Results 101 to 110 of about 29,704,271 (175)

Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Nature Communications
Parental experiences can affect the phenotypic plasticity of offspring. In locusts, the population density that adults experience regulates the number and hatching synchrony of their eggs, contributing to locust outbreaks.
Ya′nan Zhu, Jing He, Jiawen Wang, Wei Guo, Hongran Liu, Zhuoran Song, Le Kang   +6 more
doaj   +1 more source

Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder

, 2013
Background and Objectives MicroRNAs (miRNAs) are aberrantly expressed in cancers. Dicer, Drosha, and Exportin 5 are essential for miRNA processing.
Cai, Zhiming, Liu, Yuchen, Gui, Yaoting, Han, Yonghua   +3 more
core   +1 more source

Targeting Exportin-1 to Inhibit HTLV-1 Infection

, 2020
Human T-cell Leukemia Virus Type-1 (HTLV-1) is a complex human retrovirus that infects around 20 million people globally. Transmission of this retrovirus occurs by sexual intercourse, contaminated blood, and from mother to child by breastfeeding.
Norton, Christopher, NC DOCKS at East Carolina University   +1 more
core   +2 more sources

XPO1 Inhibition enhances sensitivity to platinum-based chemotherapy in germinal-center B-cell-like-DLBCL cells

Hematology
Purpose: Platinum-based chemotherapy is considered as salvage therapy to relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients. However, treatment failure due to drug resistance occurs in some patients, particularly those with Exportin 1 ...
Qiongqiong Su, Xiaolei Wei, Yongqiang Wei, Ru Feng   +3 more
doaj   +1 more source

Binding of Carbonic Anhydrase IX to 45S rDNA Genes Is Prevented by Exportin-1 in Hypoxic Cells

, 2015
Carbonic anhydrase IX (CA IX) is a surrogate marker of hypoxia, involved in survival and pH regulation in hypoxic cells. We have recently characterized its interactome, describing a set of proteins interacting with CA IX, mainly in hypoxic cells ...
Santoriello, Margherita, Luca Alfredo Paolella, Monteleone, Francesca, Jean-Yves Winum, Mariangela Sabatella, Nicola Zambrano, Crifò, Bianca, Boffo, Francesca Ludovica, Francesca Monteleone, Margherita Santoriello, Vitale, Monica, Emanuele Sasso, Giuseppina Minopoli, Winum, Jean-Yves, Francesca Boffo, Paolella, Luca Alfredo, Minopoli, Giuseppina, Sasso, Emanuele, Daniela Sarnataro, Sarnataro, Daniela, Zambrano, Nicola, Sabatella, Mariangela, Garbi, Corrado, Corrado Garbi, Monica Vitale, Bianca Crifò   +25 more
core   +1 more source

Controlling protein transport by small molecules [PDF]

, 2011
Many proteins are transported from the nucleus to the cytoplasm by the exportin CRM1, which recognizes cargo proteins through a leucine rich nuclear export signal (NES).
Karl Gademann, Gademann, Karl
core   +1 more source

Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging

Molecular & Cellular Oncology, 2018
Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar, T.G. Thakurta, M.J. Silvestrini, J.R. Johnson, R.A. Reenan, L.R. Lapierre   +5 more
doaj   +1 more source

Identification of the Ank1 and Ank6 domains that are essential for the ability to co-immunoprecipitate p65, importin β1, and exportin 1.

, 2018
Whole cell lysates of HeLa cells expressing the indicated Flag-tagged proteins were incubated with Flag antibody-conjugated agarose beads to immunoprecipitate Flag-tagged proteins and their interacting proteins.
Haley E. Adcox (5180984), Sean M. Evans (2902031), Kyle G. Rodino (2902019), Jason A. Carlyon (690352)   +3 more
core   +1 more source

세포노화 과정 중 G-actin의 핵 내 축적: Exportin 6와 Ran-GTP의 발현 및 분포변화

, 2008
Actin is a highly conserved, ubiquitous cytoskeletal protein, which contains two leucine-rich nuclear export signal (NES) sequences in the middle of the molecule.
박, 수현
core   +1 more source

Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression

Cell & Bioscience
Background The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here, we show that expression of alpha-enolase correlates with subcellular localisation and
Morgan L Marshall, Kim YC Fung, David A Jans, Kylie M Wagstaff   +3 more
doaj   +1 more source