Results 91 to 100 of about 22,508 (191)

Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage

Nature Communications
Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies and organ preservation, calling for better understanding of cold adaptation.
Xiaomei Zhang, Lihao Ge, Guanghui Jin, Yasong Liu, Qingfen Yu, Weizhao Chen, Liang Chen, Tao Dong, Kiyoharu J. Miyagishima, Juan Shen, Jinghong Yang, Guo Lv, Yan Xu, Qing Yang, Linsen Ye, Shuhong Yi, Hua Li, Qi Zhang, Guihua Chen, Wei Liu, Yang Yang, Wei Li, Jingxing Ou   +22 more
doaj   +1 more source

RNA Nuclear Export: From Neurological Disorders to Cancer [PDF]

, 2017
The presence of a nuclear envelope, also known as nuclear membrane, defines the structural framework of all eukaryotic cells by separating the nucleus, which contains the genetic material, from the cytoplasm where the synthesis of proteins takes place ...
Hautbergue, G.M.
core   +1 more source

Selinexor and Venetoclax Combination in Patients With Relapsed or Refractory Acute Myeloid Leukemia

American Journal of Hematology, Volume 101, Issue 5, Page 1019-1024, May 2026.
ABSTRACT Preclinical studies showed a synergistic antileukemia activity with combination of selective XPO1 inhibitor selinexor (SEL) and venetoclax (VEN), with potential to overcome VEN resistance by reducing the anti‐apoptotic protein MCL1. In an investigator‐sponsored, open‐label, phase Ib study (NCT03955783), adult patients with relapsed or ...
Somedeb Ball, Farrukh T. Awan, Ben K. Tomlinson, Tess Stopczynski, Melissa A. Fischer, Zhiguo Zhao, Kateryna Fedorov, Ashwin Kishtagari, Sanjay R. Mohan, Gregory D. Ayers, Michael T. Byrne, Michael R. Savona   +11 more
wiley   +1 more source

Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment

Cells
Despite the major advancements in the repertoire for multiple myeloma (MM) treatment, this disease remains a chronically progressive plasma cell malignancy. Drug resistance and high relapse rates complicate the extended treatment strategies. However, the
Kereshmeh Tasbihi, Heiko Bruns
doaj   +1 more source

Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors

BMC Cancer, 2018
Background Small intestinal neuroendocrine tumors (SI-NETs) originate from enterochromaffin cells scattered in the intestinal mucosa of the ileum and jejunum.
Elham Barazeghi, Surendra Prabhawa, Olov Norlén, Per Hellman, Peter Stålberg, Gunnar Westin   +5 more
doaj   +1 more source

The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment [PDF]

, 2014
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation ...
Bianconi Maristella, Cascinu Stefano, D'Anzeo Marco, Del Prete Michela, Faloppi Luca, Giampieri Riccardo, SCARTOZZI, MARIO, Silvestris Nicola   +7 more
core   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, Volume 13, Issue 20, 9 April 2026.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage–induced cell senescence [PDF]

, 2016
© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology of the Cell 27 (2016): 1346-1357, doi:10.1091/mbc.E16-01-0025.The coordination of ...
Cekan, Pavol, Chen, Jin-Qiu, Hasegawa, Keisuke, Herrmann, Michelle A., Kalab, Petr, Kumar, Sheetal, Odde, David, Pan, Yu, Tubman, Emily   +8 more
core   +1 more source

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, Volume 13, Issue 23, 23 April 2026.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source

Modulation of anti-tumour immunity by XPO1 inhibitors [PDF]

Exploration of Targeted Anti-tumor Therapy
Exportin-1 (XPO1) is a nuclear export protein that, when overexpressed, can facilitate cancer cell proliferation and survival and is frequently overexpressed or mutated in cancer patients.
Jack G. Fisher, Laura G. Bartlett, Trinayan Kashyap, Christopher J. Walker, Salim I. Khakoo, Matthew D. Blunt   +5 more
doaj   +1 more source