Results 21 to 30 of about 7,418 (172)

Treatment of leishmaniasis with chemotherapy and vaccine: a mathematical model

Journal of Biological Dynamics, 2023
Leishmaniasis, an infectious disease, manifests itself mostly in two forms, cutaneous leishmaniasis (CL) and, a more severe and potentially deadly form, visceral leishmaniasis (VL).
Nourridine Siewe, Avner Friedman
doaj   +1 more source

Healed Lesions of Human Cutaneous Leishmaniasis Caused By Leishmania major Do Not Shelter Persistent Residual Parasites

Frontiers in Cellular and Infection Microbiology, 2022
In human cutaneous leishmaniasis (HCL) caused by Leishmania (L.) major, the cutaneous lesions heal spontaneously and induce a Th1-type immunity that confers solid protection against reinfection.
Rabiaa M. Sghaier, Rabiaa M. Sghaier, Fouad Benhnini, Fouad Benhnini, Fatma Z. Guerfali, Fatma Z. Guerfali, Hanène Attia, Hanène Attia, Aymen Bali, Aymen Bali, Amor Zaatour, Amor Zaatour, Amor Zaatour, Ghada Mkannez, Ghada Mkannez, Adel Gharbi, Adel Gharbi, Adel Gharbi, Nabil Belhaj-Hamida, Nabil Belhaj-Hamida, Nabil Belhaj-Hamida, Hichem Dridi, Hichem Dridi, Hichem Dridi, Afif Ben-Salah, Afif Ben-Salah, Afif Ben-Salah, Afif Ben-Salah, Koussay Dellagi, Koussay Dellagi, Dhafer Laouini, Dhafer Laouini   +31 more
doaj   +1 more source

Protective Immunity and Vaccination Against Cutaneous Leishmaniasis

Frontiers in Immunology, 2012
Although a great deal of knowledge has been gained from studies on the immunobiology of leishmaniasis, there is still no effective vaccine against the disease.
Ifeoma eOkwor, Zhirong eMou, Liu eDong, JUDE EZEH UZONNA, JUDE EZEH UZONNA   +4 more
doaj   +1 more source

Chemotherapeutic potential of 17-AAG against cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: Leishmaniasis remains a worldwide public health problem. The limited therapeutic options, drug toxicity and reports of resistance, reinforce the need for the development of new treatment options.
Diego M Santos, Antonio L O A Petersen, Fabiana S Celes, Valeria M Borges, Patricia S T Veras, Camila I de Oliveira   +5 more
doaj   +1 more source

Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis [PDF]

Antimicrobial Agents and Chemotherapy, 1997
The polyene antibiotic amphotericin B is currently a second-line treatment for visceral leishmaniasis (VL) and mucocutaneous leishmaniasis. Lipid-amphotericin B formulations with lower toxicity than the parent drug that were developed for the treatment of systemic mycoses have proved to be an effective treatment for VL, especially AmBisome, a small ...
V, Yardley, S L, Croft
openaire   +2 more sources

Differential Susceptibility to Antimony in Strains and Clinical Isolates of Leishmania amazonensis from Brazil: In Vitro and In Vivo Studies and Implications for Drug Response and Treatment Failure

Pathogens
In Brazil, cutaneous leishmaniasis is endemic and may be caused by Leishmania amazonensis. This species is the second most prevalent species in that country, and it is responsible for localized cutaneous and diffuse cutaneous leishmaniasis.
Victor de Sousa Agostino, Leonardo F. Geres, Stéphane de la Roca, Beatriz T. de Moraes, Juliana I. Aoki, Elizabeth M. Coser, Nilson Branco, Adriano C. Coelho   +7 more
doaj   +1 more source

Treatment of experimental cutaneous leishmaniasis with liposome-intercalated amphotericin B [PDF]

Antimicrobial Agents and Chemotherapy, 1984
The therapeutic efficacy of a liposomal preparation of amphotericin B was evaluated in two murine models of cutaneous leishmaniasis. No significant decrease in tissue parasite density was observed in C57BL/6 mice after systemic treatment instituted seven days after footpad inoculation with Leishmania tropica; in contrast, BALB/c mice showed a modest ...
C B, Panosian, M, Barza, F, Szoka, D J, Wyler   +3 more
openaire   +2 more sources

The Effectiveness of Perovskia abrotanoides Extract Topical Formulation on the Cutaneous Leishmaniasis: A Randomized Controlled Clinical Trial

Journal of Research in Pharmacy Practice
Objective: Despite many attempts to treat leishmaniasis, new approaches are necessary to reduce the burden of disease. Perovskia abrotanoides (Brazambel) has shown significant effects against Leishmania parasites in some studies.
Maryam Sadat Tayebi, Nazila Poostiyan, Masoud Sadeghi Dinani, Erfaneh Ghassami, Rasool Soltani   +4 more
doaj   +1 more source

Artificial Intelligence in Dermatology: Current Applications and Future Directions

JEADV Clinical Practice, EarlyView.
This scoping review of 56 studies maps AI applications in dermatology. Image‐based classification for skin cancer detection dominates (48%), followed by clinical decision support (21%), teledermatology triage (11%), and predictive analytics (11%). While deep learning algorithms demonstrate diagnostic performance comparable to clinicians in controlled ...
Sofía Pérez‐Lalinde, Francisco Flores   +1 more
wiley   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source