Results 11 to 20 of about 113,929,087 (168)

Pseudomonas infection: exotoxin A effect [PDF]

Саратовский научно-медицинский журнал, 2014
The aim of the article is to present the data analysis of the Russian and foreign literature concerning the current situation of the problem, the frequency and mechanisms of pseudomonas infection development and factors of patho-genicity of Pseudomonas ...
Morrison A.V., Popovich V.I., Morrison V.V..   +2 more
doaj   +1 more source

Exotoxin A Pseudomonas aeruginosa influence on working efficiency of white rats [PDF]

Саратовский научно-медицинский журнал, 2017
Objective: to study exotoxin A Pseudomonas aeruginosa influence on physical and mental efficiency of white rats. Material and Methods. The experiments were carried out on white rats following intraperitoneal injections of exotoxin A Pseudomonas of ...
Morrison V.V., Popovich V.I., Vasyutina V.O., Morrison A.V.   +3 more
doaj   +1 more source

Effect of Pseudomonas aeruginosa Pure Exotoxin A on Mice WBC in Comparison with Human WBC Contaminated by Pseudomonas aeruginosa

Armaghane Danesh Bimonthly Journal, 2008
Introduction & Objective: Pseudomonas aeruginosa is a gram negative bacterial. This bacterium is resistant to many antibiotics and chemical disinfectants.
M Naghmachi, A Sharifi, J Kohanteb
doaj   +1 more source

Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in dynamics: an animal model in white mice [PDF]

Саратовский научно-медицинский журнал, 2015
Purpose: to study biochemical indices of peripheral blood which show organs functional changes. Material and Methods. The experiments were carried out on white mice in dynamics development of pseudomonas aeruginosa caused by intraperitoneal injection of ...
Morrison A.V., Popovich V.I., Morrison V.V.   +2 more
doaj   +1 more source

Exotoxin-Targeted Drug Modalities as Antibiotic Alternatives

, 2022
The paradigm of antivirulence therapy dictates that bacterial pathogens are specifically disarmed but not killed by neutralizing their virulence factors. Clearance of the invading pathogen by the immune system is promoted. As compared to antibiotics, the
Moona Sakari (12024012), Moona Sakari, Arttu Laisi (12024015), Arto T. Pulliainen (8284056), Arto T. Pulliainen, Arttu Laisi   +5 more
core   +1 more source

Bacterial Exotoxins and the Inflammasome [PDF]

Frontiers in Immunology, 2015
The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18.
Greaney, Allison J., Leppla, Stephen H., Moayeri, Mahtab   +2 more
openaire   +3 more sources

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
J Michael Lord, Lord, Mike, Spooner, Robert A., Smith, Daniel C., Daniel C Smith, Roberts, L. M. (Lynne M.), Andrew J Easton, Easton, A. J. (Andrew J.), Robert A Spooner, Lynne M Roberts   +9 more
core   +1 more source

Isolation and characterizations of a novel recombinant scFv antibody against exotoxin A of Pseudomonas aeruginosa

BMC Infectious Diseases, 2021
Background Pseudomonas aeruginosa is the leading cause of nosocomial infections, especially in people with a compromised immune system. Targeting virulence factors by neutralizing antibodies is a novel paradigm for the treatment of antibiotic-resistant ...
Zahra Shadman, Safar Farajnia, Mohammad Pazhang, Mohammadreza Tohidkia, Leila Rahbarnia, Saeed Najavand, Sayna Toraby   +6 more
doaj   +1 more source

Superantigenic Activity of emm3 Streptococcus pyogenes Is Abrogated by a Conserved, Naturally Occurring smeZ Mutation [PDF]

, 2012
Streptococcus pyogenes M/emm3 strains have been epidemiologically linked with enhanced infection severity and risk of streptococcal toxic shock syndrome (STSS), a syndrome triggered by superantigenic stimulation of T cells. Comparison of S.
McGregor, Karen, Davies, F.J., Frances J Davies, Chong, Deborah L. W., McGregor, K., Davies, Frances J., McGregor, K, Leili Farzaneh, Spratt, BG, Leili Farzaneh (130255), Pichon, B., Shiranee Sriskandan, Efstratiou, A, McGregor Karen, Bruno Pichon (130249), Pichon, B, Holden, Matthew T. G., Davies, FJ, Mary Sommerlad, Androulla Efstratiou, Turner, CE, Sommerlad, M, Chong, DLW, Sriskandan Shiranee, Mary Sommerlad (130242), Sommerlad, M., Turner Claire E., Farzaneh, L., Brian G Spratt, Deborah L. W. Chong (130252), Brian G. Spratt (10001), Sriskandan, Shiranee, Holden, M.T., Holden, MTG, Matthew T G Holden, Sriskandan, S., Androulla Efstratiou (130260), Sommerlad Mary, Matthew T. G. Holden (130258), Pichon Bruno, Frances J. Davies (130247), Spratt, B.G., Shiranee Sriskandan (16154), Holden Matthew T. G., Karen McGregor (130245), Chong Deborah L. W., Turner, C.E., Karen McGregor, Sommerlad, Mary, Farzaneh, L, Sriskandan, S, Claire E Turner, Davies Frances J., Pichon, Bruno, Efstratiou, A., Farzaneh, Leili, Spratt Brian G., Claire E. Turner (130239), Spratt, Brian G., Efstratiou, Androulla, Efstratiou Androulla, Chong, D.L., Deborah L W Chong, Bruno Pichon, Farzaneh Leili, Turner, Claire E.   +65 more
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Exotoxin [PDF]

, 1989
Pseudornonas pseudomallei exotoxin was found to be a potent inhibitor of protein and DNA synthesis in cultured macrophages. Inhibition of DNA synthesis occurred at toxin concentrations as low as 1–2 μg/ml and inhibition of 3H~thymidine uptake was almost ...
Nathan, Sheila, Noor Embi, Nyonya Razak, Sheila Nathan, Mohamed, Rahmah, Embi, Noor, Ghazally Ismail, Rahmah Mohamed, Razak, Nyonya, Ismail, Ghazally   +9 more
core   +1 more source