Results 101 to 110 of about 1,959,540 (314)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Invisible Hand Explanations: the Case of Menger's Explanation of the 'Origin of Money' [PDF]
Menger's explanation of the 'Origin of Money' is one of the paradigmatic examples of invisible hand explanations. This paper examines Menger's explanation in detail and comments on the characteristics of invisible hand explanations.invisible hand ...
N. Emrah Aydinonat
core
The operon model and scientific explanation [PDF]
, 2016 It is widely assumed that mechanistic explanations are causal explanations. Many prominent new mechanists endorse interventionism as the correct analysis of explanatory causal models in biology and other fields.
mel.fagan@utah.edu, Melinda Fagan
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Interpretation, Explanation and Theories of Meaning
SociologicaWe use the work of Clifford Geertz to examine long-standing questions about the relationship between interpretation and explanation. We extract from Geertz’s work explanatory theories of what we are calling meaning and meaningfulness.
Ann Swidler, Ronald L. Jepperson
doaj +1 more source
IEEE Access, 2019 Recommender Systems are widely adopted in nowadays services such as e-commerce websites, multimedia streaming platforms, and many others. They help users to find what they are looking for by suggesting relevant items leveraging their past preferences ...
Vito Bellini +3 more
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
A Star is Born? The Authors, Principles and Objectives of Analytical Sociology
Papers, 2006 This article presents the main features and objectives of the so-called «social mechanisms based explanation» or «analytical sociology». This perspective has gained quite considerable attention in contemporary debate, both for its theoretical novelty as ...
Filippo Barbera
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source