Results 91 to 100 of about 5,546,459 (287)

A role for p53 in telomere protection

Molecular & Cellular Oncology, 2017
Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress.
Stephen Tutton, Paul M. Lieberman
doaj   +1 more source

Investigation of CD73 expression in Iraqi patient women with breast tumors

, 2023
R. Mohsin, Jasim Mohamad, Raghdah Mohsin, A Kolak, M Kamiska, K Sygit, A Budny, D Surdyka, B Kukieka-Budny, Nas Alwan, F Tawfeeq, Nag Mallah, Y Feng, M Spezia, S Huang, C Yuan, Z Zeng, L Zhang, A Hafez, H Mohamed, T Hussein, Iaa Tamemi, Y Suhail, M Cain, K Vanaja, P Kurywchak, A Levchenko, R Kalluri, N Alrawi, A Green, D Powe, E Rakha, D Soria, C Lemetre, C Nolan, V Jayashree, M Velraj, T Iwamoto, Y Kajiwara, Y Zhu, S Iha, F Fisusi, E Akala, B Allard, D Allard, L Buisseret, J Stagg, H Choi, H Oh, S Park, Y Jeong, N Messaoudi, I Cousineau, E Arslanian, D Henault, D Stephen, F Vandenbroucke-Menu, P Rocha, R Salazar, J Zhang, D Ledesma, J Solorzano, B Mino, P Ismail, A Yousif, R Wang, Y Zhang, X Lin, Y Gao, Y Zhu, Z Gao, K Dong, H Zhang, Y Jeong, H Oh, H Choi, S Park, Wang Zhou, X Zhou, T Ma, D Chen, S Zhi, X, J De Arajo, V Kerkhoff, Oliveira De, Sfv Maciel, E De Resende, D Silva, T Jiang, X Xu, M Qiao, X Li, C Zhao, F Zhou, Falih Soliman, N, Jasim Mohamad, B, I Monteiro   +99 more
openalex   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Expression Signature

, 2013
he prostate gland can be the site of multiple neoplastic transformation events, many of which give rise only to latent prostate cancer that does not progress to clinically detectable disease. While evidence of major subtypes of prostate cancer is lacking at the histopathological level, recent genomic analyses have provided increasing evidence for ...
STAIBANO, STEFANIA, Celetti, Angela
openaire   +4 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Differentiation of Porcine TLR4 Gene Expression in Piglets of Different Ages [PDF]

, 2011
ZX Pan, Z. Chen, L. Liu, Yueping Cao, Kaihui Xie, Jie Yang, Xing Huang, Shuqing Wu, W.B. Bao   +8 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Enhancing Hepatic MBOAT7 Expression Does Not Improve Nonalcoholic Steatohepatitis in Mice [PDF]

, 2022
Martin C. Sharpe, Kelly D. Pyles, Taylor Hallcox, Dakota R. Kamm, Michaela Piechowski, Bryan Fisk, Carolyn J. Albert, Danielle Carpenter, Barbara Ulmasov, David A. Ford, Brent A. Neuschwander‐Tetri, Kyle S. McCommis   +11 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source