Results 101 to 110 of about 8,357,189 (268)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Anaemia in acute HIV-1 subtype C infection. [PDF]

, 2007
BACKGROUND: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin levels during acute and early ...
Auld, Sara C, van Loggerenberg, Francois, Auld Sara C., Loggerenberg, Francois van, Sobieszczyk Magdalena E., Abdool Karim Salim S., Grobler Anneke, Grobler, Anneke, Anneke Grobler, Auld, Sara C., Itua Iriogbe, Mlisana, Koleka Patience., Iriogbe, Itua, Sobieszczyk, Magdalena E, van Loggerenberg, F, Mlisana, K, Iriogbe, Itua., Salim S Abdool Karim, Mlisana, Koleka, Auld, SC, Abdool Karim, Salim Safurdeen., Sobieszczyk, ME, Grobler, A, Magdalena E Sobieszczyk, Williamson, Carolyn., Carolyn Williamson, Francois van Loggerenberg, Abdool Karim, Salim S, Sobieszczyk, Magdalena E., Iriogbe, I, Williamson Carolyn, Abdool Karim, SS, Sara C Auld, Team, for the CAPRISA Acute Infection Study, Williamson, Carolyn, Williamson, C, Grobler, Anna Christina., van Loggerenberg, Francois., van Loggerenberg Francois, Karim, Salim S Abdool, Koleka Mlisana, Iriogbe Itua, Mlisana Koleka, CAPRISA Acute Infection Study Team   +43 more
core   +2 more sources

Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation

Journal of Neuroinflammation, 2018
Background Varicella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection.
Maike Kuhn, Kurt-Wolfram Sühs, Manas K. Akmatov, Frank Klawonn, Junxi Wang, Thomas Skripuletz, Volkhard Kaever, Martin Stangel, Frank Pessler   +8 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The dynamic influence of the DRB1*1101 allele on the resistance of sheep to experimental Teladorsagia circumcincta infection [PDF]

, 2011
Suffolk sheep carrying the DRB1*1101 (previously referred to as-DRB1*0203 or G2) allele have been reported to show increased resistance to natural Teladorsagia circumcincta infection compared to non-carriers.
Sayers Gearoid, Barbara Good, Sayers, Gearoid, Good Barbara, Good, Barbara, Mulcahy, Grace, Sweeney, Torres, Mulcahy Grace, Hassan, Musa, Hanrahan, James P, Sweeney Torres, Grace Mulcahy, Musa Hassan, Hanrahan James P, James P Hanrahan, Hassan, Musa A., Campion, Deirdre P, Gearoid Sayers, Hassan Musa, Deirdre Campion, Hanrahan, James P., Torres Sweeney, Campion Deirdre, Campion, Deirdre   +23 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

IL-10: the master regulator of immunity to infection.

, 2008
IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage.
Couper, Kevin N, Riley, Eleanor M, Blount, Daniel G, Blount, Daniel G., Couper, Kevin N., Riley, Eleanor M.   +5 more
core   +1 more source

De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages

Frontiers in Immunology, 2018
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, is able to efficiently manipulate the host immune system establishing chronic infection, yet the underlying mechanisms of immune evasion are not fully understood.
Philipp Stüve, Lucía Minarrieta, Hanna Erdmann, Catharina Arnold-Schrauf, Maxine Swallow, Melanie Guderian, Freyja Krull, Alexandra Hölscher, Peyman Ghorbani, Jochen Behrends, Wolf-Rainer Abraham, Christoph Hölscher, Tim D. Sparwasser, Luciana Berod   +13 more
doaj   +1 more source