Results 111 to 120 of about 12,090 (148)

The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors. [PDF]

Mol Cancer Ther, 2017
Farren MR, Hennessey RC, Shakya R, Elnaggar O, Young G, Kendra K, Landesman Y, Elloul S, Crochiere M, Klebanov B, Kashyap T, Burd CE, Lesinski GB.   +12 more
europepmc   +1 more source

Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1. [PDF]

Oncotarget, 2017
Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y.   +13 more
europepmc   +1 more source

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Exportin-1 is required for the maintenance of the planarian epidermal lineage

International Journal of Biological Macromolecules, 2019
Nucleocytoplasmic transport is essential for normal cellular function that mediates cargo transport from the cytoplasm to the nucleus. However, the mechanisms of nucleocytoplasmic transport that integrate stem cell development remain largely unknown. Since it has a large population of stem cells, the planarian flatworm is an ideal system for the study ...
, Jiaqian Liu
exaly   +3 more sources

Ratjadones inhibit nuclear export by blocking CRM1/exportin 1

Experimental Cell Research, 2003
In addition to previously isolated ratjadone A we describe three new members of this family, ratjadones B, C, and D, from another strain of the myxobacterium Sorangium cellulosum. We have investigated the properties of these ratjadones with respect to their activity on mammalian cell lines.
Søren Lykke-Andersen, Florenz Sasse, Jorgen Kjems   +2 more
exaly   +4 more sources

Exportin 1‐independent nuclear export of GAPDH

Cell Biology International, 2003
AbstractGlyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) is a key enzyme of the glycolytic pathway. Recent studies have demonstrated an additional role in apoptosis: GAPDH is targeted to the nucleus during apoptotic signalling. This nuclear transport has also been observed in serum‐depleted cells, but it is reversible in fibroblasts, in contrast to ...
Hans-Dirk, Schmitz, Christine, Dutiné, Jürgen, Bereiter-Hahn   +2 more
openaire   +2 more sources

Targeting Exportin 1 as treatment for cutaneous squamous cell carcinoma.

Journal of Clinical Oncology, 2023
e21564 Background: Cutaneous squamous cell carcinomas (cSCC) are among the most frequent solid cancers in humans and in the U.S., cSCC cases are increasing. Molecular mechanisms transitioning premalignant lesions to cancer are not well characterized. As a result, targeted therapies need to be identified to treat these lesions.
Ricky Rana, Laura A. Hansen
openaire   +1 more source

Expression of exportin 1 (XPO1/CRM1) in pancreatic adenocarcinoma.

Journal of Clinical Oncology, 2017
327 Background: Exportin 1 (XPO1/CRM1) is a nuclear export chaperone that mediates the nuclear export of several proteins that are essential to growth regulation and tumor suppression. It was found to be overexpressed in several types of human malignancies and overexpression was found to be associated with poor prognosis.
David M Saulino, Pamela S Younes, Jennifer M Biley, Mamoun Younes   +3 more
openaire   +1 more source