Results 1 to 10 of about 1,042,213 (319)

Toll-like Receptors in Viral Encephalitis

Viruses, 2021
Viral encephalitis is a rare but serious syndrome. In addition to DNA-encoded herpes viruses, such as herpes simplex virus and varicella zoster virus, RNA-encoded viruses from the families of Flaviviridae, Rhabdoviridae and Paramyxoviridae are important ...
Olivia Luise Gern, Felix Mulenge, Andreas Pavlou, Luca Ghita, Imke Steffen, Martin Stangel, Ulrich Kalinke   +6 more
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Autophagy-enhancing drugs limit mucosal HIV-1 acquisition and suppress viral replication ex vivo

Scientific Reports, 2021
Current direct-acting antiviral therapies are highly effective in suppressing HIV-1 replication. However, mucosal inflammation undermines prophylactic treatment efficacy, and HIV-1 persists in long-lived tissue-derived dendritic cells (DCs) and CD4+ T ...
Alexandra P. M. Cloherty, Nienke H. van Teijlingen, Tracy-Jane T. H. D. Eisden, John L. van Hamme, Anusca G. Rader, Teunis B. H. Geijtenbeek, Renée R. C. E. Schreurs, Carla M. S. Ribeiro   +7 more
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The thymic microenvironment gradually modulates the phenotype of thymus‐homing peripheral conventional dendritic cells

Immunity, Inflammation and Disease, 2022
Background & Aims Thymic conventional dendritic cells (t‑DCs) are crucial for the development of T cells. A substantial fraction of t‑DCs originates extrathymically and migrates to the thymus.
Susanne Herppich, Michael Beckstette, Jochen Huehn   +2 more
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Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human Hepatocytes

Cells, 2021
The liver is targeted by several human pathogenic RNA viruses for viral replication and dissemination; despite this, the extent of innate immune sensing of RNA viruses by human hepatocytes is insufficiently understood to date.
Wiebke Nicolay, Rebecca Moeller, Sina Kahl, Florian W. R. Vondran, Thomas Pietschmann, Stefan Kunz, Gisa Gerold   +6 more
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Signatures of V H 1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins

Nature Communications, 2023
An effective preventive vaccine for hepatitis C virus (HCV) remains a major unmet need. Antigenic region 3 (AR3) on the E1E2 envelope glycoprotein complex overlaps with the CD81 receptor binding site and represents an important epitope for broadly ...
Joan Capella-Pujol, Marlon de Gast, Laura Radić, Ian Zon, Ana Chumbe, Sylvie Koekkoek, Wouter Olijhoek, Janke Schinkel, Marit J. van Gils, Rogier W. Sanders, Kwinten Sliepen   +10 more
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Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate

Metabolites, 2021
Itaconate is derived from the tricarboxylic acid (TCA) cycle intermediate cis-aconitate and links innate immunity and metabolism. Its synthesis is altered in inflammation-related disorders and it therefore has potential as clinical biomarker.
Moritz Winterhoff, Fangfang Chen, Nishika Sahini, Thomas Ebensen, Maike Kuhn, Volkhard Kaever, Heike Bähre, Frank Pessler   +7 more
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STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

Nature Communications, 2019
Innate immune signaling pathways sense different microbial features and can elicit distinct yet overlapping immune responses. Here the authors dissect the contribution of these pathways to the response to MCMV infection and find that STING signaling is ...
Pia-Katharina Tegtmeyer, Julia Spanier, Katharina Borst, Jennifer Becker, André Riedl, Christoph Hirche, Luca Ghita, Jennifer Skerra, Kira Baumann, Stefan Lienenklaus, Marius Doering, Zsolt Ruzsics, Ulrich Kalinke   +12 more
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Motivations for (non)participation in population-based health studies among the elderly – comparison of participants and nonparticipants of a prospective study on influenza vaccination

BMC Medical Research Methodology, 2017
Background Participation in epidemiological studies has strongly declined in recent years. We examined the reasons for (non)participation in population-based health studies among participants and nonparticipants of a prospective study on influenza ...
Manas K. Akmatov, Leonhard Jentsch, Peggy Riese, Marcus May, Malik W. Ahmed, Damaris Werner, Anja Rösel, Jana Prokein, Inga Bernemann, Norman Klopp, Blair Prochnow, Thomas Illig, Christoph Schindler, Carlos A. Guzman, Frank Pessler   +14 more
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Transmission of anelloviruses to HIV-1 infected children

Frontiers in Microbiology, 2022
Anelloviruses (AVs) are widespread in the population and infect humans at the early stage of life. The mode of transmission of AVs is still unknown, however, mother-to-child transmission, e.g., via breastfeeding, is one of the likely infection routes. To
Joanna Kaczorowska, Joanna Kaczorowska, Aurelija Cicilionytė, Aurelija Cicilionytė, Annet Firouzi Wahdaty, Annet Firouzi Wahdaty, Martin Deijs, Martin Deijs, Maarten F. Jebbink, Maarten F. Jebbink, Margreet Bakker, Margreet Bakker, Lia van der Hoek, Lia van der Hoek   +13 more
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Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population

Human Vaccines & Immunotherapeutics, 2017
Elderly individuals have the highest burden of disease from influenza infection but also the lowest immune response to influenza vaccination. A better understanding of the host response to influenza vaccination in the elderly is therefore urgently needed.
Manas K. Akmatov, Peggy Riese, Marcus May, Leonhard Jentsch, Malik W. Ahmed, Damaris Werner, Anja Rösel, Megan Tyler, Kevin Pessler, Jana Prokein, Inga Bernemann, Norman Klopp, Blair Prochnow, Stephanie Trittel, Aravind Tallam, Thomas Illig, Christoph Schindler, Carlos A. Guzmán, Frank Pessler   +18 more
doaj   +1 more source