Results 31 to 40 of about 113,929,087 (168)

Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis [PDF]

, 2007
Streptococcal pyrogenic exotoxin B is an extracellular cysteine protease. Only nephritis-associated strains of group A streptococci secrete this protease and this may be involved in the pathogenesis of post-streptococcal glomerulonephritis.
Kuo, C.-F., Chuang, W.-J., Lin, M.T., Lin, C.-F., Lin, Y.-S., Huang, K.-J., Lei, H.-Y., Liu, C.-C., Luo, Y.-H., Wu, J.-J.   +9 more
core   +1 more source

Cellular and physiological effects of anthrax exotoxin and its relevance to disease

Frontiers in Cellular and Infection Microbiology, 2012
Bacillus anthracis, the causative agent of anthrax, secretes a tripartite exotoxin that exerts pleiotropic effects on the host. The purification of the exotoxin components, protective antigen, lethal factor, and edema factor allowed the rapid ...
David Edward Lowe, Ian Justin Glomski
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Exotoxins ofStaphylococcus aureus [PDF]

Clinical Microbiology Reviews, 2000
SUMMARYThis article reviews the literature regarding the structure and function of two types of exotoxins expressed by Staphylococcus aureus, pyrogenic toxin superantigens (PTSAgs) and hemolysins. The molecular basis of PTSAg toxicity is presented in the context of two diseases known to be caused by these exotoxins: toxic shock syndrome and ...
M M, Dinges, P M, Orwin, P M, Schlievert
openaire   +2 more sources

Peptides tested for exotoxin synthesis inhibition activity.

, 2014
Peptides tested for exotoxin synthesis inhibition activity.
Joseph A. Merriman (201908), Patrick M. Schlievert (151266), Kimberly A. Nemeth (586775)   +2 more
core   +1 more source

Screening for staphylococcal superantigen genes shows no correlation with the presence or the severity of chronic rhinosinusitis and nasal polyposis. [PDF]

PLoS ONE, 2010
BACKGROUND: Staphylococcus aureus secretes numerous exotoxins which may exhibit superantigenic properties. Whereas the virulence of several of them is well documented, their exact biological effects are not fully understood.
Frédéric Heymans, Adrien Fischer, Nicholas W Stow, Myriam Girard, Zacharias Vourexakis, Antoine Des Courtis, Gesuele Renzi, Elzbieta Huggler, Stefan Vlaminck, Pierre Bonfils, Ranko Mladina, Valerie Lund, Jacques Schrenzel, Patrice François, Jean Silvain Lacroix   +14 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Staphylococcal and Streptococcal Superantigen Exotoxins [PDF]

Clinical Microbiology Reviews, 2013
SUMMARYThis review begins with a discussion of the large family ofStaphylococcus aureusand beta-hemolytic streptococcal pyrogenic toxin T lymphocyte superantigens from structural and immunobiological perspectives. With this as background, the review then discusses the major known and possible human disease associations with superantigens, including ...
Adam R, Spaulding, Wilmara, Salgado-Pabón, Petra L, Kohler, Alexander R, Horswill, Donald Y M, Leung, Patrick M, Schlievert   +5 more
openaire   +2 more sources

Fragment prediction and validation for exotoxin A.

, 2014
A) Fragment 2331 (benzamide) and the microenvironments from the query exotoxin A structure associated with the fragment prediction. B) PDB ligand P34 and an alternate structure of exotoxin A bound to P34. The benzamide substructure of P34 is in pink.
Russ B. Altman (6158), Grace W. Tang (535548)   +1 more
core   +1 more source