Results 41 to 50 of about 113,929,087 (168)

Environmental reservoirs of phage-encoded exotoxin genes [PDF]

, 2011
Exotoxins are virulence factors produced by some bacteria and are sometimes encoded by mobile genetic elements like bacteriophage (phage). Phage are viruses of bacteria that carry genetic information and through horizontal gene transfer this genetic ...
Casas, Veronica
core   +1 more source

Active immunization using exotoxin A confers protection against Pseudomonas aeruginosa infection in a mouse burn model

BMC Microbiology, 2009
Background Pseudomonas aeruginosa is an important cause of nosocomial infection and may lead to septicemia and death. We evaluated the immunogenicity of semi-purified exotoxin A from the bacterium in a mouse burn model.
Naghmachi Mohsen, Amini Masoud, Japoni Aziz, Mehrabani Davood, Kohanteb Jamshid, Manafi Ali, Zaghi Ahmad Hosseinzadeh, Khalili Nazanin   +7 more
doaj   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Towards Engineering Novel PE-Based Immunotoxins by Targeting Them to the Nucleus

Toxins, 2016
Exotoxin A (PE) from Pseudomonas aeruginosa is a bacterial ADP-ribosyltransferase, which can permanently inhibit translation in the attacked cells. Consequently, this toxin is frequently used in immunotoxins for targeted cancer therapies.
Marta Borowiec, Michal Gorzkiewicz, Joanna Grzesik, Aurelia Walczak-Drzewiecka, Anna Salkowska, Ewelina Rodakowska, Kamil Steczkiewicz, Leszek Rychlewski, Jaroslaw Dastych, Krzysztof Ginalski   +9 more
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Superantigens: Comparative Study of Streptococcal Mitogenic Exotoxin Z and Pyrogenic Exotoxin A

, 2001
Streptococcal mitogenic exotoxin Z (SMEZ), a superantigen derived from Streptococcus pyogenes, provoked expansion of human lymphocytes expressing the Vbeta 2, 4, 7 and 8 motifs of T-cell receptor.
Cavaillon, JM, Thomas M. Zollner, Joseph E. Alouf, Geoffroy-Fauvet, C, Desreumaux, P, Heide Müller-Alouf, Catherine Fitting, Champagne, E, Dieter Gerlach, Gerlach, D, Zollner, TM, Mueller-Alouf, H, Proft, Thomas, Alouf, JE, Jean-Marc Cavaillon, Eric Champagne, Thomas Proft, Christiane Geoffroy-Fauvet, Fitting, C, Pierre Desreumaux   +19 more
core   +1 more source

Effect of Pseudomonas aeruginosa exotoxin A on inner ear function

, 1997
Electrophysiological changes were studied in the albino rat following instillation of Pseudomonas aeruginosa exotoxin A into the middle ear cavity through the tympanic membrane.
Pettersson, Åke,, Stenqvist, Monika,, Anniko, Matti,   +2 more
core   +7 more sources

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

Nature Communications, 2018
The cellular toxicity of Pseudomonas exotoxin-S and -T depends on their activation by 14-3-3 but the underlying molecular mechanism is not fully understood.
Tobias Karlberg, Peter Hornyak, Ana Filipa Pinto, Stefina Milanova, Mahsa Ebrahimi, Mikael Lindberg, Nikolai Püllen, Axel Nordström, Elinor Löverli, Rémi Caraballo, Emily V. Wong, Katja Näreoja, Ann-Gerd Thorsell, Mikael Elofsson, Enrique M. De La Cruz, Camilla Björkegren, Herwig Schüler   +16 more
doaj   +1 more source

Population Genomics of emm4 Group A Streptococcus Reveals Progressive Replacement with a Hypervirulent Clone in North America

mSystems, 2021
Clonal replacement is a major driver for changes in bacterial disease epidemiology. Recently, it has been proposed that episodic emergence of novel, hypervirulent clones of group A Streptococcus (GAS) results from acquisition of a 36-kb DNA region ...
Sruti DebRoy, Misu Sanson, Brittany Shah, Shirjana Regmi, Luis Alberto Vega, Chioma Odo, Pranoti Sahasrabhojane, Allison McGeer, Gregory J. Tyrrell, Nahuel Fittipaldi, Samuel A. Shelburne, Anthony R. Flores   +11 more
doaj   +1 more source

Real time in vivo efficacy monitoring of desialylation and perforation enhanced immunotherapy of cancer

BMEMat, EarlyView.
A multifunctional nanomedicine is designed to engineer NK cells for enhanced cancer immunotherapy through perforation and desialylation, enabling real‐time monitoring of ATP and GrB levels for precise efficacy assessment. Abstract Efficient enhanced NK cell therapy is of critical importance in the immune treatment of cancer.
Yuanjiao Yang, Yuru Wang, Xuemei Li, Chaoyi Yang, Yuhui Yang, Yanyun Fang, Lin Ding, Yunlong Chen, Huangxian Ju   +8 more
wiley   +1 more source