Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis [PDF]
Journal of Immunology Research, 2021 The production of ergosterol lipid involves the activity of different enzymes and is a crucial event for the Leishmania membrane homeostasis. Such enzymes can be blocked by azoles and allylamines drugs, such as the antifungal butenafine chloride.
Adriana Bezerra-Souza +5 more
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Activity of Amphotericin B-Loaded Chitosan Nanoparticles against Experimental Cutaneous Leishmaniasis [PDF]
Molecules, 2020 Chitosan nanoparticles have gained attention as drug delivery systems (DDS) in the medical field as they are both biodegradable and biocompatible with reported antimicrobial and anti-leishmanial activities.
Alaa Riezk +4 more
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Immunomodulation From Moderate Exercise Promotes Control of Experimental Cutaneous Leishmaniasis [PDF]
Frontiers in Cellular and Infection Microbiology, 2019 Physical exercise has been described as an important tool in the prevention and treatment of numerous diseases as it promotes a range of responses and adaptations in several biological systems, including the immune system.
Rodrigo Terra +7 more
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Peptide-Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives. [PDF]
ChemMedChemPeptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Carnero Canales CS +7 more
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Murine T Cell-Dependent Response Affects Leishmania amazonensis Amastigote Survival and Virulence. [PDF]
Cell Biol IntABSTRACT Our group has previously described the infection course of Leishmania amazonensis in BALB/c and BALB/cnu/nu mice, which have distinct T‐cell dependent responses. In this study, lesion‐derived amastigotes exhibited differential protein expression in a host‐dependent manner.
Soares GHC, Barbosa GR, Stolf BS.
europepmc +2 more sources
Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2019 Katrien Van Bocxlaer +2 more
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Microemulsion based on methyl 3,4,5-trihydroxybenzoate for the topical treatment of cutaneous leishmaniasis: an in vivo assay [PDF]
Acta Amazonica, 2023 Cutaneous leishmaniasis, caused by protozoa of the genus Leishmania, presents diverse clinical manifestations, and current therapeutic options have limitations, including long treatment periods, potential hospitalization, and excessive pain during ...
Thiago de Jesus BACHA +8 more
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Materials & Design, 2021 Leishmaniasis is a tropical disease caused by parasites of the genus Leishmania spp; it presents different clinical manifestations, of which cutaneous leishmaniasis is the most common form, and it is endemic in more than 70 countries worldwide. Only four
Jorge Higuita-Castro +6 more
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International Journal for Parasitology: Drugs and Drug Resistance, 2020 Paromomycin is an aminoglycoside antibiotic approved in 2006 for the treatment of visceral leishmaniasis caused by Leishmania donovani in Southeast Asia.
Elizabeth M. Coser +5 more
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A Luciferase-Expressing Leishmania braziliensis Line That Leads to Sustained Skin Lesions in BALB/c Mice and Allows Monitoring of Miltefosine Treatment Outcome. [PDF]
PLoS Neglected Tropical Diseases, 2016 Leishmania braziliensis is the most prevalent species isolated from patients displaying cutaneous and muco-cutaneous leishmaniasis in South America. However, there are difficulties for studying L.
Adriano C Coelho +5 more
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