Results 11 to 20 of about 97,752 (283)

The exosome journey: from biogenesis to uptake and intracellular signalling

Cell communication and signaling : CCS, 2021
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials testing exosomes for diagnostic and therapeutic applications are generating remarkable interest from the scientific community and investors.
Sonam Gurung, D. Perocheau, Loukia Touramanidou, J. Baruteau   +3 more
semanticscholar   +1 more source

Exosome engineering in cell therapy and drug delivery

InflammoPharmacology, 2023
Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the ...
Somaye Sadeghi, F. Tehrani, S. Tahmasebi, A. Shafiee, Seyed Mahmoud Hashemi   +4 more
semanticscholar   +1 more source

Current Strategies for Exosome Cargo Loading and Targeting Delivery

Cells, 2023
Extracellular vesicles (EVs) such as ectosomes and exosomes have gained attention as promising natural carriers for drug delivery. Exosomes, which range from 30 to 100 nm in diameter, possess a lipid bilayer and are secreted by various cells.
Haifeng Zeng, Shaoshen Guo, Xuanchen Ren, Zhenkun Wu, Shuwen Liu, Xingang Yao   +5 more
semanticscholar   +1 more source

miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury

Redox Biology, 2023
Background Sepsis is a fatal disease with a high rate of morbidity and mortality, during which acute lung injury is the earliest and most serious complication. Injury of pulmonary microvascular endothelial cells (PMVECs) induced by excessive inflammation
K. Shen, Xujie Wang, Yunwei Wang, Yanhui Jia, Yue Zhang, Kejia Wang, L. Luo, W. Cai, Jin Li, Shaohui Li, Yuting Du, Lixia Zhang, Hao Zhang, Yuxi Chen, Chaolei Xu, Jinxin Zhang, Ruizhi Wang, Xuekang Yang, Yunchuan Wang, Da-ming Hu   +19 more
semanticscholar   +1 more source

A urine-based Exosomal gene expression test stratifies risk of high-grade prostate Cancer in men with prior negative prostate biopsy undergoing repeat biopsy

BMC Urology, 2020
Background Initial prostate biopsy often fails to identify prostate cancer resulting in patient anxiety, especially when clinical features such as prostate specific antigen (PSA) remain elevated, leading to the need for repeat biopsies.
James McKiernan, Mikkel Noerholm, Vasisht Tadigotla, Sonia Kumar, Phillipp Torkler, Grannum Sant, Jason Alter, Michael J. Donovan, Johan Skog   +8 more
doaj   +1 more source

Extracellular Vesicles—New Players in Cell-to-Cell Communication in Gestational Diabetes Mellitus

Biomedicines, 2022
Research in extracellular vesicles (EVs) has contributed to a better understanding of physiological and pathophysiological conditions. Biologically active cargo, such as miRNAs and proteins, is critical in many different biological processes.
Carlos Palma, H. David McIntyre, Carlos Salomon   +2 more
doaj   +1 more source

Review on Strategies and Technologies for Exosome Isolation and Purification

Frontiers in Bioengineering and Biotechnology, 2022
Exosomes, a nano-sized subtype of extracellular vesicles secreted from almost all living cells, are capable of transferring cell-specific constituents of the source cell to the recipient cell.
Jiaci Chen, Peilong Li, Taiyi Zhang, Zhi-lei Xu, Xiaowen Huang, Ruiming Wang, Lutao Du   +6 more
semanticscholar   +1 more source

Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

Molecular Cancer, 2022
Exosomes are well-known key mediators of intercellular communication and contribute to various physiological and pathological processes. Their biogenesis involves four key steps, including cargo sorting, MVB formation and maturation, transport of MVBs ...
Qing-fang Han, Wenjia Li, K. Hu, Jie Gao, W. Zhai, Jinghan Yang, Shui-Jun Zhang   +6 more
semanticscholar   +1 more source

Exosome Processing and Characterization Approaches for Research and Technology Development

Advancement of science, 2022
Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents.
James J. Lai, Zoe L. Chau, Sheng-You Chen, John J. Hill, Katalin V. Korpany, Nai-Wen Liang, Li-Han Lin, Yi-Hsuan Lin, Joanne K Liu, Yu-Chung Liu, Ruby Lunde, Wei-Ting Shen   +11 more
semanticscholar   +1 more source

Mesenchymal Stem Cells and Their Small Extracellular Vesicles as Crucial Immunological Efficacy for Hepatic Diseases

Frontiers in Immunology, 2022
Mesenchymal stem cell small extracellular vesicles (MSC-sEVs) are a priority for researchers because of their role in tissue regeneration. sEVs act as paracrine factors and carry various cargos, revealing the state of the parent cells and contributing to
Yuting Tang, Yuting Tang, Peipei Wu, Peipei Wu, Linli Li, Linli Li, Wenrong Xu, Wenrong Xu, Jiajia Jiang, Jiajia Jiang   +9 more
doaj   +1 more source