Results 101 to 110 of about 15,762 (228)

Prognostic roles of the transcriptional expression of exportins in hepatocellular carcinoma [PDF]

Bioscience Reports, 2019
Abstract Aims: A large number of studies have suggested that exportins (XPOs) play a pivotal role in human cancers. In the present study, we analyzed XPO mRNA expression in cancer tissues and explored their prognostic value in hepatocellular carcinoma (HCC).
Lubiao Chen, Yanlin Huang, Liang Zhou, Yifan Lian, Jialiang Wang, Dongmei Chen, Huan Wei, Mingsheng Huang, Yuehua Huang   +8 more
openaire   +2 more sources

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Integrating novel therapeutic strategies in myeloproliferative neoplasms: Driving disease‐directed progress

British Journal of Haematology, EarlyView.
Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo, Maria Georgiou, Donal P. McLornan, Claire N. Harrison   +3 more
wiley   +1 more source

Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder

, 2013
Background and Objectives MicroRNAs (miRNAs) are aberrantly expressed in cancers. Dicer, Drosha, and Exportin 5 are essential for miRNA processing.
Cai, Zhiming, Liu, Yuchen, Gui, Yaoting, Han, Yonghua   +3 more
core   +1 more source

Cold water immersion in recovery following a single bout resistance exercise suppresses mechanisms of miRNA nuclear export and maturation

Physiological Reports, 2023
Cold water immersion (CWI) following intense exercise is a common athletic recovery practice. However, CWI impacts muscle adaptations to exercise training, with attenuated muscle hypertrophy and increased angiogenesis.
Randall F. D'Souza, Vandre C. Figueiredo, James F. Markworth, Nina Zeng, Christopher P. Hedges, Llion A. Roberts, Truls Raastad, Jeff S. Coombes, Jonathan M. Peake, Cameron J. Mitchell, David Cameron‐Smith   +10 more
doaj   +1 more source

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Resistance to venetoclax has become a critical bottleneck limiting its long‐term clinical benefits. A thorough understanding of the underlying resistance mechanisms and the development of novel strategies to overcome resistance are central to improving survival outcomes in elderly AML patients. Abstract To date, the treatment of acute myeloid leukaemia
Jinlin Zhang, Jile Liu, Mohan Zhao, Xiaoyu Zhang, Linlin Liu, Mengnan Li, Changze Cao, Rui Zhang, Mingfeng Zhao   +8 more
wiley   +1 more source

MicroRNA‐Mediated Autophagy and Cardiovascular Diseases: Exploring the Crossroads of Atherosclerosis and Beyond

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
This graphical abstract illustrates the dynamic bidirectional crosstalk between microRNA biogenesis and autophagy, which serves as a critical regulatory axis in cardiovascular homeostasis. We highlight how specific miRNAs modulate autophagic flux to mitigate vascular inflammation and plaque instability, while concurrently, the autophagic machinery ...
Sepehr Ebrahimi‐Dehkordi, Amir Hossein Barjasteh, Aida Zarei, Sina Bazmi, Sarah Vaseghi, Sara Ashna, Amirreza Solati, Ali Yousefzadeh, Bita Safarzadeh Nasrabad, Zahra Mohammadi, Hamed Haddad Kashani, Mohammad Hossein Pourhanifeh   +11 more
wiley   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

Nuclear entrapment of p33ING1b by inhibition of exportin-1: A trigger of apoptosis in head and neck squamous cell cancer

, 2018
The effect of deregulation of nuclear export mediated by exportin-1, with consequent cellular mislocalization of p33ING1b, a member of the tumor suppressor gene family, has not been previously investigated in head and neck squamous cell cancer (HNSCC ...
Ozdas, Sibel, Sibel í–zdaş
core   +1 more source

sj-tif-1-tct-10.1177_15330338211039132 - Supplemental material for Exportin-T: A Novel Prognostic Predictor and Potential Therapeutic Target for Neuroblastoma

, 2021
Supplemental material, sj-tif-1-tct-10.1177_15330338211039132 for Exportin-T: A Novel Prognostic Predictor and Potential Therapeutic Target for Neuroblastoma by Li-Jia Pan, Jian-Lei Chen, Zhi-Xiang Wu and Ye-Ming Wu in Technology in Cancer Research ...
Li-Jia Pan (11377147), Zhi-Xiang Wu (11377153), Ye-Ming Wu (11377156), Jian-Lei Chen (11377150)   +3 more
core   +1 more source