Results 301 to 310 of about 528,613 (372)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Bioluminescent Probes for Multiplexed RNA Imaging. [PDF]

J Am Chem Soc
Fuller EB, Cole KH, Halbers LP, Chan CET, Ng KK, Scipioni L, Gohlke C, Digman MA, Steward O, Prescher JA, Lupták A.   +10 more
europepmc   +1 more source

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Expressed Sequence Tags: An Overview

Methods in molecular biology, 2009
Expressed sequence tags (ESTs) are fragments of mRNA sequences derived through single sequencing reactions performed on randomly selected clones from cDNA libraries. To date, over 45 million ESTs have been generated from over 1400 different species of eukaryotes.
John, Parkinson, Mark, Blaxter
openaire   +3 more sources

Expressed Sequence Tags: Analysis and Annotation

Methods in molecular biology (Clifton, N.J.), 2004
Expressed sequence tags (ESTs) present a special set of problems for bioinformatic analysis. They are partial and error-prone, and large datasets can have significant internal redundancy. To facilitate analysis of small EST datasets from in-house projects, we present an integrated "pipeline" of tools that take EST data from sequence trace to database ...
John Parkinson, Mark L Blaxter
exaly   +2 more sources

ANALYSIS OF GRAPE EXPRESSED SEQUENCES TAGS

Acta Horticulturae, 2000
The Australian Agricultural Research Institute is embarking on a large-scale grape EST analysis project. cDNA libraries are being prepared from a range of tissues, developmental stages and cultivars with the aim of producing a database of up to 50,000 sequences, covering a high proportion of grape genes.
Ablett, E. M., Lee, L. S., Henry, R. J.
openaire   +2 more sources

Statistical Analysis of Expressed Sequence Tags

2009
Expressed sequence tag (EST) surveys are an efficient way to characterize large numbers of genes from an organism. The rate of gene discovery in an EST survey depends on the degree of redundancy of the cDNA libraries from which sequences are obtained. We consider statistics for the comparison of EST libraries based upon the frequencies with which genes
Edward, Susko, Andrew J, Roger
openaire   +2 more sources

ESTMAP: a system for expressed sequence tags mapping on genomic sequences

IEEE Transactions on Nanobioscience, 2003
The completion of a number of large genome sequencing projects emphasizes the importance of protein-coding gene predictions. Most of the problems associated with gene prediction are caused by the complex exon-intron structures commonly found in eukaryotic genomes.
Milanesi L, Rogozin IB
openaire   +2 more sources