Results 131 to 140 of about 15,762 (228)

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

eLife, 2015
The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung, Szu-Chin Fu, Chad A Brautigam, Yuh Min Chook   +3 more
doaj   +1 more source

Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA

, 2002
Transport of proteins and RNA into and out of the cell nucleus is mediated largely by a family of RanGTP-binding transport receptors. Export receptors (exportins) need to bind RanGTP for efficient loading of their export cargo.
Nathalie Treichel, Mueller, E.C., Otto, A., Kutay, U., Albrecht Otto, Eva-Christina Müller, Calado, A., Ulrike Kutay, Treichel, N., Angelo Calado   +9 more
core   +1 more source

Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging

Molecular & Cellular Oncology, 2018
Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar, T.G. Thakurta, M.J. Silvestrini, J.R. Johnson, R.A. Reenan, L.R. Lapierre   +5 more
doaj   +1 more source

Ank1 and Ank6 each interact with importin β1 and exportin 1.

, 2018
Whole cell lysates of HeLa cells expressing Flag-tagged BAP, Ank1, Ank6, or Ank7 were incubated with Flag antibody-conjugated agarose beads to immunoprecipitate Flag-tagged proteins and their interacting proteins. Resulting Western blots were probed with
Haley E. Adcox (5180984), Sean M. Evans (2902031), Kyle G. Rodino (2902019), Jason A. Carlyon (690352)   +3 more
core   +1 more source

Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3

Journal of Cancer Research and Clinical Oncology, 2023
Yu Lin, Ming Zhan, Bin Xu
semanticscholar   +1 more source

Importin-β and exportin-5 are indicators of acute viral infection: Correlation of their detection with commercially available detection kits

, 2018
This work focused on immunohistochemistry markers of acute viral infections. Viral infected cells were detected by in situ based methods (reovirus, rabies virus) or cytologic changes (human papillomavirus, molloscum contagiosum virus, herpes simplex ...
Thirukkumaran, Chandini, Andrade, Cecilia Vianna de, Alcina F. Nicol, Chandini Thirukkumaran, Nicol, Alcina F., Cecilia Vianna de Andrade, Gerard J. Nuovo, Nuovo, Gerard J.   +7 more
core   +1 more source

Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression

Cell & Bioscience
Background The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here, we show that expression of alpha-enolase correlates with subcellular localisation and
Morgan L Marshall, Kim YC Fung, David A Jans, Kylie M Wagstaff   +3 more
doaj   +1 more source

In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5

, 2006
Two types of short double-stranded RNA molecules, namely microRNAs (miRNAs) and short interfering RNAs (siRNAs), have emerged recently as important regulators of gene expression.
Petra Schwille, Thomas Ohrt, Karin Birkenfeld, Christophe J. Echeverri, Dennis Merkle   +4 more
core  

Exportin-1 [PDF]

, 2020
openaire   +1 more source

Prognostic Value of Exportin-7 and Its Association with <i>KRAS</i> Status and Autophagy Markers in Small Intestinal Adenocarcinoma. [PDF]

Life (Basel)
Kim JW, Ylaya K, Chung EJ, Jun SY, Hong SM, Chung JY.   +5 more
europepmc   +1 more source