Results 1 to 10 of about 83,398 (334)

Validation of a CE-IVD, urine exosomal RNA expression assay for risk assessment of prostate cancer prior to biopsy

Scientific Reports, 2022
Improved risk stratification of patients suspected of prostate cancer prior to biopsy continues to be an unmet clinical need. ExoDx Prostate (IntelliScore) “EPI” is a non-invasive urine test utilizing RNA from exosomes to provide a risk score that ...
Alexander Kretschmer, Holger Kajau, Eric Margolis, Ronald Tutrone, Tobias Grimm, Matthias Trottmann, Christian Stief, Georg Stoll, Christian A. Fischer, Claudia Flinspach, Anja Albrecht, Lisa Meyer, Tina Priewasser, Daniel Enderle, Romy Müller, Phillipp Torkler, Jason Alter, Johan Skog, Mikkel Noerholm   +18 more
doaj   +1 more source

Exosome based analysis for Space Associated Neuro-Ocular Syndrome and health risks in space exploration

npj Microgravity, 2022
Molecular profiling to characterize the effects of environmental exposures is important from the human health and performance as well as the occupational medicine perspective in space exploration.
Sudipto K. Chakrabortty, Yevgenia L. Khodor, Robert R. Kitchen, Dulaney L. Miller, Kailey M. Babcock, Kyle S. Manning, Steven P. Lang, Vasisht Tadigotla, Wei Yu, Eric Bershad, Johan Skog, Susana Zanello   +11 more
doaj   +1 more source

Atorvastatin Enhances the Efficacy of Immune Checkpoint Therapy and Suppresses the Cellular and Extracellular Vesicle PD-L1

Pharmaceutics, 2022
According to clinical studies, statins improve the efficacy of programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) blockade therapy for breast cancer; however, the underlying mechanisms are unclear.
Eun-Ji Choe, Chan-Hyeong Lee, Ju-Hyun Bae, Ju-Mi Park, Seong-Sik Park, Moon-Chang Baek   +5 more
doaj   +1 more source

Ovarian-Cancer-Associated Extracellular Vesicles: Microenvironmental Regulation and Potential Clinical Applications

Cells, 2021
Ovarian cancer (OC) is one of the most diagnosed gynecological cancers in women. Due to the lack of effective early stage screening, women are more often diagnosed at an advanced stage; therefore, it is associated with poor patient outcomes.
Priyakshi Kalita-de Croft, Shayna Sharma, Nihar Godbole, Gregory E. Rice, Carlos Salomon   +4 more
doaj   +1 more source

Emerging Technologies for Cancer Research: Towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models [PDF]

Current Medicinal Chemistry, 2018, 2021
In the present review, we describe three hot topics in cancer research such as circulating tumor cells, exosomes, and 3D environment models. The first section is dedicated to microfluidic platforms for detecting circulating tumor cells, including both affinity based methods that take advantage of antibodies and aptamers, and label free approaches ...
arxiv   +1 more source

A SARS-CoV-2 antigen rapid diagnostic test for resource limited settings

Scientific Reports, 2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19 disease. RT-qPCR has been the primary method of diagnosis; however, the required infrastructure is lacking in many developing countries and the virus has ...
Erica Frew, Douglas Roberts, Shelly Barry, Matthew Holden, Amanda Restell Mand, Emily Mitsock, Enqing Tan, Wei Yu, Johan Skog   +8 more
doaj   +1 more source

Extracellular Vesicles—New Players in Cell-to-Cell Communication in Gestational Diabetes Mellitus

Biomedicines, 2022
Research in extracellular vesicles (EVs) has contributed to a better understanding of physiological and pathophysiological conditions. Biologically active cargo, such as miRNAs and proteins, is critical in many different biological processes.
Carlos Palma, H. David McIntyre, Carlos Salomon   +2 more
doaj   +1 more source

A urine-based Exosomal gene expression test stratifies risk of high-grade prostate Cancer in men with prior negative prostate biopsy undergoing repeat biopsy

BMC Urology, 2020
Background Initial prostate biopsy often fails to identify prostate cancer resulting in patient anxiety, especially when clinical features such as prostate specific antigen (PSA) remain elevated, leading to the need for repeat biopsies.
James McKiernan, Mikkel Noerholm, Vasisht Tadigotla, Sonia Kumar, Phillipp Torkler, Grannum Sant, Jason Alter, Michael J. Donovan, Johan Skog   +8 more
doaj   +1 more source

Mesenchymal Stem Cells and Their Small Extracellular Vesicles as Crucial Immunological Efficacy for Hepatic Diseases

Frontiers in Immunology, 2022
Mesenchymal stem cell small extracellular vesicles (MSC-sEVs) are a priority for researchers because of their role in tissue regeneration. sEVs act as paracrine factors and carry various cargos, revealing the state of the parent cells and contributing to
Yuting Tang, Yuting Tang, Peipei Wu, Peipei Wu, Linli Li, Linli Li, Wenrong Xu, Wenrong Xu, Jiajia Jiang, Jiajia Jiang   +9 more
doaj   +1 more source

Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

Cells, 2020
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication. With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the characteristics of producer cells, exosomes can be utilized as cell-free ...
Dae Hyun Ha, Hyun-keun Kim, Joon Lee, Hyuck Hoon Kwon, Gyeong-Hun Park, Steve Hoseong Yang, Jae Yoon Jung, Hosung Choi, Jun Ho Lee, Sumi Sung, Yong Weon Yi, Byong Seung Cho   +11 more
doaj   +1 more source