Results 11 to 20 of about 94,365 (207)

Finding the Exosome [PDF]

, 2010
We describe the events surrounding the identification of the exosome complex and the subsequent early development of the field. Like many scientific discoveries, the initial identification and characterization ofthe exosome was based on a combination of skill, good fortune--and the availability of cutting edge technology.
Mitchell, Phil, Tollervey, David
core   +8 more sources

The RNA exosome and RNA exosome-linked disease [PDF]

RNA, 2017
The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for both processing and degradation of a variety of RNAs. Cofactors that associate with the RNA exosome likely dictate substrate specificity for this complex. Recently, mutations in genes encoding both structural subunits of the RNA exosome and its cofactors have been
Derrick J. Morton, Emily G. Kuiper, Stephanie K. Jones, Sara W. Leung, Anita H. Corbett, Milo B. Fasken   +5 more
openaire   +3 more sources

Exosomes and Atherogenesis [PDF]

Frontiers in Cardiovascular Medicine, 2021
Myocardial infarction and ischemic stroke are the leading causes of mortality worldwide. Atherosclerosis is their common pathological foundation. It is known that atherosclerosis is characterized by endothelial activation/injury, accumulation of inflammatory immune cells and lipid-rich foam cells, followed by the development of atherosclerotic plaque ...
Bingbing Lin, Juan Yang, Yuwei Song, Guohui Dang, Juan Feng, Juan Feng   +5 more
openaire   +3 more sources

Exosomes and Exosomal miRNA in Respiratory Diseases [PDF]

Mediators of Inflammation, 2016
Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs.
Shamila D. Alipoor, Esmaeil Mortaz, Johan Garssen, Masoud Movassaghi, Mehdi Mirsaeidi, Ian M. Adcock   +5 more
openaire   +7 more sources

CATALYTIC PROPERTIES OF THE EUKARYOTIC EXOSOME [PDF]

, 2010
The eukaryotic exosome complex is built around the backbone of a 9‑subunit ring similar to phosporolytic ribonucleases such as RNase PH and polynucleotide phosphorylase (PNPase).
María Eugenia Gas López, Bertrand Séraphin, Andrzej Dziembowski, Dziembowski, A, Gas López, Maria Eugenia, Dziembowski, Andrzej, Tomecki, R, Gas Lopez, Maria, Séraphin, Bertrand, Chlebowski, Aleksander, Tomecki, Rafał, Aleksander Chlebowski, Rafał Tomecki, Chlebowski, A   +13 more
core   +2 more sources

Exosomics

EMBnet.journal, 2020
Extracellular vesicles have been the focus of a large number of studies in the past five years. Exosomes, a subgroup of extracellular vesicles, are of particularly high interest because they partake in a wide number of biological pathways.  Produced by a variety of cells, exosomes have an important role in both physiological and pathological conditions.
Mitsis, Thanasis, Pierouli, Katerina, Diakou, Kalliopi Lo, Papakonstantinou, Eleni, Bacopoulou, Flora, Chrousos, George P., Vlachakis, Dimitrios   +6 more
openaire   +4 more sources

Coffee-Derived Exosome-Like Nanoparticles: Are They the Secret Heroes? [PDF]

, 2023
BACKGROUND: Regular coffee consumption has beneficial and preventative effects on liver and chronic neurodegenerative diseases. However, the studies performed with the ingredients found in coffee beverages have not clarified the responsible mechanisms ...
Gulsen Yildirim, Yurtsever Sarıca, Deniz, Dilara Fatma Akin Bali, Öztürk, Seçkin, Pınar Akpınar Oktar, Üstün Ezer, Zeynep Büşra Özer, Ezer, Üstün, Taşdelen, Serpil, Kürekçi, Ahmet Emin, Murat Kantarcioglu, Pinar Akpinar Oktar, Ahmet Emin Kürekçi, Kamil Can Akcali, Kantarcıoğlu, Murat, Murat Kantarcıoğlu, Kamil Can Akçalı, Yanbakan, Serpil, Yıldırım, Gülşen, Emel Bayrak, Bayrak, Emel, Akın Balı, Dilara Fatma, Akçalı, Kamil Can, Akpınar Oktar, Pınar, Gülşen Yıldırım, Deniz Yurtsever Sarıca, Serpil Yanbakan, Deniz Yurtsever Sarica, Dilara Fatma Akın Balı, Seçkin Öztürk, Serpil Taşdelen, Özer, Zeynep Büşra   +31 more
core   +1 more source

Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

Journal of Controlled Release, 2023
Exosomes are endosome-derived nanovesicles involved in cellular communication. They are natural nanocarriers secreted by various cells, making them suitable candidates for diverse drug delivery and therapeutic applications from a material standpoint. They have a phospholipid bilayer decorated with functional molecules and an enclosed parental matrix ...
Jagannath, Mondal, Shameer, Pillarisetti, Vijayabhaskarreddy, Junnuthula, Monochura, Saha, Seung Rim, Hwang, In-Kyu, Park, Yong-Kyu, Lee   +6 more
  +6 more sources

The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease [PDF]

Frontiers in Cell and Developmental Biology, 2021
Exosomes are small vesicles (30–150 nm in diameter) enclosed by a lipid membrane bilayer, secreted by most cells in the body. They carry various molecules, including proteins, lipids, mRNA, and other RNA species, such as long non-coding RNA, circular RNA, and microRNA (miRNA). miRNAs are the most numerous cargo molecules in the exosome.
Dongdong Zheng, Ming Huo, Bo Li, Weitie Wang, Hulin Piao, Yong Wang, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu   +9 more
openaire   +3 more sources

Mesenchymal Stem Cells and Their Small Extracellular Vesicles as Crucial Immunological Efficacy for Hepatic Diseases

Frontiers in Immunology, 2022
Mesenchymal stem cell small extracellular vesicles (MSC-sEVs) are a priority for researchers because of their role in tissue regeneration. sEVs act as paracrine factors and carry various cargos, revealing the state of the parent cells and contributing to
Yuting Tang, Yuting Tang, Peipei Wu, Peipei Wu, Linli Li, Linli Li, Wenrong Xu, Wenrong Xu, Jiajia Jiang, Jiajia Jiang   +9 more
doaj   +1 more source