Results 271 to 280 of about 1,232,205 (304)
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Experimental systems biology approaches reveal interaction mechanisms in model multispecies communities

Trends in Microbiology, 2021
Interactions between microorganisms in multispecies communities are thought to have substantial consequences for the community. Identifying the molecules and genetic pathways that contribute to such interplay is thus crucial to understand as well as modulate community dynamics.
openaire   +2 more sources

The echinoderm larval skeleton as a possible model system for experimental evolutionary biology

genesis, 2014
SummaryThe evolution of various body plans results from the acquisition of novel structures as well as the loss of existing structures. Some novel structures necessitate multiple evolutionary steps, requiring organisms to overcome the intermediate steps, which might be less adaptive or neutral.
Hiroyuki, Koga   +2 more
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Swimming training and herbal nanoformulations as natural remedies to improve sensory-motor impairment in rat midbrain tumor models: system biology, behavioral test, and experimental validation

3 Biotech, 2023
Motor impairment worsens health-related quality of life in patients with primary and metastatic midbrain tumors. Here, 56-male-Wistar rats were divided into eight groups: Normal group, Midbrain Tomur Model group, Model + Exe group, Model + Lipo, Model + Extract, Model + Lipo-Extract, Model + Extract-Exe, Model + Lipo-Extract + Exe. According to the aim,
Fariba Farajizadeh   +3 more
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An interactive visualization tool and data model for experimental design in systems biology

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2008
Experimental design is important, but is often under-supported, in systems biology research. To improve experimental design, we extend the visualization of complex sphingolipid pathways to study biosynthetic origin in SphinGOMAP. We use the ganglio-series sphingolipid dataset as a test bed and the Java Universal Network / Graph Framework (JUNG ...
Shray, Kapoor   +3 more
openaire   +2 more sources

A cooperative strategy for parameter estimation in large scale systems biology models

open access: yesBMC Systems Biology, 2012
BackgroundMathematical models play a key role in systems biology: they summarize the currently available knowledge in a way that allows to make experimentally verifiable predictions. Model calibration consists of finding the parameters that give the best
Alejandro Fernández Villaverde   +2 more
exaly   +2 more sources

Think before you fit: parameter identifiability, sensitivity and uncertaintyin systems biology models

Current Opinion in Systems Biology
Reliable predictions from systems biology models require knowing whether parameters can be estimated from available data, and with what certainty. Identifiability analysis reveals whether parameters are learnable in principle (structural identifiability)
Simon P. Preston   +4 more
semanticscholar   +1 more source

Sensitivity analysis approaches applied to systems biology models

open access: yesIET Systems Biology, 2011
With the rising application of systems biology, sensitivity analysis methods have been widely applied to study the biological systems, including metabolic networks, signalling pathways and genetic circuits.
Zhike Zi
exaly   +2 more sources

Cell Biology of Calcified Tissues: Experimental Models of Differentiation and Mechanisms by Which Local and Systemic Factors Exert their Effects

Connective Tissue Research, 1996
Interpretation of the cell biology literature, as it relates to formation and mineralization of calcifying tissues, is complicated by the plethora of models available. Some culture models use heterogeneous populations of cells while others use relatively homogeneous populations.
B D, Boyan   +3 more
openaire   +2 more sources

Abstract NG01: Effects of altering receptor structure in CAR T cells: Predictions from an experimentally-validated systems biology model

Cancer Research, 2018
Abstract Background and motivation. As T cell immunotherapy applications have expanded, it has become increasingly important to better understand the signaling events that lead to T cell activation. We are particularly interested in chimeric antigen receptor- (CAR-) engineered T cells (CAR-T cells).
Jennifer A. Rohrs   +4 more
openaire   +1 more source

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