Results 41 to 50 of about 1,042,213 (319)

Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease

Journal of Neuroinflammation, 2020
Background The type 1 interferon (IFN) response is part of the innate immune response and best known for its role in viral and bacterial infection. However, this pathway is also induced in sterile inflammation such as that which occurs in a number of ...
Ayelet Vardi, Shifra Ben-Dor, Soo Min Cho, Ulrich Kalinke, Julia Spanier, Anthony H. Futerman   +5 more
doaj   +1 more source

EXPERIMENTAL STUDIES ON PNEUMOCOCCUS INFECTIONS [PDF]

Journal of Experimental Medicine, 1909
1. Phagocytosis of pneumococci in vitro runs parallel with phagocytosis in vivo. 2. Virulence depends not only on resistance to phagocytosis, but also on the ability to grow in the body of the animal. 3. The biological reaction of the pigeon to pneumococcus infection does not differ from that of the mouse. 4.
openaire   +2 more sources

Experimental treatment of Curvularia infection

Diagnostic Microbiology and Infectious Disease, 2014
We have evaluated the efficacy of amphotericin B, posaconazole, and voriconazole in immunosuppressed murine models of disseminated infection by Curvularia spicifera and Curvularia hawaiiensis. The 3 antifungals improved survival of mice in comparison to controls; however, only the 2 azoles were able to reduce significantly the fungal load.
Paredes, K., Capilla, J., Sutton, D.A., Mayayo, E., Fothergill, A.W., Guarro, J.   +5 more
openaire   +3 more sources

Changes in microbiota during experimental human Rhinovirus infection

, 2015
Human Rhinovirus (HRV) is responsible for the majority of common colds and is frequently accompanied by secondary bacterial infections through poorly understood mechanisms.
Hofstra, J. J., Lutter, R., de Jong, M. D., van de Pol, M. A., van der Hoek, L., de Wever, B., P. J. Sterk, R. Molenkamp, R. Lutter, Deijs, M., K. C. Wolthers, S. Matamoros, M. A. van de Pol, B. de Wever, Sterk, P. J., J. J. Hofstra, H. Wendt-Knol, M. W. Tanck, L. van der Hoek, M. D. de Jong, Tanck, M. W., Matamoros, S., C. E. Visser, Wolthers, K. C., M. Deijs, Wendt-Knol, H., Molenkamp, R., Visser, C. E.   +27 more
core   +1 more source

Transcriptomic analysis unveils bona fide molecular signatures of microglia under conditions of homeostasis and viral encephalitis

Journal of Neuroinflammation
Microglia serve as a front-line defense against neuroinvasive viral infection, however, determination of their actual transcriptional profiles under conditions of health and disease is challenging.
Felix Mulenge, Olivia Luise Gern, Lena Mareike Busker, Angela Aringo, Luca Ghita, Inken Waltl, Andreas Pavlou, Ulrich Kalinke   +7 more
doaj   +1 more source

Natural reservoirs for homologs of hepatitis C virus

Emerging Microbes and Infections, 2014
Hepatitis C virus is considered a major public health problem, infecting 2%–3% of the human population. Hepatitis C virus infection causes acute and chronic liver disease, including chronic hepatitis, cirrhosis and hepatocellular carcinoma.
Stephanie Pfaender, Richard JP Brown, Thomas Pietschmann, Eike Steinmann   +3 more
doaj   +1 more source

Role of serotype and virulence determinants of Streptococcus pyogenes biofilm bacteria in internalization and persistence in epithelial cells in vitro

Frontiers in Cellular and Infection Microbiology, 2023
Streptococcus pyogenes causes a multitude of local and systemic infections, the most common being pharyngitis in children. Recurrent pharyngeal infections are common and are thought to be due to the re-emergence of intracellular GAS upon completion of ...
Feiruz Alamiri, Oscar André, Supradipta De, Pontus Nordenfelt, Anders P. Hakansson   +4 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Statistical analysis of "Plasmodium falciparum" infection dynamics [PDF]

, 2012
Malaria is one of the major contributors to the global burden of disease. Worldwide, there were an estimated number of 200 million malaria cases in the year 2008, with a vast majority (85%) of those being in the African Region.
Bretscher, Michael
core   +1 more source

MAVS signaling shapes microglia responses to neurotropic virus infection

Journal of Neuroinflammation
Viral encephalitis is characterized by a series of immunological reactions that can control virus infection in the brain, but dysregulated responses may cause excessive inflammation and brain damage.
Olivia Luise Gern, Andreas Pavlou, Felix Mulenge, Lena Mareike Busker, Luca Ghita, Angela Aringo, Bibiana Costa, Julia Spanier, Inken Waltl, Martin Stangel, Ulrich Kalinke   +10 more
doaj   +1 more source