Efficacy of oleylphosphocholine in experimental cutaneous leishmaniasis. [PDF]
J Antimicrob Chemother, 2023 Abstract Objectives Cutaneous leishmaniasis (CL) is a neglected tropical disease causing a range of skin lesions for which safe and efficacious drugs are lacking. Oleylphosphocholine (OLPC) is structurally similar to miltefosine and has previously demonstrated potent activity against visceral ...
Van Bocxlaer K +8 more
europepmc +4 more sources
INFLUENCE OF MICROBIOTA IN EXPERIMENTAL CUTANEOUS LEISHMANIASIS IN SWISS MICE [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 1999 Infection of Swiss/NIH mice with Leishmania major was compared with infection in isogenic resistant C57BL/6 and susceptible BALB/c mice. Swiss/NIH mice showed self-controlled lesions in the injected foot pad. The production of high levels of interferon-g
OLIVEIRA Marcia Rosa de +5 more
doaj +4 more sources
CD4+ T cell subsets in experimental cutaneous leishmaniasis [PDF]
Memorias do Instituto Oswaldo Cruz, 1988 Phillip Scott +4 more
doaj +4 more sources
Efficacy of Paromomycin-Chloroquine Combination Therapy in Experimental Cutaneous Leishmaniasis. [PDF]
Antimicrob Agents Chemother, 2017 ABSTRACT The 4-aminoquinoline chloroquine (CQ) is clinically used in combination with doxycycline to cure chronic Q fever, as it enhances the activity of the antibiotic against the causative bacterium Coxiella burnetii residing within macrophage phagolysosomes.
Wijnant GJ +4 more
europepmc +5 more sources
Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine [PDF]
Acta Amazonica, 2017 Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration.
Claudia Dantas COMANDOLLI-WYREPKOWSKI +6 more
doaj +2 more sources
Ursolic Acid Potentializes Conventional Therapy in Experimental Leishmaniasis
Pathogens, 2020 Ursolic acid (UA) is a triterpene with a broad array of pharmacological activities. In leishmaniasis, UA killed different species of parasites, and it was active in the experimental model of cutaneous and visceral leishmaniasis.
Jéssica Adriana Jesus +5 more
doaj +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 2013 SUMMARY The clinical outcome of infection with Leishmania species of the subgenus Viannia in hamster model (Mesocricetus auratus) has shown to be different depending on experimental protocol.
Angela Maria Gomez-Galindo +1 more
doaj +1 more source
Radical Cure of Experimental Cutaneous Leishmaniasis by the Bisphosphonate Pamidronate [PDF]
The Journal of Infectious Diseases, 2002 The effects in vivo of the bisphosphonate drug pamidronate, used in bone resorption therapy, were investigated in an experimental model of cutaneous leishmaniasis. Pamidronate at an intraperitoneal dose of 10 mg/kg/day for 5 days effects a radical cure of cutaneous leishmaniasis in Balb/c mice, as evidenced by long-term disappearance of lesions ...
Noris, Rodriguez +5 more
openaire +2 more sources
Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia.
PLoS Neglected Tropical Diseases, 2012 BackgroundCutaneous leishmaniasis is a vector-borne disease that is in Ethiopia mainly caused by the parasite Leishmania aethiopica. This neglected tropical disease is common in rural areas and causes serious morbidity.
Tamrat Abebe +13 more
doaj +1 more source
Combination therapy with tamoxifen and amphotericin B in experimental cutaneous leishmaniasis. [PDF]
Antimicrob Agents Chemother, 2014 ABSTRACTLeishmaniasis chemotherapy remains very challenging. The high cost of active drugs, along with the severity of their side effects and the increasing failure rate of the current therapeutic schemes, calls for the discovery of new active drugs and schemes of treatment.
Trinconi CT +4 more
europepmc +4 more sources