Results 111 to 120 of about 1,042,213 (319)

Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation

Journal of Neuroinflammation, 2018
Background Varicella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection.
Maike Kuhn, Kurt-Wolfram Sühs, Manas K. Akmatov, Frank Klawonn, Junxi Wang, Thomas Skripuletz, Volkhard Kaever, Martin Stangel, Frank Pessler   +8 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Estimating the impact of Trypanosoma evansi infection (surra) on buffalo population dynamics in southern Philippines using data from cross-sectional surveys

, 2009
Despite the widespread problem with surra (Trypanosoma evansi) in livestock, there are no published studies on its impact on host populations, probably because of the large financial and time cost involved in performing longitudinal studies.
Dargantes, A.P., Reid, S.A., Reid, S. A., Dobson, R. J., Dargantes, A. P., Mercado, R. T., Dobson, R.J., Mercado, RT.   +7 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden [PDF]

, 2011
BACKGROUND:The study exploits a natural human experimental model of subsistence farmers experiencing chronic and seasonally modified food shortages and infectious burden.
Ngom, Pa T, Solon Juan, Ngom Pa T, Andrew M Prentice, Morgan Gareth, Juan Solon, Prentice Andrew M, Richard Aspinall, Morgan, Gareth, Pa T Ngom, Prentice, Andrew M, Sophie E Moore, Aspinall, Richard, Gareth Morgan, Moore, Sophie E, Solon, Juan, Ngom, Pa T., Moore, Sophie E., Prentice, Andrew M., Aspinall Richard, Moore Sophie E   +20 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Factor v Leiden mutation in severe infection and sepsis

, 2011
In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with
Schouten, Marcel, Levi, Marcel, van't Veer, Cees, van der Poll, Tom   +3 more
core   +1 more source

Selective expansion of viral variants following experimental transmission of a reconstituted feline immunodeficiency virus quasispecies [PDF]

, 2013
Following long-term infection with virus derived from the pathogenic GL8 molecular clone of feline immunodeficiency virus (FIV), a range of viral variants emerged with distinct modes of interaction with the viral receptors CD134 and CXCR4, and ...
Margaret J Hosie, Martin Kraase (276419), McMonagle Elizabeth, Kraase, M., Varela, M., Mariana Varela (81646), Kraase Martin, Nicola Logan (276420), Mariana Varela, Hosie Margaret J., Brian J Willett, Brian J. Willett (276418), Logan Nicola, Elizabeth McMonagle (276421), Willett Brian J., Hosie, M.J., Varela Mariana, Nicola Logan, Logan, N., Willett, B.J., McMonagle, E., Margaret J. Hosie (276422), Elizabeth McMonagle, Martin Kraase   +23 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Antiviral Immune Responses by Human Langerhans Cells and Dendritic Cells in HIV-1 Infection

, 2012
The main route of human immunodeficiency virus-1 (HIV-1) infection is via unprotected sexual intercourse, and therefore, vaginal tissues and male foreskin are viral entry sites.
Linda M. van den Berg, Geijtenbeek, Teunis B. H., Teunis B. H. Geijtenbeek, van den Berg, Linda M.   +3 more
core   +1 more source