Results 81 to 90 of about 29,704,271 (175)

Evolutionary constraints acting on DDX3X protein potentially interferes with Rev-mediated nuclear export of HIV-1 RNA. [PDF]

PLoS ONE, 2010
Differential host-pathogen interactions direct viral replication in infected cells. In HIV-1 infected cells, nuclear export of viral RNA transcripts into cellular cytoplasm is governed by interaction of HIV-1 Rev, Exportin-1 (CRM-1) and DDX3X. Knock down
Deepak Sharma, Jayanta Bhattacharya
doaj   +1 more source

MicroRNA‐Mediated Autophagy and Cardiovascular Diseases: Exploring the Crossroads of Atherosclerosis and Beyond

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
This graphical abstract illustrates the dynamic bidirectional crosstalk between microRNA biogenesis and autophagy, which serves as a critical regulatory axis in cardiovascular homeostasis. We highlight how specific miRNAs modulate autophagic flux to mitigate vascular inflammation and plaque instability, while concurrently, the autophagic machinery ...
Sepehr Ebrahimi‐Dehkordi, Amir Hossein Barjasteh, Aida Zarei, Sina Bazmi, Sarah Vaseghi, Sara Ashna, Amirreza Solati, Ali Yousefzadeh, Bita Safarzadeh Nasrabad, Zahra Mohammadi, Hamed Haddad Kashani, Mohammad Hossein Pourhanifeh   +11 more
wiley   +1 more source

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis [PDF]

Molecular Cell, 2012
Members of the β-karyopherin family mediate nuclear import of ribosomal proteins and export of ribosomal subunits, both required for ribosome biogenesis. We report that transcription of the β-karyopherin genes importin 7 (IPO7) and exportin 1 (XPO1), and several additional nuclear import receptors, is regulated positively by c-Myc and negatively by p53.
Golomb, Lior, Bublik, Debora Rosa, Wilder, Sylvia, Nevo, Reinat, Kiss, Vladimir, Grabušić, Kristina, Volarević, Siniša, Oren, Moshe   +7 more
openaire   +4 more sources

Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage

Nature Communications
Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies and organ preservation, calling for better understanding of cold adaptation.
Xiaomei Zhang, Lihao Ge, Guanghui Jin, Yasong Liu, Qingfen Yu, Weizhao Chen, Liang Chen, Tao Dong, Kiyoharu J. Miyagishima, Juan Shen, Jinghong Yang, Guo Lv, Yan Xu, Qing Yang, Linsen Ye, Shuhong Yi, Hua Li, Qi Zhang, Guihua Chen, Wei Liu, Yang Yang, Wei Li, Jingxing Ou   +22 more
doaj   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

Modulation of anti-tumour immunity by XPO1 inhibitors [PDF]

Exploration of Targeted Anti-tumor Therapy
Exportin-1 (XPO1) is a nuclear export protein that, when overexpressed, can facilitate cancer cell proliferation and survival and is frequently overexpressed or mutated in cancer patients.
Jack G. Fisher, Laura G. Bartlett, Trinayan Kashyap, Christopher J. Walker, Salim I. Khakoo, Matthew D. Blunt   +5 more
doaj   +1 more source

The Arabidopsis thaliana F-box gene HAWAIIAN SKIRT is a new player in the microRNA pathway. [PDF]

PLoS ONE, 2017
In Arabidopsis, the F-box HAWAIIAN SKIRT (HWS) protein is important for organ growth. Loss of function of HWS exhibits pleiotropic phenotypes including sepal fusion.
Xuebin Zhang, Dasuni Jayaweera, Janny L Peters, Judit Szecsi, Mohammed Bendahmane, Jeremy A Roberts, Zinnia H González-Carranza   +6 more
doaj   +1 more source

MicroRNA‐Mediated Placental Maladaptation in Preeclampsia Pathogenesis

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Graphical representation of miRNA‐mediated placental maladaptation in preeclampsia. Under normal pregnancy conditions, balanced expression of beneficial miRNAs (miR‐126‐3p, miR‐18a/b‐5p, miR‐144‐3p, miR‐378a‐5p, and miR‐146a‐5p) promotes trophoblast proliferation, migration and invasion, spiral artery remodeling, angiogenesis, mitochondrial function ...
Sarbani Saha, Rupasri Ain
wiley   +1 more source

Representation of Exportin-5 orthologs annotations.

, 2014
Common terms between species are displayed in blue. The terms annotating only the human ortholog are displayed in red. Part A of this figure displays the MF annotations of the human and rat orthologs of Exportin-5.
Charles Bettembourg (116573), Olivier Dameron (469875), Christian Diot (116581)   +2 more
core   +1 more source

Translocation Biosensors – Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

Sensors, 2009
Fluorescent protein biosensors are powerful cellular systems biology tools for dissecting the complexity of cellular processes with high spatial and temporal resolution. As regulated nucleo-cytoplasmic transport is crucial for the modulation of numerous (
Roland H. Stauber, Shirley K. Knauer, Jens Peter von Kries, Carolin Bier, Verena Fetz   +4 more
doaj   +1 more source