Results 41 to 50 of about 168,932 (404)
Stem Cell Research & Therapy, 2018 Exosomes are nano-sized vesicles (30–200 nm) constantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids, makes them an appealing cell-free therapy ...
Byong Seung Cho +3 more
doaj +1 more source
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks [PDF]
, 2019 The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous ...
Bonath, Franziska +7 more
core +2 more sources
Cells, 2020 Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Kyong-Oh Shin +19 more
doaj +1 more source
Theranostics, 2020 Exosomes are small extracellular vesicles with diameters of 30-150 nm. In both physiological and pathological conditions, nearly all types of cells can release exosomes, which play important roles in cell communication and epigenetic regulation by ...
Dongbin Yang +13 more
semanticscholar +1 more source
Journal of the American Society of Nephrology, 2015 Acute kidney injury, AKI, is relatively common in the hospital setting, and beyond the identification of the underlying cause and supportive measures, little can be done to facilitate healing of the compromised kidney.
Christopher J. Ward +1 more
openaire +3 more sources
Quantification of Exosomes [PDF]
Journal of Cellular Physiology, 2017 Exosomes are released by cells as self‐contained vesicles with an intact lipid bilayer that encapsulates a small portion of the parent cell. Exosomes have been studied widely as information‐rich sources of potential biomarkers that can reveal cellular physiology.
Robert A. Star +3 more
openaire +3 more sources
The role of the Arabidopsis Exosome in siRNA-independent silencing of heterochromatic loci. [PDF]
PLoS Genetics, 2013 The exosome functions throughout eukaryotic RNA metabolism and has a prominent role in gene silencing in yeast. In Arabidopsis, exosome regulates expression of a "hidden" transcriptome layer from centromeric, pericentromeric, and other heterochromatic ...
Jun-Hye Shin +5 more
doaj +1 more source
RNA Turnover: Unexpected Consequences of Being Tailed [PDF]
, 2005 In eukaryotic cells, the 3′ poly(A) tails found on mRNA influence their stability and translation. The discovery of a second nuclear poly(A) polymerase complex has fueled a series of reports defining a new and unexpected role for 3′ end poly(A) tails in ...
Anderson, James T.
core +2 more sources
RAB31 marks and controls an ESCRT-independent exosome pathway
Cell Research, 2020 Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal vesicles (ILVs) and secreted during the fusion of MVEs with the cell membrane. The mechanisms of exosome biogenesis remain poorly explored.
D. Wei +9 more
semanticscholar +1 more source
Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury [PDF]
Frontiers in Cell and Developmental Biology, 2021 Acute spinal cord injury (SCI) is a serious traumatic event to the spinal cord with considerable morbidity and mortality. This injury leads to short- and long-term variations in the spinal cord, and can have a serious effect on the patient’s sensory, motor, or autonomic functions.
Zhihan Zhu +5 more
openaire +4 more sources