Results 31 to 40 of about 7,418 (172)

MILTEFOSINE IN TREATMENT OF OLD WORLD CUTANEOUS LEISHMANIASIS IN PAKISTAN

Pakistan Armed Forces Medical Journal, 2010
Objective: To evaluate the efficacy of miltefosine in the treatment of cutaneous leishmaniasis Study Design: Uncontrolled, open label, quasi-experimental study Place and Duration of Study: The study was carried out in Military Hospital Rawalpindi and ...
Brig Nasser Rashid Dar, Simeen Ber Rehman, Muhammad Abbas, Muhammad Amjad, Asher Ahmed Mashhood, Qamar ., Khalid Ranjha, Sibghat Ullah Rao   +7 more
doaj   +2 more sources

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Exposure of phosphatidylserine on Leishmania amazonensis isolates is associated with diffuse cutaneous leishmaniasis and parasite infectivity. [PDF]

PLoS ONE, 2012
Diffuse cutaneous leishmaniasis (DCL) is a rare clinical manifestation of leishmaniasis, characterized by an inefficient parasite-specific cellular response and heavily parasitized macrophages.
Jaqueline França-Costa, João Luiz Mendes Wanderley, Poliana Deolindo, Jessica B Zarattini, Jackson Costa, Lynn Soong, Marcello André Barcinski, Aldina Barral, Valeria M Borges   +8 more
doaj   +1 more source

Symmetrical Lupoid Onychodystrophy in Review: Lessons Learned From 31 Cases

Veterinary Dermatology, EarlyView.
Background: Symmetrical lupoid onychodystrophy (SLO) is a complex disease that exclusively affects the claws of dogs and represents a therapeutic challenge. Biopsy sampling of the third phalanx for histopathological evaluation has historically been the recommended diagnostic test, yet clinical diagnosis is currently encouraged.
Jessica R. Calesso, Clarissa P. Souza, Stephanie R. Bruner, Adriane P. C. V. Bicalho   +3 more
wiley   +1 more source

Antileishmanial activity of extracts from Libidibia ferrea: development of in vitro and in vivo tests [PDF]

Acta Amazonica, 2017
Treatment of cutaneous leishmaniasis (CL) is difficult due to the scarce number of drugs able to eliminate completely the intracellular form of the parasite.
Claudia Dantas COMANDOLLI-WYREPKOWSKI, Bruno Bezerra JENSEN, Iryna GRAFOVA, Pierre Alexandre dos SANTOS, Angela Maria Comapa BARROS, Fabiane Veloso SOARES, José Fernando Marques BARCELLOS, Aline Fagundes da SILVA, Andriy GRAFOV, Antonia Maria Ramos FRANCO   +9 more
doaj   +2 more sources

HetCA/STOCSY‐Guided Dereplication of Artemisia arborescens Reveals Furofuran Lignans with Antileishmanial Effects

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Bioactive metabolites can remain hidden in negligible activity extracts. A statistical spectroscopy–driven dereplication workflow integrating the HeteroCovariance Approach (HetCA) and Statistical Total Correlation Spectroscopy (STOCSY) prioritized furofuran lignans in Artemisia arborescens, identifying three compounds with moderate antileishmanial ...
Olga Karoutzou, Stavros Beteinakis, Olga Koutsoni, Despina Smirlis, Maria Halabalaki, Leandros Alexios Skaltsounis, Emmanuel Mikros   +6 more
wiley   +1 more source

The Effect of Designed Home Visit Program on Promoting Cutaneous Leishmaniasis Preventive Behaviors

نشریه پرستاری ایران, 2007
Introduction & Aim: Cutaneous Leishmaniasis is the second common parasitic disease in Iran. According to several studies, insufficient knowledge of mothers about the prevention strategies related to occurrence of the disease in their children are ...
A. Hossein nejad Nayrisi, F. Alhani, M. Anoosheh, S. Faghihzadeh   +3 more
doaj  

Study of the Effectiveness of Drugs for the Treatment of Zoonotic Cutaneous Leishmaniasis in vivo on a Laboratory Model

Антибиотики и Химиотерапия, 2020
Confirmed evidence of sufficient effectiveness of monotherapy of zoonotic cutaneous leishmaniasis with meglumine antimonate and doxycycline in combination with interferon alpha 2b human recombinant (reaferon) has been obtained.
Yu. K. Kuznetsova
doaj  

Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species

Journal of Immunology Research, 2019
Worldwide, an estimated 12 million people are infected with Leishmania spp. and an additional 350 million are at risk of infection. Leishmania are intracellular parasites that cause disease by suppressing macrophage microbicidal responses.
Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodríguez   +2 more
doaj   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source