Results 61 to 70 of about 143,013 (333)

Identification of Immunoreactive Tumour Antigens Using Free and Exosome-Associated Humoral Responses

Journal of Circulating Biomarkers, 2013
Altered tumour antigens can initiate cellular and humoral immune responses; however, they often fail to eliminate tumours. In humans, the presence of cancer is generally associated with the suppression of T cell activation and effector responses ...
Carolyn D. Roberson, Cicek Gercel-Taylor, Ying Qi, Kevin L. Schey, Douglas D. Taylor   +4 more
doaj   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Proteomic analyses of Urine Exosomes reveal New Biomarkers of Diabetes in Pregnancy. [PDF]

, 2016
ObjectiveTo evaluate 24 hour urine exosome protein content changes among pregnant US subjects with diabetes and obesity during early pregnancy.MethodsThe exosome proteome content from 24 hour urine samples of pregnant subjects with gestational diabetes ...
Aghania, Eamon, Awdishu, Linda, Bounkhoun, Anousone, Ghassemian, Majid, Hamlin, Alyssa A, Ishaya, Michelle, Kao, Kelly, Khoshaba, Roni, Kokoy-Mondragon, Chanthel, Madrigal, Assael, Naviaux, Robert K, Overcash, Rachael, Proudfoot, James, Ramachandrarao, Satish P, Tarsa, Maryam, Zhou, Marcela   +15 more
core  

A new landscape of host–protozoa interactions involving the extracellular vesicles world [PDF]

, 2018
This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © Cambridge University Press 2018Extracellular vesicles (EVs) are released by a wide number of cells including ...
Bruno Gavinho, Combes, Dlugonska, Hart, Ingrid Evans-Osses, Izadora Volpato Rossi, Jameel Inal, Kho, Lechartier, Marcel I. Ramirez, Nten, Zingales   +11 more
core   +2 more sources

GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis [PDF]

, 2023
Yu Jin Lee, Kyeong Jin Shin, Hyun‐Jun Jang, Jin‐Sun Ryu, Chae Young Lee, Jong Hyuk Yoon, Jeong Kon Seo, Sabin Park, Semin Lee, A Reum Je, Yang Hoon Huh, Sun‐Young Kong, Taejoon Kwon, Pann‐Ghill Suh, Young Chan Chae   +14 more
openalex   +1 more source

Exosomal Epigenetics

EMBnet.journal
Epigenetics is the study of heritable changes in gene expression that occur without changes to the underlying DNA sequence. Epigenetic modifications can include DNA methylation, histone modifications, and non-coding RNAs, among others. These modifications can influence the expression of genes by altering the way DNA is packaged and accessed by ...
Papakonstantinou, Eleni, Dragoumani, Konstantina, Chrousos, George P, Vlachakis, Dimitrios   +3 more
openaire   +2 more sources

Emerging 2D Materials and Their Hybrid Nanostructures for Label‐Free Optical Biosensing: Recent Progress and Outlook

Advanced Functional Materials, EarlyView.
This review highlights recent advances in label‐free optical biosensors based on 2D materials and rationally designed mixed‐dimensional nanohybrids, emphasizing their synergistic effects and novel functionalities. It also discusses multifunctional sensing platforms and the integration of machine learning for intelligent data analysis.
Xinyi Li, Yonghao Fu, Yuehe Lin, Dan Du
wiley   +1 more source

Lysosomal Delivery of Bioactive Proteins to Living Human Cells via Engineered Exosomes [PDF]

, 2018
Exosomes are naturally secreted nanovesicles derived from mammalian cells that are used for intercellular communication in vivo. As a result, they can potentially be used for intracellular delivery of therapeutics for disease treatment. We have developed
Levy, Daniel
core   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus

Journal of Translational Medicine, 2021
Background Gestational diabetes mellitus (GDM) is a serious public health issue affecting 9–15% of all pregnancies worldwide. Recently, it has been suggested that extracellular vesicles (EVs) play a role throughout gestation, including mediating a ...
Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacós, Fátima Crispi, Gregory Duncombe, Martha Lappas, H. David McIntyre, Gregory Rice, Carlos Salomon   +18 more
doaj   +1 more source