Results 121 to 130 of about 12,090 (148)

Exportin-1 is critical for cell proliferation and survival in adult T cell leukemia

Investigational New Drugs, 2022
Since treatment options for adult T cell leukemia (ATL) associated with human T cell leukemia virus type 1 (HTLV-1) fail to obtain long-term response, novel therapies targeting ATL-dysregulated pathways are necessary. Dysregulated nuclear import and export machinery is common in malignancies. This study aimed to investigate the potential of exportin-1 (
Chie, Ishikawa, Naoki, Mori
openaire   +2 more sources

Exploring the exportin-1 inhibitors for COVID-19 and anticancer treatment

Journal of Biomolecular Structure and Dynamics
Nuclear export protein 1, also known as XPO1, plays a crucial role in cellular homeostasis and assists in the nucleocytoplasmic transfer of ribonucleic acids (RNAs) and proteins. In addition, this nuclear export receptor is essential for the export of a variety of cargo molecules, such as proteins implicated in the immune response, tumor suppression ...
Tanuj, Sharma, Tanmoy, Mondal, Venu Venkatarame Gowda, Saralamma, Md Imtaiyaz, Hassan, Chang Joong, Kim, Marianela Patzi, Churqui, Kristina, Nyström, Ketan, Thombare, Mohammad Hassan, Baig, Jae-June, Dong   +9 more
openaire   +2 more sources

Exportin-1 (XPO1, CRM1) inhibitors for the management of viral infection

Drugs of the Future, 2021
A therapeutic gap exists between new emerging infectious diseases and effective treatments. Targeting host factors involved in the replication strategies of evolutionarily diverse viruses may bridge this gap. Exportin-1 (XPO1, also termed chromosome region maintenance 1 [CRM1]) is a cellular nuclear export receptor for cellular and viral protein and ...
openaire   +1 more source

Inhibition of Exportin-1 inhibits endothelial cell ICAM expression

Journal of the American College of Surgeons, 2004
Abstract Introduction: Regulation of the export of adaptor proteins that reside in the nucleus may modulate signal transduction. MyD88 is the principal adaptor protein for Toll/IL-1 receptor signaling. We have observed that MyD88 is a predominantly nuclear protein in murine macrophages.
Mark D. Walsh, Anirban Banerjee, Christine Hamiel, Katherine Barsness, Robert McIntyre   +4 more
openaire   +1 more source

EXPORTIN 1 INHIBITION ATTENUATES NUCLEAR FACTOR-κB-DEPENDENT GENE EXPRESSION

Shock, 2008
Activation of nuclear factor (NF)-kappaB is mediated by signal-induced phosphorylation of IkappaBalpha, subsequent IkappaBalpha degradation, and then translocation of unbound NF-kappaB to the nucleus. Termination of gene expression occurs when IkappaBalpha binds NF-kappaB subunits (Rel A) in the nucleus.
Mark D, Walsh, Christine R, Hamiel, Anirban, Banerjee, Aaron M, Cheng, Guillermo, Escobar, Robert C, McIntyre   +5 more
openaire   +2 more sources

Exportin-1 and epigenetic modifications interaction: more than nuclear transport

Human Cell
Exportin-1 (XPO1) is fundamental in the regulation of nuclear-to-cytoplasm transportation. XPO1 has the ability to transport hundreds of proteins and several different types of mRNAs responsible for proper cellular biology. Deregulation of the XPO1 transportation system aberrantly translocates transcription factors promoting the pathogenesis of ...
Leonidas Benetatos, Eleftheria Hatzimichael, Eleni Kapsali   +2 more
openaire   +2 more sources

SINE compounds activate exportin 1 degradation through an allosteric mechanism

Nature Chemical Biology
Overexpression of exportin 1 (XPO1/CRM1) in cancer cells mislocalizes numerous cancer-related nuclear export cargoes. Covalent selective inhibitors of nuclear export (SINEs), including the cancer drug selinexor, restore proper nuclear localization by blocking XPO1-cargo interaction.
Casey E. Wing, Ho Yee Joyce Fung, Bert Kwanten, Tolga Cagatay, Ashley B. Niesman, Maarten Jacquemyn, Mehdi Gharghabi, Brecht Permentier, Binita Shakya, Rhituparna Nandi, Joseph M. Ready, Trinayan Kashyap, Sharon Shacham, Yosef Landesman, Rosa Lapalombella, Dirk Daelemans, Yuh Min Chook   +16 more
openaire   +2 more sources

SINE compounds activate exportin-1 degradation via an allosteric mechanism

The nuclear export receptor exportin 1 (XPO1/CRM1) is often overexpressed in cancer cells, leading to the mislocalization of numerous cancer-related protein cargoes 1,2 . Selinexor, a covalent XPO1 inhibitor, and other Selective Inhibitor of Nuclear Export (SINEs) restore proper nuclear ...
Casey Elizabeth Wing, Ho Yee Joyce Fung, Bert Kwanten, Tolga Cagatay, Ashley B. Niesman, Maarten Jacquemyn, Mehdi Gharghabi, Brecht Permentier, Binita Shakya, Rhituparna Nandi, Joseph M. Ready, Trinayan Kashyap, Sharon Shacham, Yosef Landesman, Rosa Lapalombella, Dirk Daelemans, Yuh Min Chook   +16 more
openaire   +2 more sources

Identifying novel inhibitors targeting Exportin-1 for the potential treatment of COVID-19

Archives of Microbiology
The nuclear export protein 1 (XPO1) mediates the nucleocytoplasmic transport of proteins and ribonucleic acids (RNAs) and plays a prominent role in maintaining cellular homeostasis. XPO1 has emerged as a promising therapeutic approach to interfere with the lifecycle of many viruses.
Tanuj, Sharma, Tanmoy, Mondal, Sajid, Khan, Marianela Patzi, Churqui, Kristina, Nyström, Ketan, Thombare, Mohammad Hassan, Baig, Jae-June, Dong   +7 more
openaire   +2 more sources

Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation

Nature Chemical Biology
Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contributes to other cellular processes, such as centrosome duplication. Small molecules targeting XPO1 induce cytotoxicity, and selinexor was approved by the Food and Drug Administration in 2019 as a cancer chemotherapy for relapsed multiple
Yi Fan Chen, Maryam Ghazala, Ryan M. Friedrich, Brittany A. Cordova, Frederick N. Petroze, Ramya Srinivasan, Kevin C. Allan, David F. Yan, Joel L. Sax, Kelley Carr, Suzanne L. Tomchuck, Yuriy Fedorov, Alex Y. Huang, Amar B. Desai, Drew J. Adams   +14 more
openaire   +2 more sources