Results 91 to 100 of about 5,545,106 (304)
Forum: Qualitative Social Research, 2007 The FOUCAULTian governmentality approach, in relying on a teleology—the ultimate purpose of human endeavour is the quest for ever-growing human reason, a reason that is the universal basis of moral judgements, especially moral judgements about political ...
Gary Wickham, Gavin Kendall
doaj
Knowledge-based Transfer Learning Explanation [PDF]
, 2018 Machine learning explanation can significantly boost machine learning's application in decision making, but the usability of current methods is limited in human-centric explanation, especially for transfer learning, an important machine learning branch ...
Chen, Huajun +4 more
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Explanation and discovery in aerodynamics [PDF]
, 2005 The purpose of this paper is to discuss and clarify the explanations commonly cited for the aerodynamic lift generated by a wing, and to then analyse, as a case study of engineering discovery, the aerodynamic revolutions which have taken place within ...
McCabe, Gordon
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Qualitative Theory and Chemical Explanation [PDF]
, 2002 Roald Hoffmann and other theorists claim that we we ought to use highly idealized chemical models (``qualitative models'') in order to increase our understanding of chemical phenomena, even though other models are available which make more highly ...
Weisberg, Michael
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Mathematical Explanation: A Contextual Approach [PDF]
, 2017 PurposeIn this article, we aim to present and defend a contextual approach to mathematical explanation.MethodTo do this, we introduce an epistemic reading of mathematical explanation.ResultsThe epistemic reading not only clarifies the link between ...
Delarivière, Sven +2 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source