Results 101 to 110 of about 22,508 (191)

2026 Update on the Management of Diffuse Large B‐Cell Lymphoma

American Journal of Hematology, Volume 101, Issue 4, Page 832-863, April 2026.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong, Emily B. Tomasulo, Stefan K. Barta   +2 more
wiley   +1 more source

Translocation Biosensors – Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

Sensors, 2009
Fluorescent protein biosensors are powerful cellular systems biology tools for dissecting the complexity of cellular processes with high spatial and temporal resolution. As regulated nucleo-cytoplasmic transport is crucial for the modulation of numerous (
Roland H. Stauber, Shirley K. Knauer, Jens Peter von Kries, Carolin Bier, Verena Fetz   +4 more
doaj   +1 more source

Selinexor overcomes hypoxia-induced drug resistance in multiple myeloma [PDF]

, 2017
Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity
Azab, Abdel Kareem, Azab, Feda, de la Puente, Pilar, Landesman, Yosef, Muz, Barbara   +4 more
core   +3 more sources

Chromosome‐scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1

Insect Science, Volume 33, Issue 2, Page 640-664, April 2026.
Anastrepha fraterculus sp. 1 is a major fruit fly pest in Argentina, currently controlled through chemical treatments and traps. This study aims to enhance the genomic understanding of this species to support the development of sterile insect technique as well as the use of innovative technologies.
Máximo Rivarola, Claudia A. Conte, Pierre Berube, Shu‐Huang Chen, M. Cecilia Giardini, Alejandra C. Scannapieco, Fabián H. Milla, María C. Soria, Romina M. Russo, Juan P. Wulff, Haig H. Djambazian, Rolando R. Pomar, Alfred M. Handler, Kostas Bourtzis, Ioannis Ragoussis, Silvia B. Lanzavecchia   +15 more
wiley   +1 more source

Differential expression of exportin 1 in cancers of the breast.

, 2022
Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer.
openaire   +1 more source

Structures of Ras superfamily effector complexes: What have we learnt in two decades? [PDF]

, 2015
The Ras superfamily small G proteins are master regulators of a diverse range of cellular processes and act via downstream effector molecules. The first structure of a small G protein-effector complex, that of Rap1A with c-Raf1, was published 20 years ...
Mott, Helen R, Owen, Darerca
core   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells. [PDF]

, 2017
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed \u27small RNA zipper\u27.
Chen, Yi-Han, Deng, Shengqiong, Fan, Huiming, Li, Wenshu, Liu, Cuicui, Liu, Zhongmin, Lu, Ying, Lü, Jinhui, Meng, Lingyu, Pestell, Richard G., Qiao, Jing, Wang, Guangxue, Yu, Zuoren, Zhang, Chuyi, Zhang, Yuzhen, Zhao, Qian, Zhen, Lixiao   +16 more
core   +2 more sources

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, Volume 13, Issue 16, 18 March 2026.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Deficiency of Pkc1 activity affects glycerol metabolism in Saccharomyces cerevisiae [PDF]

, 2005
In pressProtein kinase C is apparently involved in the control of many cellular systems: the cell wall integrity pathway, the synthesis of ribosomes, the appropriated reallocation of transcription factors under specific stress conditions and also the ...
Alepuz P.M., Andrews P.D., Bill R.M., Boukaba A., Brandao R.L., Buehrer B.M., Castro I.M., Celenza J.L., Chang M., Davie J.K., Delley P.A., DeVit M.J., Estruch F., Estruch F., Goldstein A., Grauslund M., Gray J.V., Hardie D.G., Harrison J.C., Heinisch J.J., Herrero P., Hohmann S., Holst B., Hong S., Ito H., Kingston R.E., Lages F., Lages F., Larsson C., Lowry O.H., Luyten K., Mazzoni C., Nanduri J., Nath N., Neves L., Oliveira R., Ozcan S., Park H., Pavlik P., Philips J., Ronnow B., Sal G., Salgado A.P.C., Sanger F., Schmitz H.-P., Schuller H.-J., Sekiya-Kawasaki M., Smith R., Souza M.A.A., Sprague G.F., Sreenivas A., Sutherland F.C., Tamas M.J., Wang A., Watson A.D., Wojda I., Young E.T., Zhao C.   +57 more
core   +1 more source