Results 91 to 100 of about 29,704,271 (175)

Targeting nuclear export and Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signalling in myelofibrosis: A novel combinatorial strategy that impacts intrinsic and microenvironment‐related pathways

British Journal of Haematology, Volume 209, Issue 3, Page 988-997, September 2026.
Selinexor targets molecular pathways critical to myelofibrosis (MF) progenitor cell fitness and demonstrates complementary activity with ruxolitinib, supporting its potential as a novel disease‐modifying therapeutic strategy for MF. Summary Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (MPN) characterized by splenomegaly, constitutional ...
Trinayan Kashyap, Andrea A. Ellero, Christopher J. Walker, Marie E. Maloof, Min Lu, Lijuan Xia, Ronald Hoffman, Pietro Taverna   +7 more
wiley   +1 more source

Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment

Cells
Despite the major advancements in the repertoire for multiple myeloma (MM) treatment, this disease remains a chronically progressive plasma cell malignancy. Drug resistance and high relapse rates complicate the extended treatment strategies. However, the
Kereshmeh Tasbihi, Heiko Bruns
doaj   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, Volume 293, Issue 17, Page 5121-5139, September 2026.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Hypoxia‐inducible factor‐1a (HIF1a) as a context‐dependent integrator of metabolic stress in skeletal muscle

The Journal of Physiology, Volume 604, Issue 18, Page 7539-7558, 15 September 2026.
Abstract figure legend Hypoxia‐inducible factor‐1a (HIF1a) integrates physiological and pathological inputs in skeletal muscle, including exercise, circadian timing, cytotoxins and disease. These inputs alter mitochondrial oxidative function, redox state, reactive oxygen species, and local oxygen availability, leading to intermittent or sustained HIF1a
Nicole Welch, Pugazhendhi Kannan, Seshu Vardhan Pothabathula, Annette Bellar, Abhishek A. Chakraborty, Saurabh Mishra, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5

Nature Communications
Gene expression in response to environmental stimuli is dependent on nuclear localization of key signaling components, which can be tightly regulated by phosphorylation.
Ho Yee Joyce Fung, Sanraj R. Mittal, Ashley B. Niesman, Jenny Jiou, Binita Shakya, Takuya Yoshizawa, Ahmet E. Cansizoglu, Michael P. Rout, Yuh Min Chook   +8 more
doaj   +1 more source

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

Influence of importin α/β and exportin 1 on equine herpesvirus type 1 (EHV-1) replication in primary murine neurons [PDF]

, 2013
Viruses replicating in the nucleus need to cross the nuclear membrane barrier during infection, therefore disruption of specific nuclear transport pathways is crucial for their replication cycle. In the present study we have investigated the influence of
Cymerys, J., Skwarska, J., Golke, A., Banbura, M W, Slonska, A.   +4 more
core  

Mechanistic Insights from Structural Analyses of Ran-GTPase-Driven Nuclear Export of Proteins and RNAs [PDF]

, 2016
Understanding how macromolecules are rapidly exchanged between the nucleus and the cytoplasm through nuclear pore complexes is a fundamental problem in biology. Exportins are Ran-GTPase-dependent nuclear transport factors that belong to the karyopherin-β
Matsuura, Yoshiyuki
core   +1 more source

Ank1 and Ank6 each interact with importin β1 and exportin 1.

, 2018
Whole cell lysates of HeLa cells expressing Flag-tagged BAP, Ank1, Ank6, or Ank7 were incubated with Flag antibody-conjugated agarose beads to immunoprecipitate Flag-tagged proteins and their interacting proteins. Resulting Western blots were probed with
Haley E. Adcox (5180984), Sean M. Evans (2902031), Kyle G. Rodino (2902019), Jason A. Carlyon (690352)   +3 more
core   +1 more source

Xpo7 is a broad-spectrum exportin and a nuclear import receptor. [PDF]

, 2018
Exportins bind cargo molecules in a RanGTP-dependent manner inside nuclei and transport them through nuclear pores to the cytoplasm. CRM1/Xpo1 is the best-characterized exportin because specific inhibitors such as leptomycin B allow straightforward cargo
Karaca, Samir, Henning Urlaub, Seibel, K., Aksu, Metin, Aksu, M., Urlaub, Henning, Kappert, Christin, Katharina Seibel, Samir Karaca, Christin Kappert, Bohnsack, Markus T., Pleiner, T., Dehne, H., Seibel, Katharina, Bohnsack, M., Markus T. Bohnsack, Heinz-Jürgen Dehne, Görlich, D., Pleiner, Tino, Tino Pleiner, Kappert, C., Urlaub, H., Dirk Görlich, Metin Aksu, Görlich, Dirk, Dehne, Heinz-Jürgen, Karaca, S.   +26 more
core   +1 more source