex. In addition, this abundant protein modulates diverse aspects of RNA‐dependent processes, executing its ...
Encarnacion Martinez‐Salas, Salvador Abellan, Rosario Francisco‐Velilla   +2 more
wiley   +1 more source

Dysregulated ribosome quality control in human diseases

The FEBS Journal, Volume 292, Issue 5, Page 936-959, March 2025.
Ensuring the synthesis of full‐length, correctly folded proteins is vital for maintaining homeostasis. If a translating ribosome stalls, the trailing ribosomes collide into it, which if left unresolved leads to deleterious effects on the cell due to the accumulation of protein aggregates.
Tom McGirr, Okan Onar, Seyed Mehdi Jafarnejad   +2 more
wiley   +1 more source

RNA Processing [PDF]

, 2019
International audienceRNAs can be either transcribed directly as functional species or as molecules that require post-transcriptional processing by ribonucleases.
Baumgardt, Bechhofer, Braun, Condon, Condon, Dunn, Even, Gilet, Li, Li, Mathy, Pellegrini, Redko, Sirdeshmukh, Yao   +14 more
core   +1 more source

Developing a peripheral blood RNA‐seq based NETseq ensemble classifier: A potential novel tool for non‐invasive detection and treatment response assessment in neuroendocrine tumor patients receiving 177Lu‐DOTATATE PRRT

Journal of Neuroendocrinology, Volume 37, Issue 3, March 2025.
Abstract Neuroendocrine tumors (NETs) are presented with metastases due to delayed diagnosis. We aimed to identify NET‐related biomarkers from peripheral blood. The development and validation of a multi‐gene NETseq ensemble classifier using peripheral blood RNA‐Seq is reported. RNA‐Seq was performed on peripheral blood samples from 178 NET patients and
Mahesh K. Padwal, Rahul V. Parghane, Avik Chakraborty, Aman Kumar Ujaoney, Narasimha Anaganti, Sandip Basu, Bhakti Basu   +6 more
wiley   +1 more source

Arenaviridae exoribonuclease presents genomic RNA edition capacity [PDF]

, 2019
AbstractThe Arenaviridae is a large family of viruses causing both acute and persistent infections and causing significant public health concerns in afflicted regions. A “trademark” of infection is the quick and efficient immuno-suppression mediated in part by a 3’-5’ RNA exonuclease domain (ExoN) of the Nucleoprotein (NP).
E.L. Yekwa, E.L. Yekwa, E.L. Yekwa, Caroline Picard, Xavier Carnec, Sylvain Baize, François Ferron, François Ferron, Bruno Canard, Bruno Canard, Aphibanthammakit C, Aphibanthammakit C, Bruno Coutard, Bruno Coutard   +13 more
openaire   +3 more sources

Stress resilience in plants: the complex interplay between heat stress memory and resetting

New Phytologist, Volume 245, Issue 6, Page 2402-2421, March 2025.
Summary Heat stress (HS) poses a major challenge to plants and agriculture, especially during climate change‐induced heatwaves. Plants have evolved mechanisms to combat HS and remember past stress. This memory involves lasting changes in specific stress responses, enabling plants to better anticipate and react to future heat events.
Tobias Staacke, Bernd Mueller‐Roeber, Salma Balazadeh   +2 more
wiley   +1 more source

Polynucleotide phosphorylase has an impact on cell biology of Campylobacter jejuni [PDF]

, 2012
Polynucleotide phosphorylase (PNPase), encoded by the pnp gene, is known to degrade mRNA, mediating post-transcriptional regulation and may affect cellular functions. The role of PNPase is pleiotropic. As orthologs of the two major ribonucleases (RNase E
Christopher M. Burns, Didier Chevret, Hervé Prévost, Jean M. Cappelier, Katell Rivoal, Nabila Haddad, Odile Tresse, Quentin Nonglaton   +7 more
core   +1 more source

Unleashing viral mimicry: A combinatorial strategy to enhance the efficacy of PARP7 inhibitors

BioEssays, Volume 47, Issue 2, February 2025.
This review explores the potential of inducing a viral mimicry‐primed state by combining PARP7 inhibitors with drugs that promote the accumulation of self‐nucleic acids. This synergistic approach could enhance apoptosis and the immune response against cancer cells with elevated IFN‐stimulated gene (ISG) scores, providing a promising avenue for ...
Patrick Manetsch, Michael O. Hottiger
wiley   +1 more source

Purification of a human polyribosome-associated 3‘ to 5‘ exoribonuclease. [PDF]

Journal of Biological Chemistry, 1994
In cells and cell-free extracts, the early steps in histone mRNA decay occur at the 3' terminus and appear to be catalyzed by a polysome-associated 3' to 5' exoribonuclease. We describe the purification of a polysomal 3' to 5' exoribonuclease that is magnesium-dependent, active at pH 7-8 in salt concentrations below 200 mM, and resistant to the ...
N Caruccio, Jeffrey Ross
openaire   +2 more sources