Results 51 to 60 of about 113,929,087 (168)
Clinical Pharmacology &Therapeutics, EarlyView.Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu +15 more
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The exotoxins ofCorynebacterium ulcerans [PDF]
Journal of Hygiene, 1982 SummaryThe exotoxins produced by ten strains ofC. ulcerans(two human, six bovine and two equine) have been studied. On the criteria of toxin–antitoxin neutralisation and immunoprecipitation tests using highly specific diphtheria andC. ovisantitoxins with crude toxic filtrates, (NH4)2SO4concentrates, and partially purified chromatographic preparations ...
H R, Carne, E O, Onon
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Identification of peptide inhibitors of Pseudomonas aeruginosa exotoxin A function [PDF]
, 2000 Pseudomonas aeruginosa' is an opportunistic pathogen that can cause lethal infections in immunocompromised hosts. It is resistant to a wide variety of antibiotics, thus new strategies are needed to control its pathogenicity.
Thompson, Crista
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Antibody kinetics against tetanus toxoid before and after primary vaccination of foals
Equine Veterinary Journal, EarlyView.Abstract Background Vaccination recommendations for foals against Clostridium tetani vary. Available studies assessing foal immune responses, maternal antibody interference, or individual variation often used small foal numbers. Objectives To quantify antibody responses after tetanus vaccination in foals and explore associations with passively ...
Katharina Olbrich +2 more
wiley +1 more source
LINK BETWEEN SOME VIRULNCE FACTORS GENES AND ANTIBACTERIAL RESISTANCE OF PSEUDOMONAS AERUGINOSA
The Iraqi Journal of Agricultural science, 2022 The research was aimed to demonstrate the frequency of virulence factors genes (exoenzyme S and exotoxin A) and to express their relationship to antibacterial resistance among Pseudomonas aeruginosa isolated from patients suffering from otitis externa ...
Aida H. Ibrahim
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Allergy, EarlyView.ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe +24 more
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Histopathological Changes of Some Internal Organs of Mice Injected with Exotoxin a at Low Concentrations [PDF]
, 2014 Exotoxin A is the most lethal virulence factor produced by Pseudomonas aeruginosa. It inhibits elongation factor-2 by ADP-ribosylation of EF2. This causes stop of the elongation of polypeptides.
Majeed, Shatha Zuheir +3 more
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Toxins, 2017 Pseudomonas aeruginosa exotoxin A (PEA) causes severe hepatotoxicity in experimental animals and is useful in investigations of immune-mediated liver injury.
Chien-Chao Chiu +7 more
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Journal of Periodontal Research, EarlyView.This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali +3 more
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Pseudomonas exotoxin: chimeric toxins
Journal of Biological Chemistry, 1989 Pseudomonas exotoxin binds to and enters cells by receptor-mediated endocytosis. Within the cell it requires exposure to low pH to enable it to translocate to the cell cytoplasm where it inhibits protein synthesis by ADP-ribosylating elongation factor 2.
I, Pastan, D, FitzGerald
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