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Genome stability and gene expression
2012This chapter assesses genome stability and gene expression. Genetic information is stored in DNA in the order of nitrogenous bases. Information in DNA must be accurately copied, ready to be passed to the next cell generation. DNA replication is the accurate and precise copying of DNA template by DNA polymerase. To access the information encoded in DNA,
Lynne S. Cox +2 more
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Stability Regulation of mRNA and the Control of Gene Expression
Annals of the New York Academy of Sciences, 2005Microarray technology has become highly valuable for identifying complex global changes in gene expression patterns. Standard techniques measure changes in total cellular poly(A) mRNA levels. The assumption that changes in gene expression as measured by these techniques are directly and well correlated with changes in rates of new gene synthesis form ...
Chris, Cheadle +7 more
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Stabilization of adhesion plaques by the expression of drebrin A in fibroblasts
Developmental Brain Research, 1996The expression of drebrin A was induced in mouse fibroblasts (L cells) after transformation of cells with a vector that carried cDNA for rat drebrin A (developmentally regulated brain protein A) under the control of the promoter of the gene for metallothionein-I.
K, Ikeda +5 more
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The role of mRNA and protein stability in gene expression
The FASEB Journal, 1989How important is the stability of gene products in the process of gene expression? We use a dual‐compartment mathematical model to demonstrate the effects that changing the rates of synthesis and degradation of hypothetical mRNAs and proteins would have on the final concentation of protein. The model predicts that the concentration
J L, Hargrove, F H, Schmidt
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Directed evolution of proteins for heterologous expression and stability
Current Opinion in Structural Biology, 2005Recent developments have been made in the application of directed evolution to achieve the efficient heterologous expression of proteins in Escherichia coli and yeast by increasing the stability and solubility of the protein in the host environment. One interesting conclusion that emerges is that the evolutionary process often improves the stability ...
Cintia, Roodveldt +2 more
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Stability and homogeneity of transgene expression in isogenic cells
Journal of Molecular Medicine, 2005Genetically engineered cells are an important tool not only for basic research applications, but also for biotechnology and molecular medicine. Among the issues yet to be solved for this technology are the consequences of randomly integrating DNA into a cell's genome.
Weimin, Liu +2 more
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Stabilization of cooperative virulence by the expression of an avirulent phenotype
Nature, 2013Pathogens often infect hosts through collective actions: they secrete growth-promoting compounds or virulence factors, or evoke host reactions that fuel the colonization of the host. Such behaviours are vulnerable to the rise of mutants that benefit from the collective action without contributing to it; how these behaviours can be evolutionarily stable
Diard, Médéric +6 more
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Expression and purification of active, stabilized trimethyllysine hydroxylase
Protein Expression and Purification, 2014Trimethyllysine hydroxylase (TMLH) catalyses the first step in carnitine biosynthesis - the conversion of N6,N6,N6-trimethyl-l-lysine to 3-hydroxy-N6,N6,N6-trimethyl-l-lysine. By changing carnitine availability it is possible to optimise cardiac energy metabolism, that is beneficial under certain ischemic conditions.
Andris, Kazaks +7 more
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Bacterial Expression and Stabilization of GPCRs
2014Although expression of G protein-coupled receptors in heterologous systems such as yeast, insect, and mammal cells has proven to be highly useful for structural studies, bacterial systems have still an interest, in particular for specific purposes such as isotopic labeling in nuclear magnetic resonance analyses. Different approaches have been developed
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Stabilization of Recombinantly Expressed Proteins
Annals of the New York Academy of Sciences, 1996F, Matthiesen, K R, Hejnaes, L, Skriver
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