Results 261 to 270 of about 1,232,205 (304)

Microarray-Based Genomic Profiling in Low-Dose Radiation Research: Evidence, Limitations, and Translational Perspectives. [PDF]

Int J Mol Sci
Auganbayeva S, Massabayeva M, Chaizhunussova N, Shabdarbayeva D, Pivina L, Orekhov A, Smailova Z, Apbassova S, Sabitova V, Akhmadiyeva T, Kozhanova S, Mukanova D, Lepesbayev M, Baibussinova A, Lipikhina A, Brait Y, Dyussupov A.   +16 more
europepmc   +1 more source

Identifiability analysis for stochastic differential equation models in systems biology

Journal of the Royal Society Interface, 2020
Mathematical models are routinely calibrated to experimental data, with goals ranging from building predictive models to quantifying parameters that cannot be measured.
Alexander P Browning, David J Warne, Kevin Burrage   +2 more
exaly   +2 more sources

Estimation methods for heterogeneous cell population models in systems biology

Journal of the Royal Society Interface, 2018
Heterogeneity among individual cells is a characteristic and relevant feature of living systems. A range of experimental techniques to investigate this heterogeneity is available, and multiple modelling frameworks have been developed to describe and ...
Steffen Waldherr
exaly   +2 more sources

Universally Sloppy Parameter Sensitivities in Systems Biology Models [PDF]

PLoS Computational Biology, 2007
Quantitative computational models play an increasingly important role in modern biology. Such models typically involve many free parameters, and assigning their values is often a substantial obstacle to model development.
Joshua J Waterfall, Kevin Scott Brown, Christopher R Myers   +2 more
exaly   +2 more sources

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

Nature Reviews Molecular Cell Biology, 2014
Eliah R Shamir, Andrew J Ewald
exaly   +2 more sources

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Strategies for coordinating experimentation and modeling in integrative systems biology

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2014
ABSTRACTIn this paper, we provide a novel analysis of the affordances and trade‐offs of different strategies for integrating model‐building and experimentation in integrative systems biology. Unimodal strategies rely on collaboration between experimenters and modelers in distinct laboratories.
MacLeod, Miles Alexander James, Nersessian, Nancy J.   +1 more
openaire   +2 more sources

The Zebrafish as a New Model System for Experimental Biology

Cytology and Genetics, 2018
The emergence of genomics and its use in combination with high-resolution bioimaging for the study of animal development mechanisms provide scientists with information on gene sets and regulation thereof during development. This enabled the identification of the core set of transcription factors involved in the development of invertebrates and ...
Korzh, V., Kondrychyn, I., Winata, C.
openaire   +2 more sources