Results 61 to 70 of about 222,944 (406)
Exosomes Facilitate Therapeutic Targeting of Oncogenic Kras in Pancreatic Cancer
Nature, 2017 The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes are extracellular vesicles generated by all cells, and are naturally present in the blood. Here we show that enhanced retention
S. Kamerkar +8 more
semanticscholar +1 more source
Cell Infectivity in relation to bovine leukemia virus gp51 and p24 in bovine milk exosomes. [PDF]
PLoS ONE, 2013 Exosomes are small membranous microvesicles (40-100 nm in diameter) and are extracellularly released from a wide variety of cells. Exosomes contain microRNA, mRNA, and cellular proteins, which are delivered into recipient cells via these exosomes, and ...
Tetsuya Yamada +3 more
doaj +1 more source
Exosomes: key players in cancer and potential therapeutic strategy
Signal Transduction and Targeted Therapy, 2020 Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long noncoding RNA, circular RNA, etc., which play a crucial role ...
J. Dai +9 more
semanticscholar +1 more source
, 2021 Exosomes are small extracellular vesicles released by cells under physiological and pathological conditions. There is emerging evidence associating exosomes with tumorigenesis. They carry cargo (DNA, RNA, miRNA and protein) pertaining to the cell of origin and play a key role in intercellular communication, influencing several cellular processes ...
José Miguel Amenábar +4 more
openaire +4 more sources
Mechanical characterization of cells and microspheres sorted by acoustophoresis with in-line resistive pulse sensing [PDF]
Phys. Rev. Applied 13, 034058 (2020), 2019 Resistive Pulse Sensing (RPS) is a key label-free technology to measure particles and single-cell size distribution. As a growing corpus of evidence supports that cancer cells exhibit distinct mechanical phenotypes from healthy cells, expanding the method from size to mechanical sensing could represent a pertinent and innovative tool for cancer ...
arxiv +1 more source
The RNA exosome and RNA exosome-linked disease [PDF]
RNA, 2017 The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for both processing and degradation of a variety of RNAs. Cofactors that associate with the RNA exosome likely dictate substrate specificity for this complex. Recently, mutations in genes encoding both structural subunits of the RNA exosome and its cofactors have been
Derrick J. Morton +5 more
openaire +3 more sources
Tumour exosomes display differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness [PDF]
Journal of Extracellular Vesicles, 2015 Background: Exosomes have been implicated in tumour progression and metastatic spread. Little is known of the effect of mechanical and innate immune interactions of malignant cell-derived exosomes on endothelial integrity, which may relate to increased ...
Bradley Whitehead +8 more
doaj +1 more source
Exosomes: Diagnostic and Therapeutic Implications in Cancer
Pharmaceutics, 2023 Exosomes are a subset of extracellular vesicles produced by all cells, and they are present in various body fluids. Exosomes play crucial roles in tumor initiation/progression, immune suppression, immune surveillance, metabolic reprogramming ...
Hyein Jo, Kyeonghee Shim, Dooil Jeoung
doaj +1 more source
Ultrasound-based Control of Micro-Bubbles for Exosome Delivery in Treating COVID-19 Lung Damage [PDF]
arXiv, 2021 The recent COVID-19 pandemic has resulted in high fatality rates, especially for patients who suffer from underlying health issues. One of the more serious symptoms exhibited from patients suffering from an acute COVID-19 infection is breathing difficulties and shortness of breath, which is largely due to the excessive fluid (cellular leakage and ...
arxiv
Journal of Nanobiotechnology, 2020 Background5-Fluorouracil (5-FU) has been commonly prescribed for patients with colorectal cancer (CRC), but resistance to 5-FU is one of the main reasons for failure in CRC.
G. Liang +8 more
semanticscholar +1 more source