Results 81 to 90 of about 6,830 (257)

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

PLOS Pathogens, 2020
Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal CoV replication, the mechanisms and determinants of CoV recombination are not known.
Jennifer Gribble, Laura J. Stevens, Maria L. Agostini, Jordan Anderson-Daniels, James D. Chappell, Xiaotao Lu, Andrea J. Pruijssers, Andrew L. Routh, Mark R. Denison   +8 more
openaire   +5 more sources

Solid-phase XRN1 reactions for RNA cleavage: application in single-molecule sequencing [PDF]

, 2022
Modifications in RNA are numerous (∼170) and in higher numbers compared to DNA (∼5) making the ability to sequence an RNA molecule to identify these modifications highly tenuous using next generation sequencing (NGS).
Amarasekara, Charuni A., Athapattu, Uditha S., Barany, Francis, Bloom, Steven, Immel, Jacob R., Nagel, Aaron C., Soper, Steven A.   +6 more
core   +1 more source

Multiple Exoribonucleases Catalyze Maturation of the 3′ Terminus of 16S Ribosomal RNA (rRNA)*

Journal of Biological Chemistry, 2013
Background: The RNases involved in 3′ maturation of E. coli 16S rRNA were not known. Results: E. coli mutants lacking RNase II, RNase R, PNPase, and RNase PH accumulate 17S rRNA precursor.
S. Sulthana, M. Deutscher
semanticscholar   +1 more source

Landscape of functional interactions of human processive ribonucleases revealed by high-throughput siRNA screenings

iScience, 2021
Summary: Processive exoribonucleases are executors of RNA decay. In humans, their physical but not functional interactions were thoughtfully investigated. Here we have screened cells deficient in DIS3, XRN2, EXOSC10, DIS3L, and DIS3L2 with a custom siRNA
Anna Hojka-Osinska, Aleksander Chlebowski, Joanna Grochowska, Ewelina P. Owczarek, Kamila Affek, Kamila Kłosowska-Kosicka, Roman J. Szczesny, Andrzej Dziembowski   +7 more
doaj  

Attachment of the RNA degradosome to the bacterial inner cytoplasmic membrane prevents wasteful degradation of rRNA in ribosome assembly intermediates.

PLoS Biology, 2023
RNA processing and degradation shape the transcriptome by generating stable molecules that are necessary for translation (rRNA and tRNA) and by facilitating the turnover of mRNA, which is necessary for the posttranscriptional control of gene expression ...
Lydia Hadjeras, Marie Bouvier, Isabelle Canal, Leonora Poljak, Quentin Morin-Ogier, Carine Froment, Odile Burlet-Schlitz, Lina Hamouche, Laurence Girbal, Muriel Cocaign-Bousquet, Agamemnon J Carpousis   +10 more
doaj   +1 more source

SAL1‐PAP retrograde signaling orchestrates photosynthetic and extracellular reactive oxygen species for stress responses

The Plant Journal, Volume 122, Issue 5, June 2025.
SUMMARY Cellular responses to abiotic stress involve multiple signals such as reactive oxygen species (ROS), Ca2+, abscisic acid (ABA), and chloroplast‐to‐nucleus retrograde signals such as 3′‐phosphoadenosine 5′‐phosphate (PAP). The mechanism(s) by which these messengers intersect for cell regulation remain enigmatic, as do the roles of retrograde ...
Estee E. Tee, Stephen J. Fairweather, Hanh M. Vo, Chenchen Zhao, Andrew Breakspear, Sachie Kimura, Melanie Carmody, Michael Wrzaczek, Stefan Bröer, Christine Faulkner, Jaakko Kangasjärvi, Zhong‐Hua Chen, Barry J. Pogson, Kai Xun Chan   +13 more
wiley   +1 more source

Landscape of RNA polyadenylation in E-coli [PDF]

, 2016
Polyadenylation is thought to be involved in the degradation and quality control of bacterial RNAs but relatively few examples have been investigated.
Aurell, Erik, Gracia, Celine, Hajnsdorf, Eliane, Innocenti, Nicolas, Maes, Alexandre, Zhang, Kaiyang   +5 more
core   +2 more sources

The roles of 3′-exoribonucleases and the exosome in trypanosome mRNA degradation

RNA: A publication of the RNA Society, 2013
This paper reports results on studies of mRNA decay in Trypanosoma brucei. Surprisingly, mRNA decay of unstable and intermediate stability mRNAs is mediated by different degradative pathways.
Abeer A. Fadda, Valentin Färber, Dorothea Droll, C. Clayton   +3 more
semanticscholar   +1 more source

In vivo 3′-to-5′ exoribonuclease targetomes of Streptococcus pyogenes [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance To cope with harsh environments and cause infection, bacteria need to constantly adjust gene expression. Ribonucleases (RNases) control the abundance of regulatory and protein-coding RNA through degradation and maturation.
Anaïs Le Rhun, Thibaud T. Renault, Thibaud T. Renault, Anne-Laure Lécrivain, Anne-Laure Lécrivain, Emmanuelle Charpentier, Emmanuelle Charpentier, Karin Hahnke, Rina Ahmed-Begrich   +8 more
openaire   +5 more sources

Extracellular Vesicles Alter Trophoblast Function in Pregnancies Complicated by COVID‐19

Journal of Extracellular Vesicles, Volume 14, Issue 4, April 2025.
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and resulting coronavirus disease (COVID‐19) cause placental dysfunction, which increases the risk of adverse pregnancy outcomes. While abnormal placental pathology resulting from COVID‐19 is common, direct infection of the placenta is rare.
Thea N. Golden, Sneha Mani, Rebecca L. Linn, Rita Leite, Natalie A. Trigg, Annette Wilson, Lauren Anton, Monica Mainigi, Colin C. Conine, Brett A. Kaufman, Jerome F. Strauss III, Samuel Parry, Rebecca A. Simmons   +12 more
wiley   +1 more source