Results 231 to 240 of about 134,736 (276)

Sperm Sexing in Selected Animals and Humans: Methods, Applications, and Future Prospects

Andrology, EarlyView.
ABSTRACT Background Sperm sexing is a technique that enables the selection of offspring sex by sorting spermatozoa based on their sex chromosomes. This technology has gained increasing attention due to its potential applications in both animal breeding and human‐assisted reproduction.
Domrazek Kinga, Jurka Piotr
wiley   +1 more source

Characterizing the Relationship between Expression Quantitative Trait Loci (eQTLs), DNA Methylation Quantitative Trait Loci (mQTLs), and Breast Cancer Risk Variants. [PDF]

Cancers (Basel)
Ho PJ, Khng A, Tan BK, Khor CC, Tan EY, Lim GH, Yuan JM, Tan SM, Chang X, Tan VKM, Sim X, Dorajoo R, Koh WP, Hartman M, Li J.   +14 more
europepmc   +1 more source

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, EarlyView.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Mendelian randomization based on genome-wide association studies and expression quantitative trait loci, predicting gene targets for the complexity of osteoarthritis as well as the clinical prognosis of the condition. [PDF]

Front Med (Lausanne)
Yan Y, He J, Xu Z, Wang C, Hu Z, Zhang C, Cheng W.   +6 more
europepmc   +1 more source

From barriers to benefits: A personalized sleep intervention enhances sleep duration and emotional health in chronic short sleepers

British Journal of Psychology, EarlyView.
Abstract This pilot study evaluated a personalized sleep intervention incorporating motivational interviewing techniques to address sleep barriers, along with tailored sleep hygiene and extension for chronic short sleepers. Eleven university students completed a 14‐day sequential intervention (baseline, sleep hygiene and a combined phase adding 90‐min ...
Wei Wang, Ho Yin Derek Ma, Ming Ming Chiu, Shu Fai Cheung, C. Harry Hui, Mark Lawrence Wong, Janet Hui‐wen Hsiao, Rong Wei Sun, Yeuk Ching Lam, Akira Basa Okabe, Chin Ho Chan, Esther Yuet Ying Lau   +11 more
wiley   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, EarlyView.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Polygenic Risk Score Predicts Prostate Cancer Risk Independent of Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Type 2 diabetes mellitus (T2DM) has been inversely associated with prostate cancer (PrCa) risk. However, it remains unclear whether a polygenic risk score (PRS) for PrCa can effectively stratify risk among men with T2DM. The primary objective of this study was to assess whether a PrCa PRS predicts PrCa risk independently of T2DM status ...
Guk Jin Lee, Sang‐Hyuk Jung, Jonghyun Lee, Ki Won Moon, Penn Medicine Biobank, Daniel J. Rader, Marylyn D. Ritchie, JoEllen Weaver, Nawar Naseer, Giorgio Sirugo, Afiya Poindexter, Yi‐An Ko, Kyle P. Nerz, Meghan Livingstone, Fred Vadivieso, Stephanie DerOhannessian, Teo Tran, Julia Stephanowski, Salma Santos, Ned Haubein, Joseph Dunn, Colleen Morse Kripke, Marjorie Risman, Renae Judy, Colin Wollack, Anurag Verma, Shefali S. Verma, Scott Damrauer, Yuki Bradford, Scott Dudek, Theodore Drivas, Jae‐Seung Yun, Dokyoon Kim   +32 more
wiley   +1 more source

Proteomic Profiling of Plasma to Uncover Novel Intervention Targets and Prognostic Biomarkers for Chronic Liver Diseases

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The burden of chronic liver disease (CLD) is increasing. This study aims to identify protein markers for CLD and its progression, and develop a protein‐based risk prediction model. Materials and Methods We used proteome‐wide Mendelian randomization (MR), Bayesian colocalization and summary‐data‐based MR with proteomic data from deCODE ...
Xinxuan Li, Jing Sun, Jianhui Zhao, Fangyuan Jiang, Meng Zhang, Hao Wu, Shuai Yuan, Xue Li, Juan Lu, Christos S. Mantzoros   +9 more
wiley   +1 more source

Perceived Confidence in Managing Medical Emergencies Among Dental Students: The Significance of Technical Knowledge and Emotional Intelligence

European Journal of Dental Education, EarlyView.
ABSTRACT Aim This study aimed to evaluate the technical, practical and emotional factors associated with the self‐reported confidence of dental students in managing medical emergencies and urgent situations. Materials and Methods A cross‐sectional study was conducted with 100 students enrolled in the clinical courses of a public dentistry programme in ...
Tecianny Nunes de Aquino, Taysllan Torquato Benevides, Maria Luísa de Assis Braga, Annyelle Anastácio Cordeiro, Ana Flávia Granville‐Garcia, Érick Tássio Barbosa Neves   +5 more
wiley   +1 more source