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Experimental Autoimmune Encephalomyelitis
2021Experimental autoimmune encephalomyelitis, originally experimental allergic encephalomyelitis, is the well-known animal model of multiple sclerosis, an immune- mediated, demyelinating, inflammatory chronic disease of the central nervous system. The experimental disease is widely utilized to test new therapies in preclinical studies, to investigate new ...
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Experimental autoimmune encephalomyelitis [PDF]
, 1995 Experimental Autoimmune Encephalomyelitis (EAE) is the prototype for cell-mediated autoimmune disease in general, and is the best animal model of human CNS inflammatory demyelinating disease. It has three forms, which vary in clinical course and neuropathology: acute EAE, hyperacute EAE and chronic relapsing EAE.
Pamela A. McCombe, Michael P. Pender
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Experimental Autoimmune Encephalomyelitis in the Rat
Current Protocols in Immunology, 1996AbstractThis unit details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP).
Robert H. Swanborg, Jolie A. Stepaniak
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Experimental Autoimmune Encephalomyelitis in the Rat
Current Protocols in Immunology, 2009AbstractThere are several diverse rat models of experimental autoimmune encephalomyelitis (EAE) that can be used to investigate the pathogenesis and regulation of autoimmunity against CNS myelin. The disease course of these models ranges from an acute monophasic disease with limited demyelination to a chronic relapsing or chronic progressive course ...
Mark, Mannie +2 more
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Genetics of Experimental Autoimmune Encephalomyelitis
1999The genetic basis for susceptibility to experimental autoimmune encepha- lomyelitis (EAE) has been the subject of intense study for several decades. In spite of this long history, however, the eVort has only yielded small hints and contradictory leads to which genes influence susceptibility to this autoimmune disease.
JeVrey A. Encinas, Vijay K. Kuchroo
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Inheritance of susceptibility to experimental autoimmune encephalomyelitis
Journal of Neuroscience Research, 1996Experimental autoimmune encephalomyelitis is a disease of the central nervous system that can be readily induced in a variety of species by immunization with myelin proteins. It is one of the most commonly studied models of cell-mediated autoimmune disease and consequently has been important in the elucidation of many immunological functions in vivo ...
Howard L. Weiner +2 more
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Gene Therapy in Experimental Autoimmune Encephalomyelitis
Journal of Clinical Immunology, 2000Gene therapy traditionally has been associated with "gene replacement." where exogenous recombinant DNA is introduced ex vivo into somatic cells that are then introduced back into the patient as a way to correct an inherited genetic defect. However, several novel gene therapy strategies for treating autoimmune diseases recently have emerged. Strategies
Vincent K. Tuohy, Peter M. Mathisen
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Experimental Autoimmune Encephalomyelitis in Marmosets
2014Experimental autoimmune encephalomyelitis (EAE) in the common marmoset, a small-bodied Neotropical primate, is a well-known and validated animal model for multiple sclerosis (MS). This model can be used for exploratory research, i.e., investigating the pathogenic mechanisms involved in MS, and applied research, testing the efficacy of new potential ...
Bert A. 't Hart +4 more
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Experimental Autoimmune Encephalomyelitis in Primates
2008Due to their genetic and immunological proximity to humans, the common marmoset, Callithrix jacchus, provides an important bridge between rodent-based research and the human disease. Experimental autoimmune encephalomyelitis (EAE) induced in the outbred common marmoset provides a highly reproducible model of multiple sclerosis (MS) phenotypically ...
Smith, Paul A. +2 more
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Role of orexin-A in experimental autoimmune encephalomyelitis
Journal of Neuroimmunology, 2016The aim of this study was to evaluate the effects of orexin-A (OX-A) on behavioral and pathological parameters and on gene expression of some multiple sclerosis-related peptides in a model of experimental autoimmune encephalomyelitis (EAE). EAE was induced by subcutaneous administration of MOG 35-55.
Manijeh Motevalian +6 more
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