Results 61 to 70 of about 3,047 (148)

ISG20L2, a Novel Vertebrate Nucleolar Exoribonuclease Involved in Ribosome Biogenesis [PDF]

Molecular & Cellular Proteomics, 2008
Proteomics analyses of human nucleoli provided molecular bases for an understanding of the multiple functions fulfilled by these nuclear domains. However, the biological roles of about 100 of the identified proteins are unpredictable. The present study describes the functional characterization of one of these proteins, ISG20L2.
Couté, Yohann, Kindbeiter, Karine, Belin, Stéphane, Dieckmann, Régis, Duret, L., Bezin, Laurent, Sanchez, Jean-Charles, Diaz, Jean-Jacques   +7 more
openaire   +4 more sources

Five‐Year (2017–2022) Evolutionary Dynamics of Human Coronavirus OC43 in Southern France Based on Whole Genome Next‐Generation Sequencing

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT HCoV‐OC43 genomes and their evolution are scarcely studied worldwide and in France, with only 361 genomes available as of October 2023. Here, an in‐house PCR amplification system was implemented to obtain retrospectively by next‐generation sequencing, then analyze HCoV‐OC43 genomes for infections diagnosed with this virus in southern France ...
Hikmat Houmadi, Céline Boschi, Marine Lefebvre, Lorlane Le Targa, Justine Py, Jean‐Christophe Lagier, Lucile Lesage, Jacques Fantini, Aurélie Morand, Bernard La Scola, Philippe Colson   +10 more
wiley   +1 more source

Substrate Recognition and Catalysis by the Exoribonuclease RNase R [PDF]

Journal of Biological Chemistry, 2006
RNase R is a processive, 3' to 5' hydrolytic exoribonuclease that together with polynucleotide phosphorylase plays an important role in the degradation of structured RNAs. However, RNase R differs from other exoribonucleases in that it can by itself degrade RNAs with extensive secondary structure provided that a single-stranded 3' overhang is present ...
Helen A, Vincent, Murray P, Deutscher
openaire   +2 more sources

Molecular Characterization of the Group A Streptococcus Virulence‐Regulatory System FasBCAX

Molecular Microbiology, Volume 124, Issue 6, Page 521-537, December 2025.
The Fas system of the group A Streptococcus is comprised of three proteins (FasBCA) and a small regulatory RNA (FasX), and it represses adhesin production while also promoting the production of the spreading factor streptokinase. Here, we analyze the Fas proteins to assess how they positively regulate FasX production.
Sushila Baral, Roshika Roshika, Clay P. Renshaw, Ameya Singh, Ashna Prabhu, Ira Jain, Rebekah Woolsey, David Quilici, Yftah Tal‐Gan, Paul Sumby   +9 more
wiley   +1 more source

Photocaged Dinucleoside Tetraphosphates for Light‐Mediated Activation of 5′ Cap Interactions and Translation In Vitro

ChemistryEurope, Volume 3, Issue 6, November 11, 2025.
Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling, Wiebke Teich, Bayram Terzi, Helena Schepers, Sabine Hüwel, Andrea Rentmeister   +5 more
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, Volume 15, Issue 11, Page 1874-1885, November 2025.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Exoribonuclease in nonstructural protein 14 (nsp14-ExoN) [PDF]

Science-Business eXchange, 2013
In vitro studies suggest nsp14-ExoN inhibitors could help sensitize coronaviruses to RNA mutagen therapeutics including ribavirin.
openaire   +1 more source

Structural and functional studies of the decapping exoribonucleases [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
Recent studies showed that two homologous yeast proteins, Rai1 and Dxo1, function in a quality control mechanism to clear cells of incompletely 5' end-capped messenger RNAs (mRNAs). Rai1 possesses a novel decapping activity that can remove the entire cap structure dinucleotide from an mRNA.
Jeong Ho Chang, Liang Tong
openaire   +1 more source

Mixed Messages: Dynamic and Compositional Heterogeneity of Nuclear Messenger Ribonucleoprotein (mRNP) Complexes

WIREs RNA, Volume 16, Issue 6, November/December 2025.
RNA‐protein (RNP) complexes formed by a network of RNA–RNA, RNA–protein, and protein–protein interactions are central to gene expression. mRNP compositional heterogeneity underlies precise regulation (e.g., export, storage, translation, and decay), enabling cells to adapt to changing conditions, with changes in composition further linked to stress ...
Theresa Wechsler, Ryuta Asada, Ben Montpetit   +2 more
wiley   +1 more source

Elevated Wall Tension Leads to Reduced miR‐133a in the Thoracic Aorta by Exosome Release

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Reduced miR‐133a was previously found to be associated with thoracic aortic (TA) dilation, as seen in aneurysm disease. Because wall tension increases with vessel diameter (Law of Laplace), this study tested the hypothesis that elevated ...
Adam W. Akerman, Walker M. Blanding, Robert E. Stroud, Elizabeth K. Nadeau, Rupak Mukherjee, Jean Marie Ruddy, Michael R. Zile, John S. Ikonomidis, Jeffrey A. Jones   +8 more
doaj   +1 more source