Results 151 to 160 of about 1,959,540 (314)
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Explanation and environment: the case of psychology
, 2007 The environment in which our cognitive processes operate is crucial for understanding their current form, their reliability, and their function. In the following pages I will look at the role the environment plays in psychological explanations of ...
Wallin, Annika,, Lund University.
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The purpose of this note is to clarify how the idea of "causal depth" can play a role in finding the more "approximately true" explanation through causal comparisons.
Khan, Haider
core
Explanation and Progress in Security Studies Bridging Theoretical Divides in International Relations
, 2014 Explanation and Progress in Security Studies asks why Security Studies, as a central area of International Relations, has not experienced scientific progress in the way natural sciences have-and answers by arguing that the underlying reason is that ...
Chernoff, Fred
core
Funding the National Plan for School Improvement: an explanation [PDF]
, 2013 This paper provides an explanation of the National Plan for School Improvement (NPSI) school funding model, including the new funding that will be provided to participating education systems and schools and the Australian Government’s funding for ...
Marilyn Harrington
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Journal of Philosophical Investigations, 2014 Both the positivist and negativist frameworks of explanation are common in this naturalist proposition that unlike the metaphysical philosophy, reality is embedded only in experimental level.
Faramarz Taghilou , Jalal Peykani
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source