Results 11 to 20 of about 88,162 (311)

The RNA exosome and RNA exosome-linked disease [PDF]

RNA, 2017
The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for both processing and degradation of a variety of RNAs. Cofactors that associate with the RNA exosome likely dictate substrate specificity for this complex. Recently, mutations in genes encoding both structural subunits of the RNA exosome and its cofactors have been
Derrick J. Morton, Emily G. Kuiper, Stephanie K. Jones, Sara W. Leung, Anita H. Corbett, Milo B. Fasken   +5 more
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Finding the Exosome [PDF]

, 2010
We describe the events surrounding the identification of the exosome complex and the subsequent early development of the field. Like many scientific discoveries, the initial identification and characterization ofthe exosome was based on a combination of skill, good fortune--and the availability of cutting edge technology.
Mitchell, Phil, Tollervey, David
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Exosomes and Atherogenesis [PDF]

Frontiers in Cardiovascular Medicine, 2021
Myocardial infarction and ischemic stroke are the leading causes of mortality worldwide. Atherosclerosis is their common pathological foundation. It is known that atherosclerosis is characterized by endothelial activation/injury, accumulation of inflammatory immune cells and lipid-rich foam cells, followed by the development of atherosclerotic plaque ...
Bingbing Lin, Juan Yang, Yuwei Song, Guohui Dang, Juan Feng, Juan Feng   +5 more
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Exosome-based smart drug delivery tool for cancer theranostics [PDF]

, 2023
 Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. The main activity of exosomes is cellular communication. In cancer, exosomes play an important rolefrom two distinct perspectives, one
Arabinda Ghosh (456208), Arikketh Devi (6317066), Nanasaheb Thorat (14790409), Rishav Kar (16532480), Rajib Dhar (16532483), Sagnik Nag (16532489), Sayantanee Mukherjee, (16532486), Nobendu Mukerjee (12152507), Anand Krishnan (238402), Dattatreya Mukherjee (14724423), Sukhamoy Gorai (16532497), Rishabh Vatsa (16532503), Mamtha Chandrakanth Jadhav (16532506)   +12 more
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Exosomes and Exosomal miRNA in Respiratory Diseases [PDF]

Mediators of Inflammation, 2016
Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs.
Shamila D. Alipoor, Esmaeil Mortaz, Johan Garssen, Masoud Movassaghi, Mehdi Mirsaeidi, Ian M. Adcock   +5 more
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HACE2-Exosome-Based Nano-Bait for Concurrent SARS-CoV2 Trapping and Antioxidant Therapy [PDF]

, 2022
Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seriously threatening human health.
Haiqing Dong, Shiyu Guo, Yao Liu, Xiaoyi Ma, Tianbin Ren, Yongyong Li (1261074), Maomao An, Xiaoyi Ma (4952629), Yushan Yang, Yongyong Li, Tianbin Ren (1780828), Maomao An (7351736), Yushan Yang (10975386), Yao Liu (173014), Haiqing Dong (1780822), Shiyu Guo (430733), Shuangrong Ruan, Jie Zang, Yan Li (23143), Jie Zang (728519), Shuangrong Ruan (7481618), Yan Li   +21 more
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Coffee-Derived Exosome-Like Nanoparticles: Are They the Secret Heroes? [PDF]

, 2023
BACKGROUND: Regular coffee consumption has beneficial and preventative effects on liver and chronic neurodegenerative diseases. However, the studies performed with the ingredients found in coffee beverages have not clarified the responsible mechanisms ...
Gulsen Yildirim, Yurtsever Sarıca, Deniz, Dilara Fatma Akin Bali, Öztürk, Seçkin, Pınar Akpınar Oktar, Üstün Ezer, Zeynep Büşra Özer, Ezer, Üstün, Taşdelen, Serpil, Kürekçi, Ahmet Emin, Murat Kantarcioglu, Pinar Akpinar Oktar, Ahmet Emin Kürekçi, Kamil Can Akcali, Kantarcıoğlu, Murat, Murat Kantarcıoğlu, Kamil Can Akçalı, Yanbakan, Serpil, Yıldırım, Gülşen, Emel Bayrak, Bayrak, Emel, Akın Balı, Dilara Fatma, Akçalı, Kamil Can, Akpınar Oktar, Pınar, Gülşen Yıldırım, Deniz Yurtsever Sarıca, Serpil Yanbakan, Deniz Yurtsever Sarica, Dilara Fatma Akın Balı, Seçkin Öztürk, Serpil Taşdelen, Özer, Zeynep Büşra   +31 more
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Exosomics

EMBnet.journal, 2020
Extracellular vesicles have been the focus of a large number of studies in the past five years. Exosomes, a subgroup of extracellular vesicles, are of particularly high interest because they partake in a wide number of biological pathways.  Produced by a variety of cells, exosomes have an important role in both physiological and pathological conditions.
Mitsis, Thanasis, Pierouli, Katerina, Diakou, Kalliopi Lo, Papakonstantinou, Eleni, Bacopoulou, Flora, Chrousos, George P., Vlachakis, Dimitrios   +6 more
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The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease [PDF]

Frontiers in Cell and Developmental Biology, 2021
Exosomes are small vesicles (30–150 nm in diameter) enclosed by a lipid membrane bilayer, secreted by most cells in the body. They carry various molecules, including proteins, lipids, mRNA, and other RNA species, such as long non-coding RNA, circular RNA, and microRNA (miRNA). miRNAs are the most numerous cargo molecules in the exosome.
Dongdong Zheng, Ming Huo, Bo Li, Weitie Wang, Hulin Piao, Yong Wang, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu   +9 more
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Reviving the Exosome [PDF]

Cell, 2005
In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et al.
Jensen, Torben Heick, Moore, Claire
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