Results 121 to 130 of about 1,042,213 (319)

Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]

, 2010
Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M., Huitinga, I., Voehringer, David, Raes, G., van Eijk, Marco, Hoek, Robert M., Hamann, J., Huitinga, Inge, Koning, N., Brouwer, M.S., Raes, Geert, Pouwels, W., Voehringer, D., Koning, Nathalie, Van Eijk, M., Hoek, R.M., Pouwels, Walter, Hamann, Jörg   +17 more
core   +1 more source

De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages

Frontiers in Immunology, 2018
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, is able to efficiently manipulate the host immune system establishing chronic infection, yet the underlying mechanisms of immune evasion are not fully understood.
Philipp Stüve, Lucía Minarrieta, Hanna Erdmann, Catharina Arnold-Schrauf, Maxine Swallow, Melanie Guderian, Freyja Krull, Alexandra Hölscher, Peyman Ghorbani, Jochen Behrends, Wolf-Rainer Abraham, Christoph Hölscher, Tim D. Sparwasser, Luciana Berod   +13 more
doaj   +1 more source

Streptomycin in Experimental Ocular Infections.

Experimental Biology and Medicine, 1947
Summary1. The penetrability of streptomycin through the cornea may be increased by abrasion, inflammation, ion-transfer and wetting agents. 2. No local toxic effects were noted when saline solutions of streptomycin containing up to 10,000 μg per ml were used. With concentrations of 50,000 μg or as a dry powder, delayed healing occurred. 3.
J C, BELLOWS, M M, BURKHOLDER, C J, FARMER   +2 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit

Cells, 2019
The replication cycle of the liver-tropic hepatitis C virus (HCV) is tightly connected to the host lipid metabolism, during the virus entry, replication, assembly and egress stages, but also while the virus circulates in the bloodstream.
Gabrielle Vieyres, Thomas Pietschmann
doaj   +1 more source

Experimental Intraperitoneal Infection of Piglets

Streptococcus suis is a swine bacterial pathogen that predominantly causes disease in weaned piglets characterized by swelling of joints, arthritis, septicemia, meningitis, and sudden death. Intravenous, intramuscular, intraperitoneal, and intranasal infection models were developed to study the bacterial pathogenicity and efficacy of vaccines and ...
Obradovic, Milan, Costa, Matheus de O.
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production [PDF]

, 2005
It is well documented that sex-dependent factors affect susceptibility to infection, with most mouse models demonstrating higher resistance in females.
Bastian Pasche, Helmut Fuchs, Andreas Lengeling, Hrabě de Angelis, M., Franz, T.J., Busch, D.H., Tobias J. Franz, Pasche, B., Busch, Dirk H, Busch, Dirk H., Kalaydjiev, S., Kremmer, E., Valérie Gailus-Durner, Martin Hrabé de Angelis, Kremmer, Elisabeth, Franz, Tobias J., De Angelis, Martin Hrabé, Pasche, Bastian, Dirk H. Busch, Lengeling, A., Fuchs, H., Fuchs, Helmut, Kalaydjiev, Svetoslav, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Lengeling, Andreas, Svetoslav Kalaydjiev, Gailus-Durner, V., Franz, Tobias J, Elisabeth Kremmer   +29 more
core   +1 more source

Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis

Cell Reports, 2018
Summary: In sterile neuroinflammation, a pathological role is proposed for microglia, whereas in viral encephalitis, their function is not entirely clear. Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB).
Chintan Chhatbar, Claudia N. Detje, Elena Grabski, Katharina Borst, Julia Spanier, Luca Ghita, David A. Elliott, Marta Joana Costa Jordão, Nora Mueller, James Sutton, Chittappen K. Prajeeth, Viktoria Gudi, Michael A. Klein, Marco Prinz, Frank Bradke, Martin Stangel, Ulrich Kalinke   +16 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source