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Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1 [PDF]
Cell Reports, 2021 Aberrant expression of nuclear transporters and deregulated subcellular localization of their cargo proteins are emerging as drivers and therapeutic targets of cancer.
Cuige Zhu, Jason M. Held, Eugene M Oltz
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Exportin-1 is required for the maintenance of the planarian epidermal lineage
International Journal of Biological Macromolecules, 2019Nucleocytoplasmic transport is essential for normal cellular function that mediates cargo transport from the cytoplasm to the nucleus. However, the mechanisms of nucleocytoplasmic transport that integrate stem cell development remain largely unknown. Since it has a large population of stem cells, the planarian flatworm is an ideal system for the study ...
Qingnan Tian, Jiaqian Liu
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Ratjadones inhibit nuclear export by blocking CRM1/exportin 1
Experimental Cell Research, 2003In addition to previously isolated ratjadone A we describe three new members of this family, ratjadones B, C, and D, from another strain of the myxobacterium Sorangium cellulosum. We have investigated the properties of these ratjadones with respect to their activity on mammalian cell lines.
Søren Lykke-Andersen +2 more
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Exportin 1‐independent nuclear export of GAPDH
Cell Biology International, 2003AbstractGlyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) is a key enzyme of the glycolytic pathway. Recent studies have demonstrated an additional role in apoptosis: GAPDH is targeted to the nucleus during apoptotic signalling. This nuclear transport has also been observed in serum‐depleted cells, but it is reversible in fibroblasts, in contrast to ...
Hans-Dirk, Schmitz +2 more
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Targeting Exportin 1 as treatment for cutaneous squamous cell carcinoma.
Journal of Clinical Oncology, 2023e21564 Background: Cutaneous squamous cell carcinomas (cSCC) are among the most frequent solid cancers in humans and in the U.S., cSCC cases are increasing. Molecular mechanisms transitioning premalignant lesions to cancer are not well characterized. As a result, targeted therapies need to be identified to treat these lesions.
Ricky Rana, Laura A. Hansen
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Exportin-1 is critical for cell proliferation and survival in adult T cell leukemia
Investigational New Drugs, 2022Since treatment options for adult T cell leukemia (ATL) associated with human T cell leukemia virus type 1 (HTLV-1) fail to obtain long-term response, novel therapies targeting ATL-dysregulated pathways are necessary. Dysregulated nuclear import and export machinery is common in malignancies. This study aimed to investigate the potential of exportin-1 (
Chie, Ishikawa, Naoki, Mori
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Expression of exportin 1 (XPO1/CRM1) in pancreatic adenocarcinoma.
Journal of Clinical Oncology, 2017327 Background: Exportin 1 (XPO1/CRM1) is a nuclear export chaperone that mediates the nuclear export of several proteins that are essential to growth regulation and tumor suppression. It was found to be overexpressed in several types of human malignancies and overexpression was found to be associated with poor prognosis.
David M Saulino +3 more
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Exportin-1 (XPO1, CRM1) inhibitors for the management of viral infection
Drugs of the Future, 2021A therapeutic gap exists between new emerging infectious diseases and effective treatments. Targeting host factors involved in the replication strategies of evolutionarily diverse viruses may bridge this gap. Exportin-1 (XPO1, also termed chromosome region maintenance 1 [CRM1]) is a cellular nuclear export receptor for cellular and viral protein and ...
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Exploring the exportin-1 inhibitors for COVID-19 and anticancer treatment
Journal of Biomolecular Structure and DynamicsNuclear export protein 1, also known as XPO1, plays a crucial role in cellular homeostasis and assists in the nucleocytoplasmic transfer of ribonucleic acids (RNAs) and proteins. In addition, this nuclear export receptor is essential for the export of a variety of cargo molecules, such as proteins implicated in the immune response, tumor suppression ...
Tanuj, Sharma +9 more
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