Results 121 to 130 of about 1,577,647 (265)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Rare-Disease Diagnosis on the ZebraMap Multimodal Case Report Dataset: A Hybrid Pipeline with Grounded Explainability. [PDF]

Sensors (Basel)
Islam MS, Jamal A, Alkhathlan A.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The symmetries of the Hempelian model of explanation

Kriterion
This article critically examines Hempel's deductive-nomological model. We focus on the model's symmetries produced by requirements of nomic sufficient conditions for explanations.
Túlio Roberto Xavier de Aguiar, Paulo Pimenta Marques   +1 more
doaj  

Cosmin reporting guideline for studies on measurement properties of patient-reported outcome measures and its explanation and elaboration document: translation into Brazilian Portuguese. [PDF]

Qual Life Res
de Arruda GT, Terwee CB, Driusso P, Avila MA, Mokkink LB.   +4 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Editorial: Beyond formal models of reasoning about explanations

Frontiers in Psychology
Barbara Koslowski, Igor Douven, Amy Masnick, Karolina Krzyzanowska, Clark Chinn, Bradley Morris   +5 more
doaj   +1 more source

Eye-Tracking Evidence That Verifiable Explanations Support Visual Evidence Checking in AI-Assisted Chest Radiograph Interpretation. [PDF]

J Eye Mov Res
Han Y, Ouyang W, Du H, Ma M, Wang G.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Explainable Artificial Intelligence in Mammography: A Systematic Review of Methods, Evaluation Practices, and Clinical Readiness. [PDF]

Diagnostics (Basel)
Pesapane F, Rotili A, Penco S, Dominelli V, Priolo F, Marinucci I, Nicosia L, Grasso R, Pravettoni G, Cassano E.   +9 more
europepmc   +1 more source