Results 241 to 250 of about 134,736 (276)

Impact of an Educational Intervention on Dental Students' Practical Motivation in Early Oral Cancer Detection: Assessment With the “Perceived Locus of Causality–University Version” Questionnaire

European Journal of Dental Education, EarlyView.
ABSTRACT Introduction Early detection of oral cancer significantly improves prognosis, but diagnostic delays persist due to professional and educational factors. This study aimed to evaluate the impact of an educational intervention on dental students' motivation toward oral cancer detection, using the Perceived Locus of Causality–University Version ...
Esther Delgado‐Somolinos, Jesus Rodriguez‐Molinero, Blanca del Carmen Miguelañez‐Medrán, Rosario Ramírez‐Puerta, Inmaculada Corral‐Liria, Marta Elena Losa‐Iglesias, Manuel Norberto Sánchez‐de Miguel, Antonio Francisco López‐Sánchez   +7 more
wiley   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

From inclusion to (neuro)divergent safe space in organizations

International Journal of Management Reviews, EarlyView.
Abstract Neurodiversity in organizations remains an underexplored area, leaving gaps in understanding how organizations may create safe spaces for and with neurodivergent employees. This article engages with current neuro‐inclusion debates and advocates for a shift towards a framework of (neuro)divergent safe space, offering a more refined exploration ...
Frederike Scholz, Amber Kersten, Joanna Maria Szulc   +2 more
wiley   +1 more source

Expression quantitative trait loci in human brain tissues

openaire   +1 more source

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Statistical Methods for Expression Quantitative Trait Loci (eQTL) Mapping

Biometrics, 2006
Summary Traditional genetic mapping has largely focused on the identification of loci affecting one, or at most a few, complex traits. Microarrays allow for measurement of thousands of gene expression abundances, themselves complex traits, and a number of recent investigations have considered these measurements as phenotypes in mapping studies ...
Kendziorski, C. M., Chen, M., Yuan, M., Lan, H., Attie, A. D.   +4 more
openaire   +4 more sources

Detection and interpretation of expression quantitative trait loci (eQTL)

Methods, 2009
Analysis of expression quantitative trait loci (eQTL) provides a means for detecting transcriptional regulatory relationships at a genome-wide scale. Here we explain the eQTL analysis pipeline, we introduce publicly available tools for the statistical analysis, and we discuss issues that might complicate the eQTL mapping process.
Michaelson, Jacob J., Loguercio, Salvatore, Beyer, Andreas   +2 more
openaire   +4 more sources

Proximity Model for Expression Quantitative Trait Loci (eQTL) Detection

Biometrics, 2007
SummaryExpression quantitative trait loci (eQTL) are loci or markers on the genomes that are associated with gene expression. It is well known to biologists that some (cis) genetic influences on expression occur over short distances on the genome while some (trans) influences can operate remotely.
Gelfond, Jonathan A. L., Ibrahim, Joseph G., Zou, Fei   +2 more
openaire   +3 more sources