Results 71 to 80 of about 434,787 (260)

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Effects of Caffeine and Lycopene in Experimentally Induced Diabetes Mellitus

Pancreas, 2016
Diabetes mellitus (DM) is a global epidemic with increasing prevalence. The disease is chronic in nature, and patients must use antidiabetic drugs or insulin during their lifespan. Because of the difficulty of using injectable insulin preparations, patients and practitioners prefer to use oral antidiabetic drugs for prophylaxis and treatment. There are,
Ozmen, O., Topsakal, Şenay, Haligur, M., Aydogan, A., Dincoglu, D.   +4 more
openaire   +4 more sources

The latest progression of N6-methyladenosine (m6A) RNA modification in diabetes mellitus and diabetic complications

Frontiers in Endocrinology
The increasing global prevalence of diabetes mellitus and its complications continues to encourage exploration of novel molecular mechanisms for their prevention and treatment.
Guangyang Yin, Jiajing Hong, Guohui Shan, Cuizhu Xu, Bailin Li, Dongyu Yang   +5 more
doaj   +1 more source

Remodeling of adipose tissue at experimental diabetes mellitus

Zaporožskij Medicinskij Žurnal, 2013
Introduction Diabetes mellitus (DM) type 1 is chronіc disease whith progressive selective destruction of β- cells pancreatic islets (of Langerhans) and whith development of absolute insulin failure.
O. A. Konovalova, A. M. Kamyshnyi
doaj   +1 more source

β-Cell Autophagy Pathway and Endoplasmic Reticulum Stress Regulating-Role of Liposomal Curcumin in Experimental Diabetes Mellitus: A Molecular and Morphometric Study. [PDF]

Antioxidants (Basel), 2022
Khater SI, Dowidar MF, Abdel-Aziz AE, Khamis T, Dahran N, Alqahtani LS, Metwally MMM, Al-Hady Abd-Elrahamn AS, Alsieni M, Alosaimi ME, Abduljabbar MH, Mohamed AA.   +11 more
europepmc   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Effect of extracts of Geranium ayavacense W. (Pasuchaca) on glycemia on rats with experimental diabetes mellitus

Revista Peruana de Medicina Experimental y Salud Pública, 2014
Objectives. To determine if the lyophilized aqueous extract of Geranium ayavacense (Pasuchaca) has any effect on glycemia in rats with experimental diabetes mellitus. Materials and methods. Experimental diabetes was induced with alloxan. Rats included in
José Aranda-Ventura, Jorge Villacrés, Rosario Mego, Henry Delgado   +3 more
doaj   +1 more source

Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect. [PDF]

Antioxidants (Basel), 2021
Rodríguez-Pérez MD, López-Villodres JA, Arrebola MM, Martín-Aurioles E, Fernández-Prior Á, Bermúdez-Oria A, Ríos MC, De La Cruz JP, González-Correa JA.   +8 more
europepmc   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

Streptozotocin model of stable diabetes mellitus

Вестник трансплантологии и искусственных органов, 2019
Aim: to create a model of stable experimental diabetes mellitus (DM) in laboratory rats using streptozotocin (STZ).Materials and methods. The dynamics of changes in glycemia and survival in 60 Wistar rats was determined.
G. N. Skaletskaya, N. N. Skaletskiy, E. A. Volkova, V. I. Sevastyanov   +3 more
doaj   +1 more source