Antibodies are effective alternative tools to combat infections caused by Pseudomonas aeruginosa (PA), especially multi-drug-resistant PA. Thus, to solve the urgent need for an anti-PA antibody drug, we hypothesized that anti-PA intravenous ...
Jin Zhang +10 more
doaj +1 more source
Cancer is one of the prominent causes of death worldwide. Despite the existence of various modalities for cancer treatment, many types of cancer remain uncured or develop resistance to therapeutic strategies.
Seyed Mehdi Havaei +2 more
doaj +1 more source
Exotoxins ofStaphylococcus aureus [PDF]
SUMMARYThis article reviews the literature regarding the structure and function of two types of exotoxins expressed by Staphylococcus aureus, pyrogenic toxin superantigens (PTSAgs) and hemolysins. The molecular basis of PTSAg toxicity is presented in the context of two diseases known to be caused by these exotoxins: toxic shock syndrome and ...
M M, Dinges, P M, Orwin, P M, Schlievert
openaire +2 more sources
Development and validation of an ELISA to detect antibodies to Corynebacterium pseudotuberculosis in ovine sera [PDF]
Several enzyme-linked immunosorbent assays (ELISAs) have been developed for the detection of antibodies to Corynebacterium pseudotuberculosis, the causative agent of caseous lymphadenitis (CLA). However, none are commercially available in the UK.
Bailey, Mick +2 more
core +5 more sources
The exotoxins ofCorynebacterium ulcerans [PDF]
SummaryThe exotoxins produced by ten strains ofC. ulcerans(two human, six bovine and two equine) have been studied. On the criteria of toxin–antitoxin neutralisation and immunoprecipitation tests using highly specific diphtheria andC. ovisantitoxins with crude toxic filtrates, (NH4)2SO4concentrates, and partially purified chromatographic preparations ...
H R, Carne, E O, Onon
openaire +2 more sources
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
Screening for staphylococcal superantigen genes shows no correlation with the presence or the severity of chronic rhinosinusitis and nasal polyposis. [PDF]
BACKGROUND: Staphylococcus aureus secretes numerous exotoxins which may exhibit superantigenic properties. Whereas the virulence of several of them is well documented, their exact biological effects are not fully understood.
Frédéric Heymans +14 more
doaj +1 more source
Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li +17 more
wiley +1 more source
Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3 - Implications for the evolution of staphylococcal pathogenicity islands [PDF]
We describe the complete sequence of the 15.9-kb staphylococcal pathogenicity island 3 encoding staphylococcal enterotoxin serotypes B, K, and Q. The island, which meets the generally accepted definition of pathogenicity islands, contains 24 open reading
Kapur, Vivek +5 more
core
Clonal complexes and diversity of exotoxin gene profiles in methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates from patients in a Spanish hospital [PDF]
This work was supported by project FIS-06-PI052489 from the Spanish Ministry of Science and Innovation and projects BfR 45-004 and 45-005 of the Federal Institute for Risk Assessment (BfR), Germany. M.A.Argudín is the recipient of grant FPU AP 2004-3641
Argudín Regueiro, María Ángeles +5 more
core +1 more source

