Results 21 to 30 of about 182,132 (342)
Recent advances in exosome-mediated nucleic acid delivery for cancer therapy
Journal of Nanobiotechnology, 2022 Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity
Ying Zhang +10 more
semanticscholar +1 more source
Exosomes released from breast cancer carcinomas stimulate cell movement [PDF]
, 2015 For metastasis to occur cells must communicate with to their local environment to initiate growth and invasion. Exosomes have emerged as an important mediator of cell-to-cell signalling through the transfer of molecules such as mRNAs, microRNAs, and ...
Gucek, Marjan +5 more
core +8 more sources
Extracellular vesicles from plasma have higher tumour RNA fraction than platelets
Journal of Extracellular Vesicles, 2020 In addition to Circulating Tumour Cells (CTCs), cell-free DNA (cfDNA) and Extracellular Vesicles (EVs), the notion of “Tumour-Educated Platelets” (TEP) has recently emerged as a potential source of tumour-derived biomarkers accessible through blood ...
Kay Brinkman +6 more
doaj +1 more source
Regulation of exosome production and cargo sorting
International Journal on Biological Sciences, 2021 Cellular communication can be mediated by the exchange of biological information, mainly in the form of proteins and RNAs. This can occur when extracellular vesicles, such as exosomes, secreted by a donor cell are internalized by an acceptor cell ...
Hong Wei +11 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Loading human umbilical mesenchymal stem cell (hUMSC) derived exosomes onto hydrogel scaffolds is a strategy for rapid wound healing. The clinical application of exosomes is hindered by low production, and exosome mimetics could be substituted for ...
Jie Zhu +12 more
doaj +1 more source
Tumour exosome integrins determine organotropic metastasis
Nature, 2015 Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident ...
Ayuko Hoshino +53 more
semanticscholar +1 more source
Cells, 2019 The use of extracellular vesicles, specifically exosomes, as carriers of biomarkers in extracellular spaces has been well demonstrated. Despite their promising potential, the use of exosomes in the clinical setting is restricted due to the lack of ...
Laura M Doyle, Michael Zhuo Wang
semanticscholar +1 more source
Recent advances of emerging microfluidic chips for exosome mediated cancer diagnosis
Smart Materials in Medicine, 2021 Recent technological advances in the field of microfluidic chips have provided great opportunities to boost the development of exosome-based cancer diagnosis.
Le Wang +4 more
doaj +1 more source
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks [PDF]
, 2019 The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous ...
Bonath, Franziska +7 more
core +2 more sources
Nature Communications, 2021 Despite their roles in intercellular communications, the different populations of extracellular vesicles (EVs) and their secretion mechanisms are not fully characterized: how and to what extent EVs form as intraluminal vesicles of endocytic compartments (
Mathilde Mathieu +13 more
semanticscholar +1 more source