Results 61 to 70 of about 202,955 (306)
Exosomes: Diagnostic and Therapeutic Implications in Cancer
Pharmaceutics, 2023 Exosomes are a subset of extracellular vesicles produced by all cells, and they are present in various body fluids. Exosomes play crucial roles in tumor initiation/progression, immune suppression, immune surveillance, metabolic reprogramming ...
Hyein Jo, Kyeonghee Shim, Dooil Jeoung
doaj +1 more source
Journal of Nanobiotechnology, 2020 Background5-Fluorouracil (5-FU) has been commonly prescribed for patients with colorectal cancer (CRC), but resistance to 5-FU is one of the main reasons for failure in CRC.
G. Liang +8 more
semanticscholar +1 more source
The RNA exosome and RNA exosome-linked disease [PDF]
RNA, 2017 The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for both processing and degradation of a variety of RNAs. Cofactors that associate with the RNA exosome likely dictate substrate specificity for this complex. Recently, mutations in genes encoding both structural subunits of the RNA exosome and its cofactors have been
Derrick J. Morton +5 more
openaire +3 more sources
Antibody-loading of biological nanocarrier vesicles derived from red-blood-cell membranes [PDF]
arXiv, 2023 Antibodies, disruptive potent therapeutic agents against pharmacological targets, face a barrier crossing immune-system and cellular-membranes. To overcome these, various strategies have been explored including shuttling via liposomes or bio-camouflaged nanoparticles.
arxiv
Plasmonic nano-aperture label-free imaging [PDF]
, 2020 Label-free observation of nanoparticles by far-field optical microscopy is challenging because their ability to scatter or absorb light dramatically diminishes with decreasing size. Surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) imaging have shown promises and respective limitations.
arxiv +1 more source
Application of exosomes as liquid biopsy in clinical diagnosis
Signal Transduction and Targeted Therapy, 2020 Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small extracellular vesicles with sizes between 30–150 nm.
Biting Zhou +7 more
semanticscholar +1 more source
Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. [PDF]
, 2016 The αvβ3 integrin is known to be highly upregulated during cancer progression and promotes a migratory and metastatic phenotype in many types of tumors.
Fedele, Carmine +5 more
core +2 more sources
Tumour exosomes display differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness [PDF]
Journal of Extracellular Vesicles, 2015 Background: Exosomes have been implicated in tumour progression and metastatic spread. Little is known of the effect of mechanical and innate immune interactions of malignant cell-derived exosomes on endothelial integrity, which may relate to increased ...
Bradley Whitehead +8 more
doaj +1 more source
Glioblastoma-Derived Exosomes as Nanopharmaceutics for Improved Glioma Treatment
Pharmaceutics, 2022 The use of cancer-derived exosomes has been studied in several cancer types, but the cancer-targeting efficacy of glioma-derived exosomes has not been investigated in depth for malignant glioblastoma (GBM) cells. In this study, exosomes were derived from
Hyeji Lee +7 more
doaj +1 more source
Proposal of Absolute Nanometer Size Measurement in Flow Cytometry Based on Laser Interferometry [PDF]
arXiv, 2021 The author discusses the laser interference method to measure the size of small bio-particles: extracellular vesicles (EVs), exosomes and viruses of nanometer scale in flow cytometry. By introducing a new laser configuration in place of conventional optical system of the flow cytometry, the interference fringe (periodic intensity modulation) is created
arxiv