Results 41 to 50 of about 182,132 (342)

Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. [PDF]

, 2016
The αvβ3 integrin is known to be highly upregulated during cancer progression and promotes a migratory and metastatic phenotype in many types of tumors.
Fedele, Carmine, Keen, James H., Languino, Lucia R., Lu, Huimin, Nevalainen, Marja T., Singh, Amrita   +5 more
core   +2 more sources

Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics

Theranostics, 2020
Exosomes are small extracellular vesicles with diameters of 30-150 nm. In both physiological and pathological conditions, nearly all types of cells can release exosomes, which play important roles in cell communication and epigenetic regulation by ...
Dongbin Yang, Weihong Zhang, Huanyun Zhang, Fengqiu Zhang, Lanmei Chen, Lixia Ma, Leon M Larcher, Suxiang Chen, Nan Liu, Qingxia Zhao, P. Tran, Changying Chen, R. Veedu, Tao Wang   +13 more
semanticscholar   +1 more source

Nanopillar and nanohole fabrication via mixed lithography

Materials Research Express, 2020
We report a fabrication method for the production of nanopillar (NP) or nanohole (NH) arrays together with a micrometer-sized structure within a single layer.
Seung Hee Baek, Sunwoong Lee, Ju-Hyun Bae, Chang-Won Hong, Mae-Ja Park, Hongsik Park, Moon-Chang Baek, Sung-Wook Nam   +7 more
doaj   +1 more source

A global function for transcription factors in assisting RNA polymerase II termination. [PDF]

, 2017
The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized.
Chanfreau, Guillaume F, Roy, Kevin
core   +1 more source

RAB31 marks and controls an ESCRT-independent exosome pathway

Cell Research, 2020
Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal vesicles (ILVs) and secreted during the fusion of MVEs with the cell membrane. The mechanisms of exosome biogenesis remain poorly explored.
D. Wei, Weixiang Zhan, Ying Gao, liyan Huang, Run Gong, Wen Wang, Ruhua Zhang, Yuanzhong Wu, Song Gao, Tiebang Kang   +9 more
semanticscholar   +1 more source

Defined MSC exosome with high yield and purity to improve regenerative activity

Journal of Tissue Engineering, 2021
Exosomes derived from mesenchymal stem cells (MSCs) have been studied as vital components of regenerative medicine. Typically, various isolation methods of exosomes from cell culture medium have been developed to increase the isolation yield of exosomes.
Jun Yong Kim, Won-Kyu Rhim, Yong-In Yoo, Da-Seul Kim, Kyoung-Won Ko, Yun Heo, Chun Gwon Park, Dong Keun Han   +7 more
doaj   +1 more source

Performance Evaluation of BD FACSPresto^TM Near-Patient CD4 Counter for Monitoring Antiretroviral Therapy in HIV-Infected Individuals in Primary Healthcare Clinics in Thailand

Diagnostics, 2022
HIV viral load is more reliable tool for monitoring treatment throughout the course of HIV/AIDS, but the test may be expensive in resource-limited settings. Therefore, enumeration of CD4 T-lymphocyte count remains important in these settings.
Kasama Sukapirom, Somrat Matchua, Charin Thepthai, Narinee Srimark, Ladawan Khowawisetsut, Kovit Pattanapanyasat   +5 more
doaj   +1 more source

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources

Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression

Signal Transduction and Targeted Therapy, 2020
Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy demands.
Enli Yang, Xuan Wang, Z. Gong, Mia Yu, Haiwei Wu, Dongsheng Zhang   +5 more
semanticscholar   +1 more source

An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency

Journal of Nanobiotechnology, 2022
Background Exosome mediated mRNA delivery is a promising strategy for the treatment of multiple diseases. However, the low yield of exosomes is a bottleneck for clinical translation.
Rongxin Zhang, Te Bu, Ruidan Cao, Zhelong Li, Chen Wang, Bing Huang, Mengying Wei, Lijun Yuan, Guodong Yang   +8 more
doaj   +1 more source