Results 41 to 50 of about 8,357,189 (268)

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease. [PDF]

, 2009
Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of cerebral malaria is poorly defined and progress in understanding the condition is severely hampered by the inability to study in detail, ante-mortem, the ...
KEVIN N. COUPER, Couper, Kevin N, Riley, Eleanor M, Hafalla, Julius CR, Brian De Souza, J., Hafalla, Julius C R, Couper, Kevin N., JULIUS C. R. HAFALLA, de Souza, J Brian, Riley, Eleanor M., ELEANOR M. RILEY, J. BRIAN de SOUZA   +11 more
core   +1 more source

MAVS signaling shapes microglia responses to neurotropic virus infection

Journal of Neuroinflammation
Viral encephalitis is characterized by a series of immunological reactions that can control virus infection in the brain, but dysregulated responses may cause excessive inflammation and brain damage.
Olivia Luise Gern, Andreas Pavlou, Felix Mulenge, Lena Mareike Busker, Luca Ghita, Angela Aringo, Bibiana Costa, Julia Spanier, Inken Waltl, Martin Stangel, Ulrich Kalinke   +10 more
doaj   +1 more source

Role of serotype and virulence determinants of Streptococcus pyogenes biofilm bacteria in internalization and persistence in epithelial cells in vitro

Frontiers in Cellular and Infection Microbiology, 2023
Streptococcus pyogenes causes a multitude of local and systemic infections, the most common being pharyngitis in children. Recurrent pharyngeal infections are common and are thought to be due to the re-emergence of intracellular GAS upon completion of ...
Feiruz Alamiri, Oscar André, Supradipta De, Pontus Nordenfelt, Anders P. Hakansson   +4 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Glyburide reduces bacterial dissemination in a mouse model of melioidosis [PDF]

, 2013
Background: Burkholderia pseudomallei infection (melioidosis) is an important cause of community-acquired Gram-negative sepsis in Northeast Thailand, where it is associated with a ,40% mortality rate despite antimicrobial chemotherapy. We showed in a
Krause, Kathrin, Ivo Steinmetz (392595), Krause Kathrin, Hanna K de Jong, de Jong, Hanna K., Wiersinga W. Joost, van der Poll Tom, Kathrin Krause (473325), de Jong Hanna K., Koh, Gavin C. K. W., Bast Antje, Katrin Breitbach (473324), Koh Gavin C. K. W., Kager, Liesbeth M., Hanna K. de Jong (304424), W. Joost Wiersinga (33895), Peacock, Sharon J., Hoogendijk, Arjan J., Gavin C K W Koh, Liesbeth M Kager, Wiersinga, W. Joost, Kager, Liesbeth M, Tom van der Poll, Koh, Gavin C K W, W Joost Wiersinga, Antje Bast, Peacock, Sharon J, Gavin C. K. W. Koh (185751), Sharon J. Peacock (35782), Tassili A. Weehuizen (473323), Steinmetz Ivo, Kager Liesbeth M., Sharon J Peacock, Jong, Hanna K. de, Liesbeth M. Kager (367131), Tom van der Poll (33907), Bast, Antje, de Jong, Hanna K, Hoogendijk, Arjan J, Steinmetz, Ivo, Breitbach, Katrin, Breitbach Katrin, Weehuizen Tassili A., Kathrin Krause, Weehuizen, Tassili A., Arjan J. Hoogendijk (473326), Antje Bast (473327), Hoogendijk Arjan J., Wiersinga, W Joost, Peacock Sharon J., Tassili A Weehuizen, van der Poll, Tom, Katrin Breitbach, Arjan J Hoogendijk, Weehuizen, Tassili A, Ivo Steinmetz   +55 more
core   +3 more sources

Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design

Viruses, 2015
In the 26 years since the discovery of Hepatitis C virus (HCV) a major global research effort has illuminated many aspects of the viral life cycle, facilitating the development of targeted antivirals.
Alexander W. Tarr, Tanvi Khera, Kathrin Hueging, Julie Sheldon, Eike Steinmann, Thomas Pietschmann, Richard J. P. Brown   +6 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

SARS-CoV-2 routes of transmission and recommendations for preventing acquisition: joint British Infection Association (BIA), Healthcare Infection Society (HIS), Infection Prevention Society (IPS) and Royal College of Pathologists (RCPath) guidance [PDF]

, 2021
The pandemic of the coronavirus disease 2019 (COVID-19), caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged amid uncertainty about the dynamics of transmission and the possible management options for COVID-19 patients.
Islam, J., Mugglestone, M.A., Wilson, Jennie, Wilson, A.P.R., Ratnaraja, N.V., Stoneham, S.M., Bostock, J., Bak, A., Moses, S.E., Weinbren, M., Loveday, Heather, Rivett, L., Price, J.R.   +12 more
core   +1 more source