Results 21 to 30 of about 8,357,189 (268)

Distinct Long- and Short-Term Adaptive Mechanisms in Pseudomonas aeruginosa

Microbiology Spectrum, 2022
Heterogeneous environments such as the chronically infected cystic fibrosis lung drive the diversification of Pseudomonas aeruginosa populations into, e.g., mucoid, alginate-overproducing isolates or small-colony variants (SCVs).
Michal Koska, Adrian Kordes, Jelena Erdmann, Sven D. Willger, Janne G. Thöming, Heike Bähre, Susanne Häussler   +6 more
doaj   +1 more source

Mucosal immune responses following intestinal nematode infection. [PDF]

, 2014
In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years).
Harris, N. L., P. J. Cooper, Zaph, C, Cooper, P. J., C. Zaph, Cooper, PJ, Harris, NL, Zaph, C., Cooper, Philip, N. L. Harris   +9 more
core   +1 more source

The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy

Journal of Immunology Research, 2017
The human interferon (IFN) response is a key innate immune mechanism to fight virus infection. IFNs are host-encoded secreted proteins, which induce IFN-stimulated genes (ISGs) with antiviral properties.
Janina Bruening, Bettina Weigel, Gisa Gerold   +2 more
doaj   +1 more source

Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Microbiology Spectrum, 2023
Mice are refractory to infection with human-tropic hepatitis C virus (HCV), although distantly related rodent hepaciviruses (RHV) circulate in wild rodents.
Yudi Zhang, Volker Kinast, Julie Sheldon, Nicola Frericks, Daniel Todt, Matthias Zimmer, Neva Caliskan, Richard J. P. Brown, Eike Steinmann, Thomas Pietschmann   +9 more
doaj   +1 more source

Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity

Frontiers in Immunology, 2012
The last decades of Nobel prize-honored research have unequivocally proven a key role of dendritic cells (DCs) at controlling both T cell immunity and tolerance.
Christian Thomas Mayer, Luciana eBerod, Tim D. Sparwasser   +2 more
doaj   +1 more source

A meta-analysis of the effect of dose and age at exposure on shedding of Mycobacterium avium subspecies paratuberculosis (MAP) in experimentally infected calves and cows [PDF]

, 2011
A meta-analysis was performed using all published and one unpublished long-term infection-challenge experiments to quantify the age- and dose-dependence of early and late shedding of Mycobacterium avium subsp. paratuberculosis (MAP) in cattle. There were
Schukken, Y. H., G. F. MEDLEY, M. T. COLLINS, Collins, Michael T., Medley, Graham, Mitchell, R. M., Y. H. SCHUKKEN, R. M. MITCHELL   +7 more
core   +1 more source

CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells

Viruses, 2018
Hepatitis C virus (HCV) enters human hepatocytes using four essential entry factors, one of which is human CD81 (hCD81). The tetraspanin hCD81 contains a large extracellular loop (LEL), which interacts with the E2 glycoprotein of HCV. The role of the non-
Pia Banse, Rebecca Moeller, Janina Bruening, Lisa Lasswitz, Sina Kahl, Abdul G. Khan, Joseph Marcotrigiano, Thomas Pietschmann, Gisa Gerold   +8 more
doaj   +1 more source

Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity

Cells, 2021
The HCV replication cycle is tightly associated with host lipid metabolism: Lipoprotein receptors SR-B1 and LDLr promote entry of HCV, replication is associated with the formation of lipid-rich membranous organelles and infectious particle assembly ...
Francisco J. Zapatero-Belinchón, Rina Ötjengerdes, Julie Sheldon, Benjamin Schulte, Belén Carriquí-Madroñal, Graham Brogden, Laura M. Arroyo-Fernández, Florian W. R. Vondran, Benjamin Maasoumy, Thomas von Hahn, Gisa Gerold   +10 more
doaj   +1 more source

Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection. [PDF]

, 2011
IFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection ...
Couper, Kevin N, de, Souza JB, Riley, Eleanor M, Hafalla, Julius CR, Murungi, Linda, Greig, R, Julius C. R. Hafalla, de Souza, J Brian, Hafalla, Julius C R, Linda Murungi, Villegas-Mendez, Ana, Villegas-Mendez, A, Rachel Greig, Greig, Rachel, J. Brian de Souza, Shaw, TN, Tovah N. Shaw, De Souza, J. Brian, Kevin N. Couper, Shaw, Tovah N, Eleanor M. Riley, Riley, Eleanor M., Hafalla, JC, Ana Villegas-Mendez, Shaw, Tovah N., Couper, KN., Couper, Kevin N., Riley, EM, Murungi, L   +28 more
core   +1 more source

Early Lymphocyte Loss and Increased Granulocyte/Lymphocyte Ratio Predict Systemic Spread of Streptococcus pyogenes in a Mouse Model of Acute Skin Infection

Frontiers in Cellular and Infection Microbiology, 2018
Background: Group A streptococci may induce lymphopenia, but the value of lymphocyte loss as early biomarkers for systemic spread and severe infection has not been examined systematically.Methods: We evaluated peripheral blood cell indices as biomarkers ...
Torsten G. Loof, Aaqib Sohail, Aaqib Sohail, Aaqib Sohail, Mahmoud M. Bahgat, Aravind Tallam, Haroon Arshad, Manas K. Akmatov, Manas K. Akmatov, Marina C. Pils, Ulrike Heise, Andreas Beineke, Frank Pessler, Frank Pessler, Frank Pessler   +14 more
doaj   +1 more source