Results 101 to 110 of about 1,042,213 (319)

Experimental infection of human volunteers

The Lancet Infectious Diseases, 2018
Controlled human infection (CHI) trials, in which healthy volunteers are experimentally infected, can accelerate the development of novel drugs and vaccines for infectious diseases of global importance. The use of CHI models is expanding from around 60 studies in the 1970s to more than 120 publications in this decade, primarily for influenza ...
Roestenberg, M., Hoogerwerf, M.A., Ferreira, D.M., Mordmuller, B., Yazdanbakhsh, M.   +4 more
openaire   +5 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study [PDF]

, 2014
Background Asthma exacerbations are frequently triggered by rhinovirus infections. Both asthma and respiratory tract infection can activate haemostasis. Therefore we hypothesized that experimental rhinovirus-16 infection and asthmatic airway inflammation
Kamphuisen, PW, Meijers, JCM, van de Pol, Marianne A., van der Poll, T, Meijers, Joost C. M., Kamphuisen, Pieter Willem, Lutter, R, Wolthers, KC, van der Sluijs, Koenraad F., Sterk, Peter J., Nieuwland, Rienk, de Pol, MAV, Johnston, Sebastian L., Molenkamp, R, Meijers, Joost C.M., Wolthers, Katja C., Sterk, PJ, Bel, Elisabeth H. D., Majoor, Christof J., Molenkamp, Richard, Majoor, CJ, Bel, EHD, Kamphuisen, Pieter W., Bel, Elisabeth H.D., van der Poll, Tom, Nieuwland, R, van der Sluijs, KF, Lutter, Rene, Johnston, SL   +28 more
core   +1 more source

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Human Vaccines & Immunotherapeutics, 2018
Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo ...
D. Korenkov, T. H. O. Nguyen, I. Isakova-Sivak, T. Smolonogina, L. E. Brown, K. Kedzierska, L. Rudenko   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Infection dynamics at within-host and between-host scales

, 2012
Developing and predicting the effect of control measures on the infection dynamics in parasite-host systems with many feedback loops between the different infection processes poses a challenge.
Dep Gezondheidszorg Landbouwhuisdieren, Strategic Infection Biology, Severins, M.   +2 more
core  

Participation of endogenous tumour necrosis factor α in host resistance to cytomegalovirus infection [PDF]

, 1993
Interferon gamma (IFN) represents an essential cytokine involved in murine cytomegalovirus (MCMV) clearance from the salivary gland and the control of horizontal transmission.
Crnkovic, Irena, Pavic, Ivica, Koszinowski, Ulrich H., Lucin, Pero, Polic, Bojan, Jonjic, Stipan   +5 more
core  

Cytomegalovirus microRNAs facilitate persistent virus infection in salivary glands. [PDF]

, 2010
Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability.
Marcinowski, Lisa, Lars Dölken, Astrid Krmpotic, Jonjic, S. (Stipan), Kothe, Sheila, Ruzsics, Zsolt, Tanguy Mélanie, Koszinowski, Ulrich H, Dölken Lars, Krmpotic Astrid, Zsolt Ruzsics, Ruzsics, Z. (Zsolt), Tuddenham, L. (Lee), Jonjic Stipan, Elefant, N. (Naama), Tanguy, Mélanie, Elefant Naama, Pfeffer, S. (Sebastien), Koszinowski, U. (Ulrich H), Marcinowski Lisa, Lisa Marcinowski, Elefant, Naama, Ulrich H Koszinowski, Tuddenham Lee, Altuvia, Yael, Koszinowski Ulrich H., Lee Tuddenham, Stipan Jonjic, Pfeffer Sébastien, Altuvia, Y. (Yael), Kothe Sheila, Sébastien Pfeffer, Tuddenham, Lee, Mélanie Tanguy, Margalit, Hanah, Ruzsics Zsolt, Margalit Hanah, Marcinowski, L. (Lisa), Krmpotic, A. (Astrid), Koszinowski, Ulrich H., Dölken, L. (Lars), Tanguy, M. (Mélanie), Krmpotic, Astrid, Sheila Kothe, Dölken, Lars, Ulrich H. Koszinowski, Yael Altuvia, Naama Elefant, Pfeffer, Sébastien, Kothe, S. (Sheila), Hanah Margalit, Altuvia Yael, Jonjic, Stipan, Margalit, H. (Hanah)   +53 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. [PDF]

, 2012
The balance between pro-inflammatory and regulatory immune responses in determining optimal T cell activation is vital for the successful resolution of microbial infections.
Couper, Kevin N, Claser, C, Riley, Eleanor M, Julius Clemence R Hafalla, Eleanor M Riley, Kevin N Couper, de Souza, J Brian, de Souza, J. Brian, Claser Carla, Renia L., Kevin N. Couper (25399), Grau, GE, Hafalla Julius Clemence R., Laurent Renia (63769), Couper, KN, Hafalla, Julius Clemence R, Grau G.E., Couper Kevin N., Grau, Georges Emile, de Souza, JB, Riley Eleanor M., J. Brian de Souza (25406), Claser C., Renia Laurent, Riley E.M., Hafalla J.C.R., Julius Clemence R. Hafalla (185909), de Souza J.B., de Souza J. Brian, Hafalla, JC, Riley, Eleanor M., Couper K.N., Renia, Laurent, Carla Claser, Georges Emile Grau, Carla Claser (185910), Couper, Kevin N., Georges Emile Grau (185911), Renia, L, Riley, EM, J Brian de Souza, Eleanor M. Riley (25407), Grau Georges Emile, Laurent Renia, Claser, Carla   +44 more
core   +1 more source