Results 241 to 250 of about 83,143 (262)

Neuroendocrine Influences on Experimental Autoimmune Encephalomyelitis

Annals of the New York Academy of Sciences, 1998
Abstract: Experimental autoimmune encephalomyelitis (EAE), a model for human multiple sclerosis, is an inflammatory disease of the CNS mediated by autoreactive T lymphocytes directed against the neuroantigen, myelin basic protein (MBP). EAE is inducible in the Lewis rat, which exhibits an acute monophasic disease, and in selected mouse strains, which ...
C C, Whitacre, K, Dowdell, A C, Griffin
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Gene Therapy in Experimental Autoimmune Encephalomyelitis

Journal of Clinical Immunology, 2000
Gene therapy traditionally has been associated with "gene replacement." where exogenous recombinant DNA is introduced ex vivo into somatic cells that are then introduced back into the patient as a way to correct an inherited genetic defect. However, several novel gene therapy strategies for treating autoimmune diseases recently have emerged. Strategies
P M, Mathisen, V K, Tuohy
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Experimental Autoimmune Encephalomyelitis in the Rat

Current Protocols in Immunology, 1996
AbstractThis unit details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP).
Robert H, Swanborg, Jolie A, Stepaniak
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Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2019
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS.
Natalia S, Novikova, Anastasia S, Diatlova, Kristina Z, Derevtsova, Elena A, Korneva, Tamara V, Viktorovna, Yuri, Ostrinki, Lital, Abraham, Shir, Quinn, Yahel, Segal, Leonid P, Churilov, Miri, Blank, Yehuda, Shoenfeld, Rina, Aharoni, Howard, Amital   +13 more
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Experimental autoimmune encephalomyelitis

1995
Experimental Autoimmune Encephalomyelitis (EAE) is the prototype for cell-mediated autoimmune disease in general, and is the best animal model of human CNS inflammatory demyelinating disease. It has three forms, which vary in clinical course and neuropathology: acute EAE, hyperacute EAE and chronic relapsing EAE.
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Behavioral aspects of experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2000
Acute inflammation is known to induce a depressive-like sickness behavior syndrome in humans and in experimental animals. In the present study, we sought to determine whether a chronic neuroautoimmune inflammation is also associated with a similar behavioral syndrome.
Y, Pollak, H, Ovadia, I, Goshen, R, Gurevich, K, Monsa, R, Avitsur, R, Yirmiya   +6 more
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Experimental Autoimmune Encephalomyelitis in the Mouse

Current Protocols in Immunology, 2010
AbstractThis unit details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP).
Stephen D, Miller, William J, Karpus, Todd Scott, Davidson   +2 more
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Experimental Murine Autoimmune Encephalomyelitis

1979
Experimental autoimmune (allergic) encephalomyelitis is an inflammatory and demyelinating disease of the central nervous system (CNS) mediated by the cellular component of the immune response. EAE is induced in laboratory animals when CNS tissue homogenates or myelin are injected together with oil adjuvants containing mycobacteria (Freund’s complete ...
D. S. Linthicum, I. R. Mackay, P. R. Carnegie   +2 more
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Keratan sulfate exacerbates experimental autoimmune encephalomyelitis

Journal of Neuroscience Research, 2015
Proteoglycans (PGs) are the components of extracellular matrices in the central nervous system (CNS). Keratan sulfate (KS) is a glycosaminoglycan that is included in the KSPG that acts as an inhibitory factor in nerve regeneration after CNS injury. To investigate the role of KS in immune diseases, we induced experimental autoimmune encephalomyelitis ...
Rino, Ueno, Katsuichi, Miyamoto, Noriko, Tanaka, Kota, Moriguchi, Kenji, Kadomatsu, Susumu, Kusunoki   +5 more
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Oral Tolerance in Experimental Autoimmune Encephalomyelitis

Annals of the New York Academy of Sciences, 1996
In work performed by a number of laboratories, it has become quite clear that the oral administration of autoantigens exerts a profoundly suppressive effect on the development and long-term clinical course of autoimmune disease. Specific peptide sequences derived from the autoantigens are similarly suppressive.
C C, Whitacre, I E, Gienapp, A, Meyer, K L, Cox, N, Javed   +4 more
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