Results 111 to 120 of about 29,704,271 (175)

Novel—and Not So Novel—Inhibitors of the Multifunctional CRM1 Protein

Oncology Reviews
Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex.
Waitman K. Aumann, Waitman K. Aumann, Rafi Kazi, Amanda M. Harrington, Daniel S. Wechsler, Daniel S. Wechsler   +5 more
doaj   +1 more source

Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors. [PDF]

Med, 2022
Coutinho DF, Mundi PS, Marks LJ, Burke C, Ortiz MV, Diolaiti D, Bird L, Vallance KL, Ibáñez G, You D, Long M, Rosales N, Grunn A, Ndengu A, Siddiquee A, Gaviria ES, Rainey AR, Fazlollahi L, Hosoi H, Califano A, Kung AL, Dela Cruz FS.   +21 more
europepmc   +1 more source

XPO1-dependent nuclear export regulates NS3 localization and promotes DENV-2 replication through mitochondrial remodeling and interferon suppression

Nucleus
Nucleocytoplasmic transport is essential for cellular homeostasis and is frequently exploited by viruses during infection. Although dengue virus (DENV) non-structural protein 3 (NS3) undergoes nuclear trafficking, the role of nuclear export pathways in ...
Selvin Noé Palacios-Rápalo, Jonathan Hernández-Castillo, Luis Adrián De Jesús-González, Daniel Talamas-Lara, Carlos Daniel Cordero-Rivera, Bulmaro Cisneros-Vega, Jose Manuel Reyes-Ruiz, Rosa María del Ángel   +7 more
doaj   +1 more source

Exportin 7, Fumarate Hydratase and Purine Nucleoside Phosphorylase protein expression.

, 2012
Graphs shows expression levels of Exportin 7 (A), Fumarate Hydratase (B) and Purine Nucleoside Phosphorylase (C) in normalized volume for both replicates run per indicated sample.
Jeffrey S. Friedman (174493), Xiuling Xu (174491), Katharina von Löhneysen (174484), Thomas M. Scott (174486), Katrin Soldau (174488)   +4 more
core   +1 more source

A Study of Binding Features between Exportin-t and Thermus thermophilus tRNA^Phe Using a Photo-Cross-Linking Method

, 2016
The interaction of tRNA and its carrier, exportin-t, was studied by photoaffinity cross-linking of randomly s4U-substituted tRNAPheT.th in vitro transcript that was able to form complex with exportin-t and ran·GTP.
Sheng Li (107261)
core   +1 more source

Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription.

, 2004
The increasing numbers of human immunodeficiency virus type 1 (HIV-1) strains that exhibit resistance to antiretroviral agents used at present require the development of new effective antiretroviral compounds.
Bates, Paula J, B. R. Kosloff, Priebe, W, G. M. Shaw, Kosloff, Barry R, W. Priebe, Levy, David N, O. Kutsch, P. J. Bates, Shaw, George M, Kutsch, Olaf, Benveniste, Etty N, E. N. Benveniste, Decker, Julie, D. N. Levy, J. Decker   +15 more
core   +1 more source

Exportin-1 [PDF]

, 2020
openaire   +1 more source

MicroRNA precursors in motion: exportin-5 mediates their nuclear export

, 2004
The discovery of microRNAs (miRNAs) has changed the paradigm of gene regulation, leaving us with numerous exciting questions regarding what these molecules do and how they originate.
Kim, V. Narry
core   +1 more source

Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα-NF-κB p65 Complex. [PDF]

Front Pharmacol, 2022
Chen J, Song D, Xu Y, Wu L, Tang L, Su Y, Xie X, Zhao J, Xu J, Liu Q.   +9 more
europepmc   +1 more source

Strukturelle und funktionelle Analyse der Exportin-Kargo-Erkennung

, 2010
Jeglicher Stoffaustausch zwischen Zellkern und Zellplasma verläuft über sogenannte Kernporenkomplexe gigantische in die Kernhülle eingebettete Kanäle.
Güttler, Thomas
core   +1 more source