Results 41 to 50 of about 8,397 (218)

Efficacy of Thermotherapy to Treat Cutaneous Leishmaniasis Caused by Leishmania tropica in Kabul, Afghanistan: A Randomized, Controlled Trial [PDF]

, 2005
BACKGROUND: Pentavalent antimony is the agent recommended for treatment of cutaneous leishmaniasis (CL). Its use is problematic, because it is expensive and because of the potential for drug-associated adverse effects during a lengthy and painful ...
Davies, C.R., Reithinger, R, Quinnell, RJ, Quinnell, R.J., Bismullah, M, Davies, CR, David, J.R., Reithinger, R., Mohsen, M., Wahid, M., Bismullah, M., Wahid, M, David, JR, Kolaczinski, J., Kolaczinski, J, Mohsen, M   +15 more
core   +1 more source

Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis [PDF]

Antimicrobial Agents and Chemotherapy, 1997
The polyene antibiotic amphotericin B is currently a second-line treatment for visceral leishmaniasis (VL) and mucocutaneous leishmaniasis. Lipid-amphotericin B formulations with lower toxicity than the parent drug that were developed for the treatment of systemic mycoses have proved to be an effective treatment for VL, especially AmBisome, a small ...
V, Yardley, S L, Croft
openaire   +2 more sources

Differential Susceptibility to Antimony in Strains and Clinical Isolates of Leishmania amazonensis from Brazil: In Vitro and In Vivo Studies and Implications for Drug Response and Treatment Failure

Pathogens
In Brazil, cutaneous leishmaniasis is endemic and may be caused by Leishmania amazonensis. This species is the second most prevalent species in that country, and it is responsible for localized cutaneous and diffuse cutaneous leishmaniasis.
Victor de Sousa Agostino, Leonardo F. Geres, Stéphane de la Roca, Beatriz T. de Moraes, Juliana I. Aoki, Elizabeth M. Coser, Nilson Branco, Adriano C. Coelho   +7 more
doaj   +1 more source

Treatment of experimental cutaneous leishmaniasis with liposome-intercalated amphotericin B [PDF]

Antimicrobial Agents and Chemotherapy, 1984
The therapeutic efficacy of a liposomal preparation of amphotericin B was evaluated in two murine models of cutaneous leishmaniasis. No significant decrease in tissue parasite density was observed in C57BL/6 mice after systemic treatment instituted seven days after footpad inoculation with Leishmania tropica; in contrast, BALB/c mice showed a modest ...
C B, Panosian, M, Barza, F, Szoka, D J, Wyler   +3 more
openaire   +2 more sources

Structures, targets and recent approaches in anti-leishmanial drug discovery and development. [PDF]

, 2011
Recent years have seen a significant improvement in available treatment options for leishmaniasis. Two new drugs, miltefosine and paromomycin, have been registered for the treatment of visceral leishmaniasis (VL) in India since 2002.
Karin Seifert, Seifert, Karin
core   +1 more source

The Effectiveness of Perovskia abrotanoides Extract Topical Formulation on the Cutaneous Leishmaniasis: A Randomized Controlled Clinical Trial

Journal of Research in Pharmacy Practice
Objective: Despite many attempts to treat leishmaniasis, new approaches are necessary to reduce the burden of disease. Perovskia abrotanoides (Brazambel) has shown significant effects against Leishmania parasites in some studies.
Maryam Sadat Tayebi, Nazila Poostiyan, Masoud Sadeghi Dinani, Erfaneh Ghassami, Rasool Soltani   +4 more
doaj   +1 more source

Exposure of phosphatidylserine on Leishmania amazonensis isolates is associated with diffuse cutaneous leishmaniasis and parasite infectivity. [PDF]

PLoS ONE, 2012
Diffuse cutaneous leishmaniasis (DCL) is a rare clinical manifestation of leishmaniasis, characterized by an inefficient parasite-specific cellular response and heavily parasitized macrophages.
Jaqueline França-Costa, João Luiz Mendes Wanderley, Poliana Deolindo, Jessica B Zarattini, Jackson Costa, Lynn Soong, Marcello André Barcinski, Aldina Barral, Valeria M Borges   +8 more
doaj   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source

Two Leishmania species circulating in the Kaleybar focus of infantile visceral leishmaniasis, northwest Iran: implications for deltamethrin dog collar intervention [PDF]

, 2008
Leishmania infantum is the causative agent of infantile visceral leishmaniasis (IVL) in the Mediterranean Basin and, based on isoenzyme typing of a few isolates from patients and domestic dogs, this parasite was considered to predominate in the Kaleybar ...
Ready, P. D. (Paul Donald), Parvizi, P, Mazloumi-Gavgani, A. S., Davies, CR, Ready, PD, Courtenay, Orin, P.D. Ready, P. Parvizi, A.S. Mazloumi-Gavgani, C.R. Davies, Parvizi, P., Courtenay, O, O. Courtenay, Mazloumi-Gavgani, AS, Davies, C. R.   +14 more
core   +1 more source

Antileishmanial activity of extracts from Libidibia ferrea: development of in vitro and in vivo tests [PDF]

Acta Amazonica, 2017
Treatment of cutaneous leishmaniasis (CL) is difficult due to the scarce number of drugs able to eliminate completely the intracellular form of the parasite.
Claudia Dantas COMANDOLLI-WYREPKOWSKI, Bruno Bezerra JENSEN, Iryna GRAFOVA, Pierre Alexandre dos SANTOS, Angela Maria Comapa BARROS, Fabiane Veloso SOARES, José Fernando Marques BARCELLOS, Aline Fagundes da SILVA, Andriy GRAFOV, Antonia Maria Ramos FRANCO   +9 more
doaj   +2 more sources