Molecular cloning and expression of novel fibroblast growth factor-2 conjugated with immunodominant domains of pseudomonas exotoxin [PDF]
, 2015 Angiogenesis is very important in cancer growth and metastasis. Basic fibroblast growth factor (bFGF) as one of the most important angiogenesis factors is an attractive target for cancer vaccine.
Farazmandfar, T. +6 more
core +1 more source
The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. [PDF]
, 2011 BackgroundTumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro.
Broaddus, V Courtney +8 more
core +10 more sources
Phase I clinical study of the recombinant antibody toxin scFv(FRP5)-ETA specific for the ErbB2/HER2 receptor in patients with advanced solid malignomas [PDF]
, 2005 Introduction: ScFv(FRP5)-ETA is a recombinant antibody toxin with binding specificity for ErbB2 (HER2). It consists of an N-terminal single-chain antibody fragment (scFv), genetically linked to truncated Pseudomonas exotoxin A (ETA).
Gunter von Minckwitz +49 more
core +1 more source
BMC Infectious Diseases, 2021 Background Pseudomonas aeruginosa is the leading cause of nosocomial infections, especially in people with a compromised immune system. Targeting virulence factors by neutralizing antibodies is a novel paradigm for the treatment of antibiotic-resistant ...
Zahra Shadman +6 more
doaj +1 more source
"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? [PDF]
, 2007 Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway.
Medina-Kauwe, LK
core +1 more source
Prospect of using B. anthracis exotoxin in the design of anti-selective emergency preparations
Ukrainian Journal of Veterinary Sciences, 2022 The relevance of the study is conditioned upon the fact that outbreaks of anthrax are periodically recorded on the territory of Ukraine, not only in ruminants, but also in pigs, fur animals, dogs, and people.
Uliana Yanenko +4 more
doaj +1 more source
The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis [PDF]
, 2016 Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene.
Depluverez, Sofie +2 more
core +2 more sources
Control of the Colorado Potato Beetle (Coleoptera: Chrysomelidae) on Tomatoes with \u3ci\u3eBacillus Thuringiensis\u3c/i\u3e Var. \u3ci\u3eThuringiensis\u3c/i\u3e [PDF]
, 2017 (excerpt) The Colorado potato beetle, Leptinotarsa decemlineata (Say), is a serious pest of tomatoes grown in this country. This beetle is also developing resistance to several classes of chemical insecticides including most of the carbamates ...
Cantelo, W. W, Cantwell, G. E
core +2 more sources
Microfluidics-based liquid chromatography/mass spectrometry multiple reaction monitoring approach for the relative quantification of Burkholderia cenocepacia secreted virulence factors [PDF]
, 2018 Rationale: Burkholderia cenocepacia is an opportunistic pathogen that is commonly isolated from patients with cystic fibrosis (CF). Quorum sensing has been suggested to play a role in the activity of type II and type VI secretion systems and the release ...
Daled, Simon +6 more
core +2 more sources
Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus [PDF]
, 2017 Background: A group A Streptococcus (GAS) lineage of genotype emm3, sequence type 15 (ST15) was associated with a six month upsurge in invasive GAS disease in the UK.
Afshar, B +8 more
core +3 more sources