Results 31 to 40 of about 8,357,189 (268)

Separate signaling events control TCR downregulation and T cell activation in primary human T cells

Immunity, Inflammation and Disease, 2021
Introduction T‐cell antigen receptor (TCR) interaction with cognate peptide:MHC complexes trigger clustering of TCR:CD3 complexes and signal transduction.
Lieve E. H. van derDonk, Louis S. Ates, Jet van derSpek, Laura M. Tukker, Teunis B. H. Geijtenbeek, Jeroen W. J. vanHeijst   +5 more
doaj   +1 more source

Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction

Viruses, 2021
Nef is a multifunctional viral protein that has the ability to downregulate cell surface molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as recently shown, also members of the serine incorporator family (SERINC).
Zita Kruize, Ad C. van Nuenen, Stan W. van Wijk, Arginell F. Girigorie, Karel A. van Dort, Thijs Booiman, Neeltje A. Kootstra   +6 more
doaj   +1 more source

Small non-coding RNAs associated with viral infectious diseases of veterinary importance: potential clinical applications

Frontiers in Veterinary Science, 2016
MicroRNAs (miRNAs) represent a class of small non-coding RNA molecules that can regulate mRNAs by inducing their degradation or by blocking translation.
Mohamed eSamir, Mohamed eSamir, Frank ePessler, Frank ePessler   +3 more
doaj   +1 more source

Quantification of airborne African Swine Fever virus after experimental infection [PDF]

, 2013
Knowledge on African Swine Fever (ASF) transmission routes can be useful when designing control measures against the spread of ASF virus (ASFV). Few studies have focused on the airborne transmission route, and until now no data has been available on ...
Loeffen, W.L.A., Dep Gezondheidszorg Landbouwhuisdieren, Strategic Infection Biology, Stegeman, J.A., Carvalho Ferreira, H.C., de, Quak, S., Weesendorp, E., de Carvalho Ferreira, H.C.   +7 more
core   +1 more source

Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations

Viruses, 2016
Hepatitis E virus (HEV), an important agent of viral hepatitis worldwide, can cause severe courses of infection in pregnant women and immunosuppressed patients. To date, HEV infections can only be treated with ribavirin (RBV).
Daniel Todt, Stephanie Walter, Richard J. P. Brown, Eike Steinmann   +3 more
doaj   +1 more source

Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease

Journal of Neuroinflammation, 2020
Background The type 1 interferon (IFN) response is part of the innate immune response and best known for its role in viral and bacterial infection. However, this pathway is also induced in sterile inflammation such as that which occurs in a number of ...
Ayelet Vardi, Shifra Ben-Dor, Soo Min Cho, Ulrich Kalinke, Julia Spanier, Anthony H. Futerman   +5 more
doaj   +1 more source

Human Schistosome Infection and Allergic Sensitisation [PDF]

, 2012
Several field studies have reported an inverse relationship between the prevalence of helminth infections and that of allergic sensitisation/atopy. Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to ...
Francisca Mutapi, Mutapi, Francisca, Nadine Rujeni, Rujeni, Nadine, David W. Taylor, Taylor, David W.   +5 more
core   +1 more source

Transcriptomic analysis unveils bona fide molecular signatures of microglia under conditions of homeostasis and viral encephalitis

Journal of Neuroinflammation
Microglia serve as a front-line defense against neuroinvasive viral infection, however, determination of their actual transcriptional profiles under conditions of health and disease is challenging.
Felix Mulenge, Olivia Luise Gern, Lena Mareike Busker, Angela Aringo, Luca Ghita, Inken Waltl, Andreas Pavlou, Ulrich Kalinke   +7 more
doaj   +1 more source

Natural reservoirs for homologs of hepatitis C virus

Emerging Microbes and Infections, 2014
Hepatitis C virus is considered a major public health problem, infecting 2%–3% of the human population. Hepatitis C virus infection causes acute and chronic liver disease, including chronic hepatitis, cirrhosis and hepatocellular carcinoma.
Stephanie Pfaender, Richard JP Brown, Thomas Pietschmann, Eike Steinmann   +3 more
doaj   +1 more source

Monocyte and Macrophage Lipid Accumulation Results in Down-Regulated Type-I Interferon Responses

Frontiers in Cardiovascular Medicine, 2022
Macrophages are critical components of atherosclerotic lesions and their pro- and anti-inflammatory responses influence atherogenesis. Type-I interferons (IFNs) are cytokines that play an essential role in antiviral responses and inflammatory activation ...
Lisa Willemsen, Hung-Jen Chen, Cindy P. A. A. van Roomen, Guillermo R. Griffith, Ricky Siebeler, Annette E. Neele, Jeffrey Kroon, Marten A. Hoeksema, Menno P. J. de Winther   +8 more
doaj   +1 more source