Results 131 to 140 of about 1,959,540 (314)

Some Remarks On Statistics And Scientific

open access: yes, 2007
and to enlarge such explanations with predictions of what future events will be seen next. What distinguishes scientific from other methods is explanation and prediction by rule, characterized by its explicit and public character.
Marlos Viana   +2 more
core  

The Crux of Crucial Experiments: Duhem’s Problems and Inference to the Best Explanation [PDF]

open access: yes, 2007
Going back at least to Duhem, there is a tradition of thinking that crucial experiments are impossible in science. I analyse Duhem’s arguments and show that they are based on the excessively strong assumption that only deductive reasoning is permissible ...
Weber, Marcel
core  

Scientific explanation and the troubles with Causal explanations in physics

open access: yesRevista Filosofía UIS, 2017
Fifty years ago, Carl Gustav Hempel published his famous book Aspects of Scientific Explanation. Since then the number of publications on this subject has grown exponentially. An occasion like this deserves to be commemorated. In this article I offer a modest tribute to this great methodologist of science.
openaire   +4 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Happiness Prediction With Domain Knowledge Integration and Explanation Consistency

open access: yes
Happiness prediction based on large-scale online data and machine learning models is an emerging research topic that underpins a range of issues, from personal growth to social stability.
Li, Lin   +4 more
core   +1 more source

Qualitative Theory and Chemical Explanation [PDF]

open access: yes, 2002
Roald Hoffmann and other theorists claim that we we ought to use highly idealized chemical models (``qualitative models'') in order to increase our understanding of chemical phenomena, even though other models are available which make more highly ...
Weisberg, Michael
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

The study of the variation and explanation of Tw-DRGs V3.0

open access: yes, 2009
[[abstract]]The purpose of this study was to assess the adequacy of the third version of Tw-DRGs. The adequacy was determined by calculating the coefficient variation (CV) and the coefficient of determination (R2) of the charges and lengths of stay (LOS).
TASI HUI FANG
core  

Scientific Reasoning Is Material Inference: Combining Confirmation, Discovery, and Explanation [PDF]

open access: yes, 2009
Whereas an inference (deductive as well as inductive) is usually viewed as being valid in virtue of its argument form, the present paper argues that scientific reasoning is material inference, i.e., justified in virtue of its content.
Brigandt, Ingo
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy