Results 81 to 90 of about 12,090 (148)

XPO1 Inhibition enhances sensitivity to platinum-based chemotherapy in germinal-center B-cell-like-DLBCL cells

Hematology
Purpose: Platinum-based chemotherapy is considered as salvage therapy to relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients. However, treatment failure due to drug resistance occurs in some patients, particularly those with Exportin 1 ...
Qiongqiong Su, Xiaolei Wei, Yongqiang Wei, Ru Feng   +3 more
doaj   +1 more source

Retreatment with talquetamab and pomalidomide in triple‐class–BCMA–GPRC5D refractory myeloma

British Journal of Haematology, Volume 209, Issue 1, Page 320-323, July 2026.
Kian J. Rahbari, Gliceida M. Galarza Fortuna, Bhagirathbhai Dholaria, Douglas W. Sborov, Muhamed Baljevic   +4 more
wiley   +1 more source

Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease

Neurobiology of Disease, 2013
Huntington's disease is characterized by the formation of protein aggregates, which can be degraded by macroautophagy. Here, we studied protein levels and intracellular distribution of p62 and NBR1, two macroautophagy cargo receptors, during disease ...
Laura Rué, Graciela López-Soop, Ellen Gelpi, Marta Martínez-Vicente, Jordi Alberch, Esther Pérez-Navarro   +5 more
doaj   +1 more source

Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging

Molecular & Cellular Oncology, 2018
Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar, T.G. Thakurta, M.J. Silvestrini, J.R. Johnson, R.A. Reenan, L.R. Lapierre   +5 more
doaj   +1 more source

Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers. [PDF]

Sci Transl Med, 2023
Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Shah NS, Chow A, Bhanot UK, Linkov I, Asher M, Yu HA, Qiu J, de Stanchina E, Patel RA, Morrissey C, Haffner MC, Koche RP, Sawyers CL, Rudin CM.   +24 more
europepmc   +1 more source

Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors. [PDF]

Med, 2022
Coutinho DF, Mundi PS, Marks LJ, Burke C, Ortiz MV, Diolaiti D, Bird L, Vallance KL, Ibáñez G, You D, Long M, Rosales N, Grunn A, Ndengu A, Siddiquee A, Gaviria ES, Rainey AR, Fazlollahi L, Hosoi H, Califano A, Kung AL, Dela Cruz FS.   +21 more
europepmc   +1 more source

Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression

Cell & Bioscience
Background The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here, we show that expression of alpha-enolase correlates with subcellular localisation and
Morgan L Marshall, Kim YC Fung, David A Jans, Kylie M Wagstaff   +3 more
doaj   +1 more source

Novel—and Not So Novel—Inhibitors of the Multifunctional CRM1 Protein

Oncology Reviews
Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex.
Waitman K. Aumann, Waitman K. Aumann, Rafi Kazi, Amanda M. Harrington, Daniel S. Wechsler, Daniel S. Wechsler   +5 more
doaj   +1 more source

XPO1-dependent nuclear export regulates NS3 localization and promotes DENV-2 replication through mitochondrial remodeling and interferon suppression

Nucleus
Nucleocytoplasmic transport is essential for cellular homeostasis and is frequently exploited by viruses during infection. Although dengue virus (DENV) non-structural protein 3 (NS3) undergoes nuclear trafficking, the role of nuclear export pathways in ...
Selvin Noé Palacios-Rápalo, Jonathan Hernández-Castillo, Luis Adrián De Jesús-González, Daniel Talamas-Lara, Carlos Daniel Cordero-Rivera, Bulmaro Cisneros-Vega, Jose Manuel Reyes-Ruiz, Rosa María del Ángel   +7 more
doaj   +1 more source

Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα-NF-κB p65 Complex. [PDF]

Front Pharmacol, 2022
Chen J, Song D, Xu Y, Wu L, Tang L, Su Y, Xie X, Zhao J, Xu J, Liu Q.   +9 more
europepmc   +1 more source