Results 101 to 110 of about 5,545,106 (304)
Explanation-based learning for diagnosis [PDF]
, 1992 Diagnostic expert systems constructed using traditional knowledge-engineering techniques identify malfunctioning components using rules that associate symptoms with diagnoses. Model-based diagnosis (MBD) systems use models of devices to find faults given
Fattah, Yousri El, O'Rorke, Paul
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Interpretation, Explanation and Theories of Meaning
SociologicaWe use the work of Clifford Geertz to examine long-standing questions about the relationship between interpretation and explanation. We extract from Geertz’s work explanatory theories of what we are calling meaning and meaningfulness.
Ann Swidler, Ronald L. Jepperson
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IEEE Access, 2019 Recommender Systems are widely adopted in nowadays services such as e-commerce websites, multimedia streaming platforms, and many others. They help users to find what they are looking for by suggesting relevant items leveraging their past preferences ...
Vito Bellini +3 more
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
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A Star is Born? The Authors, Principles and Objectives of Analytical Sociology
Papers, 2006 This article presents the main features and objectives of the so-called «social mechanisms based explanation» or «analytical sociology». This perspective has gained quite considerable attention in contemporary debate, both for its theoretical novelty as ...
Filippo Barbera
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
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Introduction: Why We Need an Analytical Sociological Theory
Papers, 2006 Sociology has long lived in a stigmatized and pre-paradigmatic state that is highly counterproductive for its status as a scientific discipline.
José A. Noguera
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Eight Other Questions about Explanation [PDF]
, 2018 The tremendous philosophical focus on how to characterize explanatory metaphysical dependence has eclipsed a number of other unresolved issued about scientific explanation. The purpose of this paper is taxonomical.
Potochnik, Angela
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
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