Results 121 to 130 of about 22,508 (191)

Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging

Molecular & Cellular Oncology, 2018
Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar, T.G. Thakurta, M.J. Silvestrini, J.R. Johnson, R.A. Reenan, L.R. Lapierre   +5 more
doaj   +1 more source

Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors. [PDF]

Med, 2022
Coutinho DF, Mundi PS, Marks LJ, Burke C, Ortiz MV, Diolaiti D, Bird L, Vallance KL, Ibáñez G, You D, Long M, Rosales N, Grunn A, Ndengu A, Siddiquee A, Gaviria ES, Rainey AR, Fazlollahi L, Hosoi H, Califano A, Kung AL, Dela Cruz FS.   +21 more
europepmc   +1 more source

Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression

Cell & Bioscience
Background The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here, we show that expression of alpha-enolase correlates with subcellular localisation and
Morgan L Marshall, Kim YC Fung, David A Jans, Kylie M Wagstaff   +3 more
doaj   +1 more source

Novel—and Not So Novel—Inhibitors of the Multifunctional CRM1 Protein

Oncology Reviews
Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex.
Waitman K. Aumann, Waitman K. Aumann, Rafi Kazi, Amanda M. Harrington, Daniel S. Wechsler, Daniel S. Wechsler   +5 more
doaj   +1 more source

Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα-NF-κB p65 Complex. [PDF]

Front Pharmacol, 2022
Chen J, Song D, Xu Y, Wu L, Tang L, Su Y, Xie X, Zhao J, Xu J, Liu Q.   +9 more
europepmc   +1 more source

FPGA-piirin testaus SystemVerilogilla [PDF]

, 2009
Toimeksiantajana opinnäytetyössä oli CENTRIA, Keski-Pohjanmaan Ammattikorkeakoulun tutkimus- kehitys- ja täydennyskoulutusyksikkö. Työn aiheena oli FPGA- testaus SystemVerilogilla.
Aho, Heikki
core  

Exportin-1 [PDF]

, 2020
openaire   +1 more source

CD47 interactions with exportin-1 limit the targeting of m⁷G-modified RNAs to extracellular vesicles. [PDF]

J Cell Commun Signal, 2022
Kaur S, Saldana AC, Elkahloun AG, Petersen JD, Arakelyan A, Singh SP, Jenkins LM, Kuo B, Reginauld B, Jordan DG, Tran AD, Wu W, Zimmerberg J, Margolis L, Roberts DD.   +14 more
europepmc   +1 more source

Enhanced Antitumor Activity by the Combination of Dasatinib and Selinexor in Chronic Myeloid Leukemia

Pharmaceuticals
Background: Chronic myeloid leukemia is a hematological malignancy characterized by the abnormal proliferation of leukemic cells. Despite significant progress with tyrosine kinase inhibitors, such as Dasatinib, resistance remains a challenge.
Mariarita Spampinato, Tatiana Zuppelli, Ilaria Dulcamare, Lucia Longhitano, Domenico Sambataro, Annalisa Santisi, Amer M. Alanazi, Ignazio A. Barbagallo, Nunzio Vicario, Rosalba Parenti, Alessandra Romano, Giuseppe Musumeci, Giovanni Li Volti, Giuseppe A. Palumbo, Francesco Di Raimondo, Anna Nicolosi, Sebastiano Giallongo, Vittorio Del Fabro   +17 more
doaj   +1 more source

Verdinexor, a Selective Inhibitor of Nuclear Exportin 1, Inhibits the Proliferation and Migration of Esophageal Cancer via XPO1/c-Myc/FOSL1 Axis. [PDF]

Int J Biol Sci, 2022
Ou L, Wang X, Cheng S, Zhang M, Cui R, Hu C, Liu S, Tang Q, Peng Y, Chai R, Xie S, Wang S, Huang W, Wang X.   +13 more
europepmc   +1 more source