Results 41 to 50 of about 7,418 (172)

Effect of educational intervention based on the PRECEDE-PROCEED model on preventive behaviors of cutaneous leishmaniasis among housewives

Cadernos de Saúde Pública
Leishmaniasis is an endemic disease in Iran. Since education to prevent the disease is important, this study aimed to determine the effect of educational intervention based on the PRECEDE-PROCEED model on preventive behaviors of cutaneous leishmaniosis ...
Ali Khani Jeihooni, Pooyan Afzali Harsini, Seyyed Mansour Kashfi, Tayebe Rakhshani   +3 more
doaj   +1 more source

Sitamaquine as a putative antileishmanial drug candidate: from the mechanism of action to the risk of drug resistance

Parasite, 2011
Sitamaquine is a 8-aminoquinoline in development for the treatment of visceral leishmaniasis by oral route, no activity being observed on the experimental cutaneous leishmaniasis experimental models.
Loiseau P.M., Cojean S., Schrével J.
doaj   +1 more source

Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis

npj Vaccines, 2022
Leishmaniasis is a neglected protozoan disease affecting over 12 million people globally with no approved vaccines for human use. New World cutaneous leishmaniasis (CL) caused by L. mexicana is characterized by the development of chronic non-healing skin
Greta Volpedo, Thalia Pacheco-Fernandez, Erin A. Holcomb, Wen-Wei Zhang, Patrick Lypaczewski, Blake Cox, Rebecca Fultz, Chelsea Mishan, Chaitenya Verma, Ryan H. Huston, Abigail R. Wharton, Ranadhir Dey, Subir Karmakar, Steve Oghumu, Shinjiro Hamano, Sreenivas Gannavaram, Hira L. Nakhasi, Greg Matlashewski, Abhay R. Satoskar   +18 more
doaj   +1 more source

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas, Eduardo Oliveira S. da Silva, Daniela C. Tristão, Guilherme M. Antar, Daniela P. Lage, Dóris M. Abrão, Luciana M. Ribeiro Antinarelli, Elaine S. Coimbra, João Henrique G. Lago, Eduardo A. F. Coelho   +9 more
wiley   +1 more source

Immunotherapy and immunochemotherapy in visceral leishmaniasis: promising treatments for this neglected disease

Frontiers in Immunology, 2014
Leishmaniasis has several clinical forms: self-healing or chronic cutaneous leishmaniasis or post-kala-azar dermal leishmaniasis; mucosal leishmaniasis; and visceral leishmaniasis, which is fatal if left untreated.
Bruno Mendes Roatt, Bruno Mendes Roatt, Bruno Mendes Roatt, Rodrigo D.O. Aguiar-Soares, Rodrigo D.O. Aguiar-Soares, Wendel eCoura-Vital, Henrique G. Ker, Nádia das Dores Moreira, Juliana eVitoriano-Souza, Rodolfo Cordeiro Giunchetti, Rodolfo Cordeiro Giunchetti, Cláudia Martins Carneiro, Alexandre Barbosa Reis, Alexandre Barbosa Reis, Alexandre Barbosa Reis   +14 more
doaj   +1 more source

Further Evidence of an Association between the Presence of Leishmania RNA Virus 1 and the Mucosal Manifestations in Tegumentary Leishmaniasis Patients. [PDF]

PLoS Neglected Tropical Diseases, 2015
Tegumentary Leishmaniasis (TL) is endemic in Latin America, and Brazil contributes approximately 20 thousand cases per year. The pathogenesis of TL, however, is still not fully understood. Clinical manifestations vary from cutaneous leishmaniasis (CL) to
Lilian Motta Cantanhêde, Cipriano Ferreira da Silva Júnior, Marcos Massayuki Ito, Kátia Paula Felipin, Roberto Nicolete, Juan Miguel Villalobos Salcedo, Renato Porrozzi, Elisa Cupolillo, Ricardo de Godoi Mattos Ferreira   +8 more
doaj   +1 more source

Murine T Cell‐Dependent Response Affects Leishmania amazonensis Amastigote Survival and Virulence

Cell Biology International, Volume 50, Issue 8, August 2026.
ABSTRACT Our group has previously described the infection course of Leishmania amazonensis in BALB/c and BALB/cnu/nu mice, which have distinct T‐cell dependent responses. In this study, lesion‐derived amastigotes exhibited differential protein expression in a host‐dependent manner.
Gustavo Henrique Corrêa Soares, Gustavo Rolim Barbosa, Beatriz Simonsen Stolf   +2 more
wiley   +1 more source

Formulation of Amphotericin B in PEGylated Liposomes for Improved Treatment of Cutaneous Leishmaniasis by Parenteral and Oral Routes

Pharmaceutics, 2022
Liposomal amphotericin B (AmB) or AmBisome® is the most effective and safe therapeutic agent for visceral leishmaniasis (VL), but its clinical efficacy is limited in cutaneous leishmaniasis (CL) and HIV/VL co-infection.
Guilherme S. Ramos, Virgínia M. R. Vallejos, Gabriel S. M. Borges, Raquel M. Almeida, Izabela M. Alves, Marta M. G. Aguiar, Christian Fernandes, Pedro P. G. Guimarães, Ricardo T. Fujiwara, Philippe M. Loiseau, Lucas A. M. Ferreira, Frédéric Frézard   +11 more
doaj   +1 more source

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Effects of qinghaosu (artemisinin) and its derivatives on experimental cutaneous leishmaniasis

Parasitology, 1993
SUMMARYWe have investigated the effect of qinghaosu (QHS, artemisinin) and its derivatives onLeishmania majorreplicationin vitroand on the disease development in mice infected withL. major. Artemisinin is effective against promastigotesin vitro, with an ED50(50% effective dose) at 7.5 × 10−7m.
D M, Yang, F Y, Liew
openaire   +2 more sources