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New opportunities for optimal design of dynamic experiments in systems and synthetic biology
Current Opinion in Systems Biology, 2018Recently developed dynamic experimental techniques offer new opportunities for the use of model-based experimental design in the construction and refinement of predictive models of cellular behaviour.
Nathan Braniff, B. Ingalls
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Systems biology primer: the basic methods and approaches.
Essays in Biochemistry, 2018Systems biology is an integrative discipline connecting the molecular components within a single biological scale and also among different scales (e.g.
I. Tavassoly +2 more
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The Spring of Systems Biology-Driven Breeding.
Trends in Plant Science, 2018Genetics and molecular biology have contributed to the development of rationalized plant breeding programs. Recent developments in both high-throughput experimental analyses of biological systems and in silico data processing offer the possibility to ...
J. Lavarenne +4 more
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Quantitative -omic data empowers bottom-up systems biology.
Current Opinion in Biotechnology, 2018The large-scale generation of '-omic' data holds the potential to increase and deepen our understanding of biological phenomena, but the ability to synthesize information and extract knowledge from these data sets still represents a significant challenge.
James T. Yurkovich, B. Palsson
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Identifiability analysis and experimental design for dynamical models in systems biology [PDF]
Mathematical models of the dynamics of cellular processes promise to yield new insights into the underlying biology and their systems' properties. Since the processes are usually high-dimensional and time-resolved experimental data of the processes are sparse, parameter estimation faces the challenges of structural and practical non-identifiability of ...
Raue, Andreas, Timmer, J.
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Optimal Experimental Design for Systems and Synthetic Biology Using AMIGO2.
Methods in molecular biology, 2021E. Balsa-Canto +2 more
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The SEEK: a platform for sharing data and models in systems biology.
Methods in Enzymology, 2011K. Wolstencroft +6 more
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Inverse Problems in Systems Biology: A Critical Review.
Methods in molecular biology, 2018R. Guzzi, T. Colombo, P. Paci
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