Results 51 to 60 of about 1,959,540 (314)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási +14 more
wiley +1 more source
Self-explanation in adaptive systems [PDF]
, 2012 The behaviour of self adaptive systems can be emergent. The difficulty in predicting the system's behaviour means that there is scope for the system to surprise its customers and its developers.
Whittle, J. +7 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada +6 more
wiley +1 more source
A Pragmatic-Ontic Account of Mechanistic Explanation [PDF]
, 2010 Craver’s (2007) account of explanation in neurobiology offers one of the most sophisticated explications of the mechanism concept. This paper argues that despite groundbreaking advances in understanding mechanistic explanation, serious challenges remain.
Sirtes, Daniel
core
Argument Explanation Complementarity and the Structure of Informal Reasoning
Informal Logic, 2010 : Argument and explanation are distinct forms of reasoning with an underappreciated complementary relationship. In this essay I define these terms precisely, identify the mischief that results from conflating them, elucidate their complementary ...
Gregory Randolph Mayes
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Explanation, unification, and content [PDF]
, 1994 The following is an essay on the notion of scientific explanation as unification. In it a new notion of (logical) content is used to explicate Michael Friedman's notion of "k-atomicity," and to explicate the notion of the surplus content of hypothesis h ...
Gemes, Ken
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Great Explanations: Opinionated Explanations for Recommendations [PDF]
, 2015 Explaining recommendations helps users to make better decisions. We describe a novel approach to explanation for recommender systems, one that drives the recommendation ranking process, while at the same time providing the user with useful insights into the reason why items have been recommended and the trade-offs they may need to consider when making ...
Khalil Muhammad +3 more
openaire +1 more source